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Patent US5331027A successfully refreshed from Google Patents.
US5331027A
Expired / Lapsed
US
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Lubricious hydrophilic coating, resistant to wet abrasion
Assignee: Angiotech Biocoatings Corp
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Filing: 1993-05-25
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Granted: 1994-07-19
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Expires: 2013-05-25
Abstract
Abstract The lubricious hydrophilic coatings of the invention are significantly more lubricious when wet than when dry, are adherent to a variety of substrates, and are resistant to removal by wet abrasion. In one embodiment, the coatings include a hydrophilic polyolefin such as polyvinyl-pyrrolidone and a water-insoluble stabilizing polymer such as a cellulose ester. The coatings may also include an adherent polymer and a plasticizing agent. The coating may be applied by preparing a solution of the stabilizing polymer and a solution of the hydrophilic polyolefin, and coating the substrate first in one then the other. Alternatively, both the stabilizing and hydrophilic polymers may be dissolved in a single solvent system and applied to the substrate in a single step. In another embodiment, only a solution of a hydrophilic polyolefin is applied directly to the substrate. In this embodiment, the solution of the hydrophilic polyolefin includes a cosolvent which acts as a solvent for both the hydrophilic polyolefin and the substrate. The coatings of the invention may be applied to biomedical devices and implants such as catheters, condoms, and nasogastric and endotracheal tubes.
Inventors
- 👤 Richard J. Whitbourne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:29
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L31/00; A61L31/08; A61L31/10; A61L31/14; C; C08; C08J; C08J2339/00; C08J2339/04; C08J2339/06; C08J2401/00; C08J2401/02; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31507; Y10T428/3154; Y10T428/31551; Y10T428/31554; Y10T428/31562; Y10T428/31565; Y10T428/31573; Y10T428/31576; Y10T428/3158; Y10T428/31587; Y10T428/31598; Y10T428/31601; Y10T428/31605; Y10T428/31616; Y10T428/31623; Y10T428/31645; Y10T428/31649; Y10T428/31652; Y10T428/31667; Y10T428/31678; Y10T428/31681; Y10T428/31692; Y10T428/31699; Y10T428/31725; Y10T428/31728; Y10T428/31732; Y10T428/31739; Y10T428/31743; Y10T428/31746; Y10T428/3175; Y10T428/31757; Y10T428/31786; Y10T428/31797; Y10T428/31855; Y10T428/31909; Y10T428/31913; Y10T428/31917
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
68 words
A lubricious hydrophilic coating for an organic polymeric surface which is substantially more slippery when wet than when dry, and resistant to removal by wet abrasion comprising a single layer of a hydrophilic polymer selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, nylon, and a mixture thereof.
Claim 2
Dependent Claim
68 words
A lubricious hydrophilic coating for an organic polymeric surface which is substantially more slippery when wet than when dry, and resistant to removal by wet abrasion comprising a single layer of a hydrophilic polymer selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, nylon, and a mixture thereof.
Claim 3
Dependent Claim
41 words
The coating of claim 1 which is adapted to be applied to a polymer surface comprising a polymer selected from the group consisting of polyurethane, polyvinylchloride, polyacrylate, polycarbonate, polystyrene, polyester resins, polybutadiene-styrene copolymers, nylon, polypropylene, polybutylene, teflon, silicon, and polyvinyl acetal.
Claim 4
Dependent Claim
32 words
The coating of claim 1, wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone and polyvinylpyrrolidone-vinyl acetate, said stabilizing polymer is nitrocellulose, and said organic polymeric surface is polyurethane.
Claim 5
Dependent Claim
121 words
A lubricious hydrophilic coating for an organic polymeric surface which is substantially more slippery when wet than when dry, and resistant to removal by wet abrasion comprising a single layer of a hydrophilic polymer selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, said hydrophilic polymer coating having an exposed outer surface and an interfacing surface with said polymer surface, said hydrophilic coating having a high degree of cross-linking or intermolecular mingling between said hydrophilic polymer and said polymer surface at said interfacing surface relative to said outer surface.
Claim 6
Dependent Claim
121 words
A lubricious hydrophilic coating for an organic polymeric surface which is substantially more slippery when wet than when dry, and resistant to removal by wet abrasion comprising a single layer of a hydrophilic polymer selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, said hydrophilic polymer coating having an exposed outer surface and an interfacing surface with said polymer surface, said hydrophilic coating having a high degree of cross-linking or intermolecular mingling between said hydrophilic polymer and said polymer surface at said interfacing surface relative to said outer surface.
Claim 7
Dependent Claim
41 words
The coating of claim 4, which is adapted to be applied to a polymer surface comprising a polymer selected from the group consisting of polyurethane, polyvinylchloride, polyacrylate, polycarbonate, polystyrene, polyester resins, polybutadiene-styrene copolymers, nylon, polypropylene, polybutylene, teflon, silicon, and polyvinyl acetal.
Claim 8
Dependent Claim
35 words
The coating of claim 5, wherein the degree of lubricity and resistance to wet abrasion is controlled in part by the degree of cross-linking or intermolecular mingling between said hydrophilic polymer and said polymer surface.
Claim 9
Dependent Claim
123 words
A lubricious hydrophilic coating for an organic polymer surface, comprising a single layer of a hydrophilic polymer having an exposed outer surface and an interfacing surface and being selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, and a cosolvent for both said hydrophilic polymer and said polymer surface, said hydrophilic polymer having a high degree of cross-linking or intermolecular mingling with said polymer surface interfacing said polymer surface relative to said outer surface, said coating being substantially more slippery when wet than when dry and resistant to removal by wet abrasion.
Claim 10
Dependent Claim
123 words
A lubricious hydrophilic coating for an organic polymer surface, comprising a single layer of a hydrophilic polymer having an exposed outer surface and an interfacing surface and being selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone polyvinyl acetate copolymer, and a mixture thereof, a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, and a cosolvent for both said hydrophilic polymer and said polymer surface, said hydrophilic polymer having a high degree of cross-linking or intermolecular mingling with said polymer surface interfacing said polymer surface relative to said outer surface, said coating being substantially more slippery when wet than when dry and resistant to removal by wet abrasion.
Claim 11
Dependent Claim
159 words
A lubricious hydrophilic coating, comprising a single layer of a lubricious hydrophilic polymer comprising polyvinylpyrrolidone, capable of penetrating a polymer surface of a substrate comprising polyurethane or polyvinyl chloride via use of a cosolvent for both polyvinylpyrrolidone and polyurethane or polyvinyl chloride, said hydrophilic polymer having an exposed outer surface and an interfacing surface with said polymer surface, said hydrophilic coating having a high degree of cross-linking or intermolecular mingling between the polyvinylpyrrolidone and polyurethane or polyvinyl chloride at said interfacing surface relative to said outer surface, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, said hydrophilic coating being substantially more slippery when wet than when dry, and resistant to removal by wet abrasion, the degree of lubricity and resistance to wet removal being controlled in part by the particular cosolvent used and the amount and type of stabilizing polymer used.
Claim 12
Dependent Claim
159 words
A lubricious hydrophilic coating, comprising a single layer of a lubricious hydrophilic polymer comprising polyvinylpyrrolidone, capable of penetrating a polymer surface of a substrate comprising polyurethane or polyvinyl chloride via use of a cosolvent for both polyvinylpyrrolidone and polyurethane or polyvinyl chloride, said hydrophilic polymer having an exposed outer surface and an interfacing surface with said polymer surface, said hydrophilic coating having a high degree of cross-linking or intermolecular mingling between the polyvinylpyrrolidone and polyurethane or polyvinyl chloride at said interfacing surface relative to said outer surface, and a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, cellulose acetate butyrate, cellulose acetate propionate, cellulose nitrate, ethyl cellulose, and hydroxyethylcellulose, said hydrophilic coating being substantially more slippery when wet than when dry, and resistant to removal by wet abrasion, the degree of lubricity and resistance to wet removal being controlled in part by the particular cosolvent used and the amount and type of stabilizing polymer used.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-07-18 | 1998-01-17 | 1998-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-07-18 | 2002-01-17 | 2002-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-07-18 | 2006-01-17 | 2006-07-19 | $7700.00 | Window Closed / Lapsed |