US5342646A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for making carrier systems for biologically active materials
Assignee: Huels AG
•
Filing: 1992-11-19
•
Granted: 1994-08-30
•
Expires: 2012-11-19
Abstract
Abstract What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.
Inventors
- 👤 Wolfgang Kleese
- 👤 Dieter Kraemer
- 👤 Hans-Ulrich Petereit
- 👤 Klaus Lehmann
- 👤 Werner Siol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 06:11
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/545; C; C07; C07K; C07K17/00; C07K17/02; C07K17/08; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
62 words
A method for making a carrier for the covalent bonding thereto of a biologically active material, which method comprises coating a solid support with a dispersion of a film-forming polymer and with another dispersion of a non-film-forming polymer, at least one of the polymers including a monomer having at least one functional group capable of covalently bonding with the biologically active material.
Claim 2
Independent Claim
62 words
A method for making a carrier for the covalent bonding thereto of a biologically active material, which method comprises coating a solid support with a dispersion of a film-forming polymer and with another dispersion of a non-film-forming polymer, at least one of the polymers including a monomer having at least one functional group capable of covalently bonding with the biologically active material.
Claim 3
Dependent Claim
17 words
A method as in claim 1 wherein the support is coated with a mixture of the dispersions.
Claim 4
Dependent Claim
11 words
A method as in claim 1 wherein the support is inorganic.
Claim 5
Dependent Claim
11 words
A method as in claim 1 wherein the support is organic.
Claim 6
Dependent Claim
16 words
A method as in claim 1 wherein the support is in the form of spherical particles.
Claim 7
Dependent Claim
19 words
A method as in claim 5 wherein the spherical particles have an average diameter from 0.01 to 10 millimeters.
Claim 8
Dependent Claim
31 words
A method as in claim 1 wherein the polymers each comprise at least one monomer selection from the group consisting of acrylates, methacrylates, styrene, alkyl styrenes, vinyl esters, and vinyl halides.
Claim 9
Dependent Claim
74 words
A method as in claim 1 where the polymer in at least one of the dispersions comprises at least one monomer of the formula Z-(R) n -X , wherein X is a functional group selected from the group consisting of sulfonic acid halide, thioisocyanate, thiocarbonyldioxy, carbonyl-imidoyldioxy, haloethoxy, aziridine, epoxy, formyl, keto, acryloyl, anhydride, and active ester groups, R is a chemically inert spacer, n is 0 or 1, and Z is a polymerizable entity.
Claim 10
Dependent Claim
41 words
A method as in claim 1 wherein the polymers each comprise at least one monomer, different from the monomer having at least one functional group, selected from the group consisting of acrylates, methacrylates, styrene, alkyl styrenes, vinyl esters, and vinyl halides.
Claim 11
Dependent Claim
74 words
A method as in claim 9 where the polymer in at least one of the dispersions comprises at least one monomer of the formula Z-(R) n -X , wherein X is a functional group selected from the group consisting of sulfonic acid halide, thioisocyanate, thiocarbonyldioxy, carbonyl-imidoyldioxy, haloethoxy, aziridine, epoxy, formyl, keto, acryloyl, anhydride, and active ester groups, R is a chemically inert spacer, n is 0 or 1, and Z is a polymerizable entity.
Claim 12
Dependent Claim
21 words
A method as in claim 1 wherein the monomer having at least one functional group is present in the non-film-forming polymer.
Claim 13
Dependent Claim
36 words
A method as in claim 1 wherein the monomer having at least one functional group is present in an amount from 0.1 to 80 percent by weight of the film-forming polymer or of the non-film-forming polymer.
Claim 14
Dependent Claim
69 words
A method as in claim 1 wherein the polymers each further comprise at least 50 percent by weight of monomers of the formula ##STR8## wherein R 1 is hydrogen, methyl, or --CH 2 --COOR 2 , R 2 is alkyl having 1 to 4 carbon atoms, and R 3 is linear or branched alkyl having 1 to 18 carbon atoms or is cycloalkyl having 3 to 12 ring members.
Claim 15
Dependent Claim
19 words
A method as in claim 11 wherein the film-forming polymer has a minimum film forming temperature below 60° C.
Claim 16
Dependent Claim
19 words
A method as in claim 14 wherein the non-film-forming polymer has a freezing point of at least 30° C.
Claim 17
Dependent Claim
28 words
A method as in claim 1 wherein the film-forming polymer is present in the film-forming dispersion as particles having an average particle size from 0.02 to 5 microns.
Claim 18
Dependent Claim
29 words
A method as in claim 1 wherein the non-film-forming polymer is present in the non-film-forming polymer dispersion as particles having an average particle size from 0.04 to 5 microns.
Claim 19
Dependent Claim
50 words
A method as in claim 11 wherein the polymers in the film-forming and non-film-forming dispersions are present as particles and the average size of the particles in the non-film-forming dispersion is larger than the average size of the particles in the film-forming dispersion by a factor of 1.2 to 20.
Claim 20
Dependent Claim
32 words
A method as in claim 11 wherein the ratio by dry weight of polymer in the non-film-forming dispersion to dry weight of polymer in the film-forming dispersion is from 50:50 to 99:1.
Claim 21
Dependent Claim
15 words
A method as in claim 1 wherein the support is coated by immersion or spraying.
Claim 22
Dependent Claim
15 words
A method as in claim 2 wherein the support is coated by immersion or spraying.
References Cited (Backward Citations)
DE2016729A1
Cited
GB1276006A
Cited
GB1274869A
Cited
US4357363A
Cited
US4357142A
Cited
US4710525A
Cited
CA1212058A
Cited
EP0071704A2
Cited
US5217492A
Cited
US4824640A
Cited
US4945146A
Cited
US4921915A
Cited
US5248709A
Cited
US5219527A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-29 | 1998-02-28 | 1998-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-29 | 2002-02-28 | 2002-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-29 | 2006-02-28 | 2006-08-30 | $7700.00 | Window Closed / Lapsed |