Patent US3390577A successfully refreshed from Google Patents.
Patent US5334381A successfully refreshed from Google Patents.
US5334381A
Expired / Lapsed
US
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Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
Assignee: Bristol Myers Squibb Pharma Co
•
Filing: 1993-06-30
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Granted: 1994-08-02
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Expires: 2013-06-30
Abstract
Abstract Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:33
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/227; A61K41/00; A61K41/0028; A61K41/0052; A61K49/06; A61K49/18; A61K49/1806; A61K49/1815; A61K49/223; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; A61K9/1278; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
23 words
A method for synthesizing a liposome having encapsulated therein a gas comprising contacting liposomes in an aqueous medium with gas under elevated pressures.
Claim 2
Independent Claim
23 words
A method for synthesizing a liposome having encapsulated therein a gas comprising contacting liposomes in an aqueous medium with gas under elevated pressures.
Claim 3
Dependent Claim
17 words
A method according to claim 1 wherein said pressure is between about 50 and about 120 psi.
Claim 4
Dependent Claim
16 words
A method according to claim 1 further comprising contacting said liposomes with gas under decreased temperature.
Claim 5
Dependent Claim
18 words
A method according to claim 3 wherein said decreased temperature is between about 1° and about 4° C.
Claim 6
Dependent Claim
25 words
A method according to claim 1 wherein said gas is selected from the group consisting of nitrogen, oxygen, carbon dioxide, xenon, argon, neon and helium.
Claim 7
Dependent Claim
12 words
A method according to claim 1 wherein said liposomes comprise egg phosphatidylcholine.
Claim 8
Dependent Claim
11 words
A method according to claim 5 wherein said gas is nitrogen.
Claim 9
Dependent Claim
11 words
A method according to claim 5 wherein said gas is oxygen.
Claim 10
Dependent Claim
12 words
A method according to claim 5 wherein said gas is carbon dioxide.
Claim 11
Dependent Claim
11 words
A method according to claim 5 wherein said gas is xenon.
Claim 12
Dependent Claim
11 words
A method according to claim 5 wherein said gas is argon.
Claim 13
Dependent Claim
11 words
A method according to claim 5 wherein said gas is neon.
Claim 14
Dependent Claim
11 words
A method according to claim 5 wherein said gas is helium.
Claim 15
Dependent Claim
50 words
A method according to claim 1 wherein said method further comprises contacting said liposomes with gas under decreased temperature, wherein said pressure is between about 50 and about 120 psi, and wherein said gas is selected from the group consisting of nitrogen, oxygen, carbon dioxide, xenon, argon, neon and helium.
Claim 16
Dependent Claim
18 words
The method according to claim 14 wherein said decreased temperature is between about 1° and about 4° C.
Claim 17
Dependent Claim
11 words
A method according to claim 15 wherein said gas is nitrogen.
Claim 18
Dependent Claim
11 words
A method according to claim 15 wherein said gas is oxygen.
Claim 19
Dependent Claim
12 words
A method according to claim 15 wherein said gas is carbon dioxide
Claim 20
Dependent Claim
11 words
A method according to claim 15 wherein said gas is xenon.
Claim 21
Dependent Claim
11 words
A method according to claim 15 wherein said gas is argon.
Claim 22
Dependent Claim
11 words
A method according to claim 15 wherein said gas is neon.
Claim 23
Dependent Claim
11 words
A method according to claim 15 wherein said gas is helium.
Claim 24
Dependent Claim
12 words
A method according to claim 15 wherein said liposomes comprise egg phosphatidylcholine.
Claim 25
Dependent Claim
11 words
A method according to claim 23 wherein said gas is nitrogen.
Claim 26
Dependent Claim
11 words
A method according to claim 23 wherein said gas is oxygen.
Claim 27
Dependent Claim
12 words
A method according to claim 23 wherein said gas is carbon dioxide.
Claim 28
Dependent Claim
11 words
A method according to claim 23 wherein said gas is xenon.
Claim 29
Dependent Claim
11 words
A method according to claim 23 wherein said gas is argon.
Claim 30
Dependent Claim
11 words
A method according to claim 23 wherein said gas is neon.
Claim 31
Dependent Claim
11 words
A method according to claim 23 wherein said gas is helium.
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