US5304334A — Method of preparing a multiphase composition

Claim 1

Independent Claim 125 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier, a silicone-based emulsifier and an oleophobic, hydrophobic silicone fluid in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion a thermotropic liquid crystal and a perfluoropolyether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Claim 2

Independent Claim 125 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier, a silicone-based emulsifier and an oleophobic, hydrophobic silicone fluid in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion a thermotropic liquid crystal and a perfluoropolyether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Claim 3

Dependent Claim 18 words

The method of claim 1 in which each of the process steps is carried out under homogenizing conditions.

Claim 4

Independent Claim 99 words

A method of stabilizing a multiphase composition in which independent phases of water, a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing water-soluble polymer, a liquid crystal and a perfluoropolyether are dispersed in a continuous phase of silicone fluid comprising adding an effective amount of a water-soluble polymeric emulsifier, or an aqueous solution thereof, to an aqueous mixture of an oleophobic, hydrophobic silicone fluid and a silicone-based emulsifier to form a stable water-in-oil emulsion and adding to said emulsion gel, said liquid crystal and perfluoropolyether components of said multiphase composition.

Claim 5

Independent Claim 99 words

A method of stabilizing a multiphase composition in which independent phases of water, a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing water-soluble polymer, a liquid crystal and a perfluoropolyether are dispersed in a continuous phase of silicone fluid comprising adding an effective amount of a water-soluble polymeric emulsifier, or an aqueous solution thereof, to an aqueous mixture of an oleophobic, hydrophobic silicone fluid and a silicone-based emulsifier to form a stable water-in-oil emulsion and adding to said emulsion gel, said liquid crystal and perfluoropolyether components of said multiphase composition.

Claim 6

Dependent Claim 35 words

The method of claim 1 or 3 in which said multiphase composition is further characterized as being capable of undergoing a temporary phase inversion upon exposure to external pressure, shear or other form of stress.

Claim 7

Dependent Claim 28 words

The method of claim 1 or 3 in which said multiphase composition is further characterized as being capable of providing high initial moisturization followed by lower sustained moisturization.

Claim 8

Dependent Claim 17 words

The method of claim 1 or 2 in which said gel further includes releasable bioavailable water-soluble ingredients.

Claim 9

Dependent Claim 26 words

The method of claim 1 or 3 in which an oil capable of carrying and releasing lipid-soluble ingredients is used in place of said liquid crystal.

Claim 10

Dependent Claim 14 words

The method of claim 7 in which said oil is non-surface active and non-detergent.

Claim 11

Dependent Claim 25 words

The method of claim 7 in which said oil comprises a material selected from the group consisting of long-chain saturated fats, waxes and cholesteric molecules.

Claim 12

Dependent Claim 28 words

The method of claim 1 or 3 which further comprises dispersing in said multiphase composition a preselected amount of an oil capable of carrying and releasing lipid-soluble ingredients.

Claim 13

Dependent Claim 18 words

The liquid crystal phase according to claims 1 or 3 in which said liquid crystal comprises cholesteric esters.

Claim 14

Dependent Claim 69 words

The method of claim 1 or 3 in which said water-soluble polymeric emulsifier is a material selected from the group consisting of HYPAN SS-201, CARBOPOL 940, STABILEZE 06 and a copolymer of C 10-30 alkyl acrylates and at least one monomer of a material selected from the group consisting of acrylic acid, methacrylic acid and one of their simple esters, crosslinked with an alkyl ether of sucrose or pentaerythritol.

Claim 15

Dependent Claim 35 words

The method of claim 1 or 3 in which said water-soluble polymeric emulsifier is a carbomer, a polyacrylic acid, a polyacrylamide, an alginated-based polymer, a cellulosic thickener, a locust bean polymer, polyglycerylmethylacrylate or mixtures thereof.

Claim 16

Dependent Claim 16 words

The method of claim 1 or 3 in which said oleophobic, hydrophobic silicone fluid comprises dimethicone.

Claim 17

Dependent Claim 15 words

The method of claim 1 or 3 in which said silicone-based emulsifier comprises dimethicone copolyol.

Claim 18

Dependent Claim 15 words

The method of claim 1 or 3 in which said perfluoropolyether comprises a perfluoropolyalkyl ether.

Claim 19

Dependent Claim 14 words

The method of claim 1 or 3 in which said gel is acid neutralized.

Claim 20

Dependent Claim 14 words

The method of claim 17 in which said neutralization is effected with a base.

Claim 21

Dependent Claim 24 words

The method of claim 18 in which said base is an amine selected from the group consisting of triethanolamine, tris(hydroxymethyl)aminoethane, ethylenediamine and mixtures thereof.

Claim 22

Dependent Claim 30 words

The method of claim 1 or 3 in which said polydisperse water phase exists as droplets having a diameter falling in the range of about 0.01 to about 3000 microns.

Claim 23

Dependent Claim 30 words

The method of claim 1 or 3 in which said polydisperse water phase exists as droplets having a diameter falling in the range of about 0.1 to about 500 microns.

Claim 24

Dependent Claim 30 words

The method of claim 1 or 3 in which said polydisperse gel phase exists as droplets having a diameter falling in the range of about 0.01 to about 3000 microns.

Claim 25

Dependent Claim 30 words

The method of claim 1 or 3 in which said polydisperse gel phase exists as droplets having a diameter falling in the range of about 0.1 to about 500 microns.

Claim 26

Dependent Claim 25 words

The method of claim 1 or 3 in which said perfluoropolyether has a molecular weight falling in the range of about 1,000 to about 10,000.

Claim 27

Dependent Claim 89 words

The method of claim 1 or 3 in which said amounts of the various components of said multiphase composition are such that the continuous phase of silicone fluid comprises about 10 to about 20 weight percent (wt %) of said multiphase composition and independent, polydisperse phases of water comprises about 5 to about 15 wt %, gel comprises about 35 to about 55 wt %, liquid crystal comprises about 1 to about 10 wt % and perfluoropolyether comprises about 0.5 to about 3 wt % of said multiphase composition.

Claim 28

Independent Claim 146 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier including a polyacrylamide block copolymer, a silicone-based emulsifier including dimethicone copolyol and an oleophobic, hydrophobic silicone fluid including dimethicone in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer including carbomer, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion an oil or a thermotropic liquid crystal including cholesteric esters and a perfluoropolyether including perfluoromethylisopropyl ether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Claim 29

Independent Claim 146 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier including a polyacrylamide block copolymer, a silicone-based emulsifier including dimethicone copolyol and an oleophobic, hydrophobic silicone fluid including dimethicone in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer including carbomer, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion an oil or a thermotropic liquid crystal including cholesteric esters and a perfluoropolyether including perfluoromethylisopropyl ether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Claim 30

Independent Claim 184 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier including a block copolymer of acrylamide and acrylonitrile, a silicone-based emulsifier including a mixture of cyclomethicone and dimethicone copolyol and an oleophobic, hydrophobic silicone fluid including a mixture of dimethicone and dimethiconol in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of a viscosity-enhancing, water-soluble polymer including carbomer, a second hydrophilic polymer including polyglycerylmethacrylate and an acid neutralizing amount of an amine base, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion an oil or a thermotropio liquid crystal including cholesteric esters and cholesterols, in which a vitamin is incorporated in said liquid crystal, and a perfluoropolyether including perfluoromethylisopropyl ether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Claim 31

Independent Claim 184 words

A method of forming a stable, multiphase composition comprising: (a) mixing an aqueous solution of a water-soluble polymeric emulsifier including a block copolymer of acrylamide and acrylonitrile, a silicone-based emulsifier including a mixture of cyclomethicone and dimethicone copolyol and an oleophobic, hydrophobic silicone fluid including a mixture of dimethicone and dimethiconol in amounts effective to form a stable water-in-silicone emulsion; (b) mixing said water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of a viscosity-enhancing, water-soluble polymer including carbomer, a second hydrophilic polymer including polyglycerylmethacrylate and an acid neutralizing amount of an amine base, said emulsion and gel being combined in amounts effective to form a dispersion in which said gel is dispersed in said emulsion; and (c) adding to said dispersion an oil or a thermotropio liquid crystal including cholesteric esters and cholesterols, in which a vitamin is incorporated in said liquid crystal, and a perfluoropolyether including perfluoromethylisopropyl ether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, liquid crystal and perfluoropolyether.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1997-04-18	1997-10-18	1998-04-19	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2001-04-18	2001-10-18	2002-04-19	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2005-04-18	2005-10-18	2006-04-19	$7700.00	Window Closed / Lapsed

Method of preparing a multiphase composition

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag