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US4603044A Expired / Lapsed US ⏱️ 0.0 years remaining

Hepatocyte Directed Vesicle delivery system

Assignee: TECHNOLOGY UNLIMITED A OF OHIO LP
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Filing: 1984-05-03
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Granted: 1986-07-29
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Expires: 2004-05-03
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Abstract

Abstract A targeted drug delivery system which has specificity for hepatobiliary receptors, which are the specialized metabolic cells of the liver. Hereinafter, this will be referred to as a Hepatocyte Directed Vesicle, or abbreviated as HDV. This preferred directed delivery system utilizes a bipolar lipid for the majority of its vesicle membrane structure. The targeting material, which is only a minor constituent of a targeted vesicle system, has a specificity for hepatobiliary receptors of the liver. The Hepatocyte Directed Vesicle is then attracted to the receptor, and the vesicle releases its pharmacological cargo. This disclosure specifies that the attachment of the targeting material, or molecule, to the vesicle is preferably done by first providing a connector molecule, having a portion inserted into the wall of the vesicle, by reason of being lipophilic, and a portion which is hydrophilic and is projected from the vesicle wall. The target, by connector molecules, are tied together to extend or project the target molecule a distance from the vescile wall. Any chemical molecule capable of circulating in the bloodstream of a warm-blooded animal and attracted to the hepatobiliary receptors will serve as a target substance for this invention. This invention is in the discovery of a unique and unprecedented result of directing a vesicle containing a pharmacological load to the hepatobiliary receptors.

Inventors

  • 👤 W. Blair Geho
  • 👤 John R. Lau

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:28
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/14; A61K47/00; A61K47/50; A61K47/69; A61K47/6905; A61K47/6911; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61Q; A61Q11/00; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 87 words
A composition of matter for internal administration in the therapeutic treatment of a warm-blooded animal comprising: a first component which is a drug or diagnostic agent, said first component being encapsulated in or associated with; a second component which comprises lipid membrane structures in the form of vesicles or liposomes; and a third component which is a molecule having a fatty substituent attached to the vesicle wall and a target substituent selected from the class consisting of those chemicals which are classed biologically as biliary attracted chemicals.
Claim 2
Dependent Claim 87 words
A composition of matter for internal administration in the therapeutic treatment of a warm-blooded animal comprising: a first component which is a drug or diagnostic agent, said first component being encapsulated in or associated with; a second component which comprises lipid membrane structures in the form of vesicles or liposomes; and a third component which is a molecule having a fatty substituent attached to the vesicle wall and a target substituent selected from the class consisting of those chemicals which are classed biologically as biliary attracted chemicals.
Claim 3
Dependent Claim 20 words
A composition of matter as defined in claim 1 wherein the third component target substituent is a substituted iminodiacetate complex.
Claim 4
Dependent Claim 23 words
A composition of matter as defined in claim 1 wherein the third component is two substantially identical substituents joined by a bridge molecule.
Claim 5
Dependent Claim 24 words
A composition of matter as defined in claim 1 wherein the third component is two substituted iminodiacetate complex molecules joined by a bridge molecule.
Claim 6
Independent Claim 43 words
The method of preparing a composition of matter for delivering a dose of hepatic therapeutic chemical, comprising incorporating said chemical with a lipid vesicle and connecting a chemical target molecule to the vesicle, said target molecule having preferential affinity for the hepatobiliary receptors.
Claim 7
Independent Claim 43 words
The method of preparing a composition of matter for delivering a dose of hepatic therapeutic chemical, comprising incorporating said chemical with a lipid vesicle and connecting a chemical target molecule to the vesicle, said target molecule having preferential affinity for the hepatobiliary receptors.
Claim 8
Dependent Claim 84 words
A composition of matter for internal administration in the delivery of an effective dose of a chemical to the liver of a warm-blooded animal, comprising: a lipid vesicle defined by bipolar wall and containing a pharmacological cargo intended for internal utilization by the liver; and a compound consisting of a lipophilic substituent held in the wall of the vesicle and joined by a connector molecule to a target substituent selected from the class consisting of those chemicals which are classed biologically as biliary attracted.
Claim 9
Dependent Claim 84 words
A composition of matter for internal administration in the delivery of an effective dose of a chemical to the liver of a warm-blooded animal, comprising: a lipid vesicle defined by bipolar wall and containing a pharmacological cargo intended for internal utilization by the liver; and a compound consisting of a lipophilic substituent held in the wall of the vesicle and joined by a connector molecule to a target substituent selected from the class consisting of those chemicals which are classed biologically as biliary attracted.
Claim 10
Dependent Claim 76 words
A composition of matter for therapeutic treatment of a warm-blooded animal, comprising: a composite structure of a lipid vesicle, and a target moiety; said target moiety having a physical structure of a fatty substituent attached to the vesicle wall and a target substituent oriented in three-dimensional space extended away from the membrane surface; said target substituent selected from the class consisting of those chemicals which are classed biologically as having a high affirmity for hepatobiliary receptors.
Claim 11
Dependent Claim 76 words
A composition of matter for therapeutic treatment of a warm-blooded animal, comprising: a composite structure of a lipid vesicle, and a target moiety; said target moiety having a physical structure of a fatty substituent attached to the vesicle wall and a target substituent oriented in three-dimensional space extended away from the membrane surface; said target substituent selected from the class consisting of those chemicals which are classed biologically as having a high affirmity for hepatobiliary receptors.

References Cited (Backward Citations)

US4091088A Cited
GB1545427A Cited
US4377567A Cited
US4318898A Cited
US4310505A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-07-28 1990-01-27 1990-07-29 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-07-28 1994-01-27 1994-07-29 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-07-28 1998-01-27 1998-07-29 $7700.00 Window Closed / Lapsed

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