US4720353A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable pharmaceutical w/o emulsion composition
Assignee: Richardson Vicks Inc
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Filing: 1987-04-14
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Granted: 1988-01-19
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Expires: 2007-04-14
Abstract
Abstract A stable water-in-oil emulsion composition for topical therapeutic administration comprising: a. a dispersed aqueous phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein; b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid; c. an organopolysiloxane emulsifier of Formula (I) hereinafter described; d. PPG-20 Methyl Glucose Ether Distearate; and e. an active drug component for topical application.
Inventors
- 👤 Stephen R. Bell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:02
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/89; A61K8/891; A61K8/894; A61K47/00; A61K47/30; A61K47/34; A61K8/02; A61K8/04; A61K8/06; A61K8/064; A61K8/30; A61K8/60; A61K8/608; A61K9/00; A61K9/0012; A61K9/0014; A61Q; A61Q19/00; Y; Y10; Y10S; Y10S516/00; Y10S516/905; Y10S516/906
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
174 words
A stable water-in-oil emulsion composition comprising: a. a dispersed water phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein; b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid selected from the group consisting of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and mixtures thereof dissolved therein; c. an organopolysiloxane of the average formula: ##STR4## wherein R is hydrogen or C 1-4 alkyl; n is a number between 10 and 200; m is a number between 1 and 25; o is a number between 1 and 100, provided that all o>m; p is a number between 7 and 17; and the molar weight of (C 2 H 4 O--) x (C 3 H 6 O--) y R is between 250 and 2000, in which x and y are such that the weight ratio of oxyethylene (C 2 H 4 O--) groups to oxypropylene (C 3 H 6 O--) groups is between 100:0 to 20:80. d. PPG-20 Methyl Glucose Ether Distearate; and e. an effective therapeutic amount of a topically active drug.
Claim 2
Dependent Claim
174 words
A stable water-in-oil emulsion composition comprising: a. a dispersed water phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein; b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid selected from the group consisting of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and mixtures thereof dissolved therein; c. an organopolysiloxane of the average formula: ##STR4## wherein R is hydrogen or C 1-4 alkyl; n is a number between 10 and 200; m is a number between 1 and 25; o is a number between 1 and 100, provided that all o>m; p is a number between 7 and 17; and the molar weight of (C 2 H 4 O--) x (C 3 H 6 O--) y R is between 250 and 2000, in which x and y are such that the weight ratio of oxyethylene (C 2 H 4 O--) groups to oxypropylene (C 3 H 6 O--) groups is between 100:0 to 20:80. d. PPG-20 Methyl Glucose Ether Distearate; and e. an effective therapeutic amount of a topically active drug.
Claim 3
Dependent Claim
64 words
The composition of claim 1 falling within the following ranges: ______________________________________
% w/w
______________________________________
A. Oil Phase:
Mineral Oil 1-15
Organopolysiloxane 1-4
Volatile Silicone Fluid 5-30
PPG-20 Methyl Glucose Ether Distearate
1-10
B. Water Phase:
Electrolyte 0-5
Water, q.s. 100%
______________________________________ and a therapeutically effective amount of said drug in A or B or both but not exceeding 20% w/w of the total composition.
Claim 4
Dependent Claim
63 words
The composition of claim 2 where in said organopolysiloxane: R is hydrogen or methyl; n is about 25-150; m is about 1-15 ; and o is about 5-50 with o>2 m; the molar weight of (C 2 H 4 O--) x (C 3 H 6 O--) y R is about 400-1200; and the weight ratio of oxyethylene to oxypropylene groups is about 400-1200.
Claim 5
Dependent Claim
20 words
The composition of claim 2 wherein the amount of said organopolysiloxane is from about 1.5 to about 3.0 weight percent.
Claim 6
Dependent Claim
24 words
The composition of claim 2 wherein the amount of said PPG-20 Methyl Glucose Ether Distearate is from about 3 to about 8 weight percent.
Claim 7
Dependent Claim
12 words
The composition of claim 2 wherein said drug is an anti-acne agent.
Claim 8
Dependent Claim
21 words
The composition of claim 6 wherein said anti-acne agent is selected from the group consisting of benzoyl peroxide, sulfur, and resorcinol.
Claim 9
Dependent Claim
10 words
The composition of claim 2 wherein said drug is ibuprofen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-18 | 1991-07-20 | 1992-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-18 | 1995-07-20 | 1996-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-18 | 1999-07-20 | 2000-01-19 | $7700.00 | Window Closed / Lapsed |