US5001009A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lubricious hydrophilic composite coated on substrates
Assignee: Angiotech Biocoatings Corp
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Filing: 1987-09-02
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Granted: 1991-03-19
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Expires: 2007-09-02
Abstract
Abstract The lubricious hydrophilic coatings of the invention include a hydrophilic polyolefin such as polyvinyl-pyrrolidone and a water-insoluble stabilizing polymer such as a cellulose ester. The coatings may also include an adherent polymer and a plasticizing agent. The coatings are significantly more lubricious when wet than when dry, are adherent to a variety of substrates, and are resistant to removal by wet abrasion. The coating method of the invention involves preparing a solution of the stabilizing polymer and a solution of the hydrophilic polyolefin, and coating the substrate first in one then the other. Alternatively, both the insolubilizing and hydrophilic polymers may be dissolved in a single solvent system and applied to the substrate in a single step. The solutions of the invention are stable, non-reactive, and non-hazardous. The coatings of the invention may be applied to biomedical devices and implants such as catheters, condoms, and nasogastric and endotracheal tubes.
Inventors
- 👤 Richard J. Whitbourne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:57
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L31/00; A61L31/08; A61L31/10; A61L31/14; C; C08; C08J; C08J2339/00; C08J2339/04; C08J2339/06; C08J2401/00; C08J2401/02; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31507; Y10T428/3154; Y10T428/31551; Y10T428/31554; Y10T428/31562; Y10T428/31565; Y10T428/31573; Y10T428/31576; Y10T428/3158; Y10T428/31587; Y10T428/31598; Y10T428/31601; Y10T428/31605; Y10T428/31616; Y10T428/31623; Y10T428/31645; Y10T428/31649; Y10T428/31652; Y10T428/31667; Y10T428/31678; Y10T428/31681; Y10T428/31692; Y10T428/31699; Y10T428/31725; Y10T428/31728; Y10T428/31732; Y10T428/31739; Y10T428/31743; Y10T428/31746; Y10T428/3175; Y10T428/31757; Y10T428/31786; Y10T428/31797; Y10T428/31855; Y10T428/31909; Y10T428/31913; Y10T428/31917
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
117 words
A lubricious composite, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer, a mixture of the above, and the like, an inner layer comprising a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, a copolymer of polymethyl vinyl ether and maleic anhydride, an ester of the copolymer, and nylon, said composite being substantially more slippery when wet than when dry, resistant to removal by wet abrasion, and essentially insoluble in aqueous solution, the ratio of said hydrophilic polymer to said stabilizing polymer altering the degree of wet lubricity, resistance to removal, and insolubility of said composite.
Claim 2
Dependent Claim
117 words
A lubricious composite, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer, a mixture of the above, and the like, an inner layer comprising a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, a copolymer of polymethyl vinyl ether and maleic anhydride, an ester of the copolymer, and nylon, said composite being substantially more slippery when wet than when dry, resistant to removal by wet abrasion, and essentially insoluble in aqueous solution, the ratio of said hydrophilic polymer to said stabilizing polymer altering the degree of wet lubricity, resistance to removal, and insolubility of said composite.
Claim 3
Dependent Claim
13 words
The coating of claim 1, wherein said inner layer includes a hydrophilic polymer.
Claim 4
Dependent Claim
13 words
The coating of claim 1, wherein said outer layer includes a stabilizing polymer.
Claim 5
Dependent Claim
12 words
The coating of claim 1 which is applied to a metallic substrate.
Claim 6
Dependent Claim
10 words
The coating of claim 1 which is applied to glass.
Claim 7
Dependent Claim
35 words
The coating of claim 1 which is applied to a polymeric substrate selected from the group consisting of polyurethane, polyvinylchloride, polyacrylate, polycarbonate, polystryrene, polyester resins, polybutadiene-styrene copolymers, nylon, polypropylene, polybutylene, teflon, silicon, and polyvinyl acetal.
Claim 8
Dependent Claim
129 words
An article having a lubricious composite coating, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer; a mixture of the above, and the like, an inner layer comprising a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, a copolymer of polymethyl vinyl ether and maleic anhydride, an ester of the copolymer, and nylon, a substrate to which said inner layer adheres, said composite being substantially more slippery when wet than when dry, resistant to removal by wet abrasion, and essentially insoluble in aqueous solution, the ratio of said hydrophilic polymer to said stabilizing polymer altering the degree of wet lubricity, resistance to removal, and insolubility of said composite.
Claim 9
Dependent Claim
129 words
An article having a lubricious composite coating, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer; a mixture of the above, and the like, an inner layer comprising a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, a copolymer of polymethyl vinyl ether and maleic anhydride, an ester of the copolymer, and nylon, a substrate to which said inner layer adheres, said composite being substantially more slippery when wet than when dry, resistant to removal by wet abrasion, and essentially insoluble in aqueous solution, the ratio of said hydrophilic polymer to said stabilizing polymer altering the degree of wet lubricity, resistance to removal, and insolubility of said composite.
Claim 10
Dependent Claim
46 words
The article of claim 7, wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone and polyvinylpyrrolidone-vinyl acetate, and said stabilizing polymer is selected from the group consisting of cellulose acetate, cellulose acetate butyrate, cellulose acetate proprionate, cellulose nitrate, ethyl cellulose, and hydroxyethyl cellulose.
Claim 11
Dependent Claim
13 words
The article of claim 8, wherein said inner layer includes a plasticizing agent.
Claim 12
Dependent Claim
23 words
The article of claim 8, wherein said inner layer includes an adherent polymer for promoting bonding between said substrate and said inner layer.
Claim 13
Dependent Claim
10 words
The article of claim 7, wherein said substrate is metal.
Claim 14
Dependent Claim
10 words
The article of claim 7, wherein said substrate is glass.
Claim 15
Dependent Claim
32 words
The article of claim 7, wherein said substrate is selected from the group consisting of polyurethane, polyvinylchloride, polyacrylate, polycarbonate, polystryrene, polyester resins, polybutadiene-styrene copolymers, nylon, polypropylene, polybutylene, teflon, silicon, and polyvinyl acetal.
Claim 16
Dependent Claim
32 words
The coating of claim 1 in which the stabilizing polymer is selected from the group consisting of cellulose acetate, cellulose acetate butyrate, cellulose acetate proprionate, cellulose nitrate, ethyl cellulose, and hydroxyethyl cellulose.
Claim 17
Dependent Claim
11 words
The coating of claim 1 which further comprising an adherent polymer.
Claim 18
Dependent Claim
27 words
The coating of claim 1, further comprising an adherent polymer selected from the group consisting of polyester, polyurethane, styrene polybutadiene, acrylic resin, polyvinylidene chloride, polycarbonate, and polyvinylchloride,
Claim 19
Dependent Claim
10 words
The coating of claim 1, further comprising a plasticizing agent.
Claim 20
Dependent Claim
34 words
The coating of claim 1, further comprising a plasticizing agent selected from the group consisting of camphor, polyvinyl butyral, dibutylphthalate, castor oil, dioctyl phthalate, acetyl tributyl citrate, dibutyl sebacate, sebacic acid, and alkyl resin.
References Cited (Backward Citations)
US3914341A
Cited
US3975350A
Cited
US4038264A
Cited
US3939049A
Cited
US4156067A
Cited
US4156066A
Cited
US4255550A
Cited
US4496535A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-03-18 | 1994-09-17 | 1995-03-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-18 | 1998-09-17 | 1999-03-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-18 | 2002-09-17 | 2003-03-19 | $7700.00 | Window Closed / Lapsed |