US5294401A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Membrane type of oxygenator and method for production thereof
Assignee: Terumo Corp
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Filing: 1988-03-17
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Granted: 1994-03-15
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Expires: 2008-03-17
Abstract
Abstract A membrane type oxygenator for effecting exchange of gases with a porous gas-exchange membrane possessing minute through pores forming a path for gas, which membrane type oxygenator is characterized by the fact that minute particles are retained in the minute pores of the porous gas-exchange membrane to permit a decrease in the cross-sectional area of the path for gas and as blood anticoagulant is retained in the minute particles or between the minute particles, and it is manufactured assembling a membrane type oxygenator containing a porous gas-exchange membrane possessing minute through pores forming a path for gas, then causing a dispersion of minute particles to flow through the interior of the membrane type oxygenator thereby allowing the minute pores to retain the minute particles and permitting a decrease in the cross-sectional area of the path for gas, removing the dispersion remaining within the membrane type oxygenator, and further causing a liquid containing a blood anticoagulant to flow through the interior of the oxygenator and allowing the liquid to pass through the minute pores of the gas-exchange membrane thereby inducing deposition of the blood anticoagulant on the minute particles.
Inventors
- 👤 Kazuhiko Hagiwara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:07
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1698; B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A61M1/36; A61M1/3672; B01D69/00; B01D69/08; B01D69/14; B01D69/141; B01D71/00; B01D71/06; B01D71/26; B01D71/261; B01D2325/00; B01D2325/38; Y; Y10; Y10S; Y10S128/00; Y10S128/03; Y10S261/00; Y10S261/28
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
56 words
A membrane type oxygenator for effecting exchange of gases comprising: a porous gas-exchange membrane possessing minute through-pores for passage of gas, minute particles retained within said minute through-pores in said porous gas-exchange membrane to decrease the cross-sectional area thereof, and a blood anticoagulant retained by said minute particles or between adjacent ones of said minute particles.
Claim 2
Dependent Claim
56 words
A membrane type oxygenator for effecting exchange of gases comprising: a porous gas-exchange membrane possessing minute through-pores for passage of gas, minute particles retained within said minute through-pores in said porous gas-exchange membrane to decrease the cross-sectional area thereof, and a blood anticoagulant retained by said minute particles or between adjacent ones of said minute particles.
Claim 3
Dependent Claim
38 words
A membrane type oxygenator according to claim 1, wherein said gas-exchange membrane has a wall thickness in the range of 5 to 80 μm, and said minute through-pores having diameters in the range of 0.01 to 5 μm.
Claim 4
Dependent Claim
16 words
A membrane type oxygenator according to claim 1, wherein said gas-exchange membrane comprises hollow fiber membranes.
Claim 5
Dependent Claim
24 words
A membrane type oxygenator according to claim 3, wherein said hollow fiber membranes possess inside diameters in the range of 100 to 1,000 μm.
Claim 6
Dependent Claim
21 words
A membrane type oxygenator according to claim 1, wherein said minute particles possess diameters smaller than diameters of said minute pores.
Claim 7
Dependent Claim
40 words
A membrane type oxygenator according to claim 5, wherein said minute pores of said gas-exchange membrane are crammed with said minute particles in such a manner than gaps between adjacent ones of said minute particles form a path for gas.
Claim 8
Dependent Claim
16 words
A membrane type oxygenator according to claim 1, wherein said minute particles are formed of silica.
Claim 9
Dependent Claim
22 words
A membrane type oxygenator according to claim 1, wherein said minute particles possess diameters in the range of 20 to 10,000 Å.
Claim 10
Dependent Claim
14 words
A membrane type oxygenator according to claim 1, wherein said blood anticoagulant is heparin.
Claim 11
Dependent Claim
19 words
A membrane type oxygenator according to claim 1, wherein said gas-exchange membrane is a porous membrane made of polyolefin.
Claim 12
Dependent Claim
29 words
A membrane type oxygenator according to claim 1, wherein said gas-exchange membrane has a first surface which is coated with a water-insoluble resin at locations neighboring said minute pores.
Claim 13
Dependent Claim
62 words
A membrane type oxygenator according to claim 1, wherein said minute pores of said gas-exchange membrane are crammed with said minute particles, said gas-exchange membrane having a first surface, and wherein surfaces of said minute particles are coated with a water-insoluble resin on a side of said first surface, so as to maintain said blood anticoagulant on or between said minute particles.
Claim 14
Dependent Claim
22 words
A membrane type oxygenator according to claim 11, wherein said water-insoluble resin covers the entire said first surface of said gas-exchange membrane.
Claim 15
Dependent Claim
23 words
A membrane type oxygenator according to claim 1, wherein said gas-exchange membrane has a second surface which is coated with a hydrophobic resin.
Claim 16
Dependent Claim
20 words
A membrane type oxygenator according to claim 14, wherein said hydrophobic resin is a resin possessing high permeability to gas.
Claim 17
Dependent Claim
22 words
A membrane type oxygenator according to claim 14, wherein said hydrophobic resin covers the entire said second surface of said gas-exchange membrane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-14 | 1997-09-13 | 1998-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-14 | 2001-09-13 | 2002-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-14 | 2005-09-13 | 2006-03-15 | $7700.00 | Window Closed / Lapsed |