Patent US5354336A successfully refreshed from Google Patents.
US5354336A
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US
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Method for bonding soft tissue with collagen-based adhesives and sealants
Assignee: CR Bard Inc
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Filing: 1993-03-15
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Granted: 1994-10-11
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Expires: 2013-03-15
Abstract
Abstract The present invention relates to a method for bonding soft tissues. The method comprises the steps of (a) applying a polymerizable collagen composition onto at least portion of a surface of at least one of a first tissue and a second tissue, (b) exposing the polymerizable collagen composition to an initiator so as to initiate polymerization of the polymerizable collagen composition and (c) contacting the first tissue and the second tissue so that the exposed polymerizable collagen composition forms a bond between the first tissue and the second tissue.
Inventors
- 👤 Charles D. Kelman
- 👤 Dale P. DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:24
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F9/00; A61F9/007; A61F9/0079; A61F9/008; A61F9/00802; A61F9/00817; A61F9/00819
Claims Analysis
Total Claims: 45
Claim 1
Independent Claim
79 words
A method for bonding soft tissues comprising the steps of: applying a polymerizable collagen composition onto at least a portion of a surface of at least one of a first tissue and a second tissue; exposing said polymerizable collagen composition to an initiator so as to initiate polymerization of said polymerizable collagen composition; and contacting said first tissue and said second tissue, wherein said exposed polymerizable collagen composition forms a bond between said first tissue and said second tissue.
Claim 2
Independent Claim
79 words
A method for bonding soft tissues comprising the steps of: applying a polymerizable collagen composition onto at least a portion of a surface of at least one of a first tissue and a second tissue; exposing said polymerizable collagen composition to an initiator so as to initiate polymerization of said polymerizable collagen composition; and contacting said first tissue and said second tissue, wherein said exposed polymerizable collagen composition forms a bond between said first tissue and said second tissue.
Claim 3
Dependent Claim
36 words
The method according to claim 1, wherein the collagen is at least one member selected from the group consisting of purified Type I collagen, purified Type III collagen, purified Type IV collagen and collagen rich tissue.
Claim 4
Dependent Claim
19 words
The method according to claim 2, wherein the Type I collagen is derived from human tissue or animal tissue.
Claim 5
Dependent Claim
15 words
The method according to claim 3, wherein the Type I collagen comprises autogenic human tissue,
Claim 6
Dependent Claim
60 words
The method according to claim 1, wherein the polymerizable collagen comprises a reaction product of collagen with at least acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, lauric anhydride, diglycolic anhydride, methyl succinic anhydride, methyl glutaric anhydride, dimethyl glutaric anhydride, exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride, 3,6-endoxo-3-methyl hexahydrophthalic anhydride, endo-3,6-dimethyl-3,6-endoxohexahydrophthalic anhydride, methacrylic anhydride, succinyl chloride, glutaryl chloride, and lauryl chloride.
Claim 7
Dependent Claim
13 words
The method according to claim 5, wherein the acylating agent is glutaric anhydride.
Claim 8
Dependent Claim
13 words
The method according to claim 5, wherein the acylating agent is methacrylic anhydride.
Claim 9
Dependent Claim
13 words
The method according to claim 5, wherein the acylating agent is exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride.
Claim 10
Dependent Claim
40 words
The method according to claim 1, wherein the polymerizable collagen comprises a reaction product of collagen with at least one sulfonating agent selected from the group consisting of anthraquinonone-1,5-disulfonic acid, 2-(chlorosulfonyl)-anthraquinone, 2-acrylamido-2-methyl-1-propane sulfonic acid, 8-hydroxyquinoline-5-sulfonic acid, and beta-styrene sulfonyl chloride.
Claim 11
Dependent Claim
15 words
The method according to claim 9, wherein the sulfonating agent is 2-(chlorosulfonyl)-anthraquinone or anthraquinone-1,5-disulfonic acid.
Claim 12
Dependent Claim
33 words
The method according to claim 1, wherein the initiator is a member selected from the group consisting of UV irradiation, sodium persulfate, sodium thiosulfate, ferrous chloride tetrahydrate, sodium bisulfite and an oxidative enzyme.
Claim 13
Dependent Claim
12 words
The method according to claim 11, wherein the initiator is UV irradiation.
Claim 14
Dependent Claim
12 words
The method according to claim 11, wherein the initiator is sodium persulfate.
Claim 15
Dependent Claim
15 words
The method according to claim 11, wherein the oxidative enzyme is peroxidase or catechol oxidase.
Claim 16
Independent Claim
65 words
A method for sealing lenticules onto a corneal surface comprising the steps of: placing said lenticule onto a corneal surface; applying a polymerizable collagen composition onto said lenticule and said corneal surface to form a collagen coating over said lenticule and said corneal surface; and exposing said coating to an initiator so as to polymerize said coating and seal said lenticule onto said corneal surface.
Claim 17
Independent Claim
65 words
A method for sealing lenticules onto a corneal surface comprising the steps of: placing said lenticule onto a corneal surface; applying a polymerizable collagen composition onto said lenticule and said corneal surface to form a collagen coating over said lenticule and said corneal surface; and exposing said coating to an initiator so as to polymerize said coating and seal said lenticule onto said corneal surface.
Claim 18
Dependent Claim
36 words
The method according to claim 15, wherein the collagen is at least one member selected from the group consisting of purified Type I collagen, purified Type III collagen, purified Type IV collagen and collagen rich tissue.
Claim 19
Dependent Claim
19 words
The method according to claim 16, wherein the Type I collagen is derived from human tissue or animal tissue.
Claim 20
Dependent Claim
15 words
The method according to claim 17, wherein the Type I collagen comprises autogenic human tissue.
Claim 21
Dependent Claim
59 words
The method according to claim 15, wherein the polymerizable collagen comprises a reaction product of collagen with at least one acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, lauric anhydride, diglycolic anhydride, methyl succinic anhydride, methyl glutaric anhydride, dimethyl glutaric anhydride, exo-3,6-epoxy-1,2,3,4-tetrahydrophthalicanhydride, 3,6-endoxo-3-methylhexahydrophthalic anhydride, endo-3,6-dimethyl-3,6-endoxohexahydrophthalic anhydride, methacrylic anhydride, succinyl chloride, glutaryl chloride, and lauryl chloride.
Claim 22
Dependent Claim
13 words
The method according to claim 19, wherein the acylating agent is glutaric anhydride.
Claim 23
Dependent Claim
13 words
The method according to claim 19, wherein the acylating agent is methacrylic anhydride.
Claim 24
Dependent Claim
13 words
The method according to claim 19, wherein the acylating agent is exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride.
Claim 25
Dependent Claim
40 words
The method according to claim 15, wherein the polymerizable collagen comprises a reaction product of collagen with at least one sulfonating agent selected from the group consisting of anthraquinonone-1,5-disulfonic acid, 2-(chlorosulfonyl)-anthraquinone, 2-acrylamido-2-methyl-1-propane sulfonic acid, 8-hydroxyquinoline-5-sulfonic acid, and beta-styrene sulfonyl chloride.
Claim 26
Dependent Claim
15 words
The method according to claim 23, wherein the sulfonating agent is 2-(chlorosulfonyl)-anthraquinone or anthraquinone-1,5-disulfonic acid.
Claim 27
Dependent Claim
32 words
The method according to claim 15, wherein the initiator is a member selected from the group consisting of irradiation, sodium persulfate, sodium thiosulfate, ferrous chloride tetrahydrate, sodium bisulfite and an oxidative enzyme.
Claim 28
Dependent Claim
12 words
The method according to claim 25, wherein the initiator is UV irradiation.
Claim 29
Dependent Claim
12 words
The method according to claim 25, wherein the initiator is sodium persulfate.
Claim 30
Dependent Claim
15 words
The method according to claim 25, wherein the oxidative enzyme is peroxidase or catechol oxidase.
Claim 31
Independent Claim
73 words
A method for sealing lenticules onto a corneal surface comprising the steps of: placing said lenticule onto a corneal surface; applying a polymerizable collagen composition around a periphery of said lenticule and an adjacent area of said cornea to form a collagen coating around said lenticule periphery and said adjacent corneal area; and exposing said coating to an initiator so as to polymerize said coating and seal said lenticule onto said corneal surface.
Claim 32
Independent Claim
73 words
A method for sealing lenticules onto a corneal surface comprising the steps of: placing said lenticule onto a corneal surface; applying a polymerizable collagen composition around a periphery of said lenticule and an adjacent area of said cornea to form a collagen coating around said lenticule periphery and said adjacent corneal area; and exposing said coating to an initiator so as to polymerize said coating and seal said lenticule onto said corneal surface.
Claim 33
Dependent Claim
36 words
The method according to claim 29, wherein the collagen is at least one member selected from the group consisting of purified Type I collagen, purified Type III collagen, purified Type IV collagen and collagen rich tissue.
Claim 34
Dependent Claim
19 words
The method according to claim 30, wherein the Type I collagen is derived from human tissue or animal tissue.
Claim 35
Dependent Claim
15 words
The method according to claim 31, wherein the Type I collagen comprises autogenic human tissue.
Claim 36
Dependent Claim
59 words
The method according to claim 29, wherein the polymerizable collagen comprises a reaction product of collagen with at least one acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, lauric anhydride, diglycolic anhydride, methyl succinic anhydride, methyl glutaric anhydride, dimethyl glutaric anhydride, exo-3,6-epoxy-1,2,3,4-tetrahydrophthalicanhydride, 3,6-endoxo-3-methylhexahydrophthalic anhydride, endo-3,6-dimethyl-3,6-endoxohexahydrophthalic anhydride, methacrylic anhydride, succinyl chloride, glutaryl chloride, and lauryl chloride.
Claim 37
Dependent Claim
13 words
The method according to claim 33, wherein the acylating agent is glutaric anhydride.
Claim 38
Dependent Claim
13 words
The method according to claim 33, wherein the acylating agent is methacrylic anhydride.
Claim 39
Dependent Claim
13 words
The method according to claim 33, wherein the acylating agent is exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride.
Claim 40
Dependent Claim
40 words
The method according to claim 29, wherein the polymerizable collagen comprises a reaction product of collagen with at least one sulfonating agent selected from the group consisting of anthraquinonone-1,5-disulfonic acid, 2-(chlorosulfonyl)anthraquinone, 2-acrylamido-2-methyl-1-propane sulfonic acid, 8-hydroxyquinoline-5-sulfonic acid, and beta-styrene sulfonyl chloride.
Claim 41
Dependent Claim
15 words
The method according to claim 37, wherein the sulfonating agent is 2-(chlorosulfonyl)-anthraquinone or anthraquinone-1,5-disulfonic acid.
Claim 42
Dependent Claim
33 words
The method according to claim 29, wherein the initiator is a member selected from the group consisting of I/V irradiation, sodium persulfate, sodium thiosulfate, ferrous chloride tetrahydrate, sodium bisulfite and an oxidative enzyme.
Claim 43
Dependent Claim
12 words
The method according to claim 39, wherein the initiator is UV irradiation.
Claim 44
Dependent Claim
12 words
The method according to claim 39, wherein the initiator is sodium persulfate.
Claim 45
Dependent Claim
15 words
The method according to claim 39, wherein the oxidative enzyme is peroxidase or catechol oxidase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-10 | 1998-04-11 | 1998-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-10 | 2002-04-11 | 2002-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-10 | 2006-04-11 | 2006-10-11 | $7700.00 | Window Closed / Lapsed |