US4909989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gas-exchange membrane for an artificial lung
Assignee: Terumo Corp
•
Filing: 1989-03-27
•
Granted: 1990-03-20
•
Expires: 2009-03-27
Abstract
Abstract In a membrane type artificial lung using as gas-exchange membranes porous hydrophobic membranes having a wall thickness in the range of 5 to 80 μm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 μm, the minute pores of the membranes are blocked with minute particles of silica having a diameter smaller than the pore diameter and having a hydrophobic surface at least on the sides thereof intended for exposure to blood. Optionally, the gas-exchange membranes have the surfaces for exposure to blood coated with a biocompatible hydrophobic resin.
Inventors
- 👤 Hiromichi Fukazawa
- 👤 Kazuhiko Hagiwara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 03:08
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L33/00; A61L33/06; A61L33/064; B01D69/00; B01D69/14; B01D69/141; Y; Y10; Y10S; Y10S128/00; Y10S128/03; Y10S261/00; Y10S261/28
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
95 words
A gas-exchange membrane for an artificial lung comprising a porous hydrophobic membrane having a wall thickness in the range of 5 to 80 μm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 μm, wherein said porous membrane comprises minute pores blocked with minute particles of silica having a diameter smaller than said pore diameter and having a hydrophobic surface at least on a side exposed to blood, wherein said minute particles have a diameter approximately in the range of 0.003 to 1.0 μm.
Claim 2
Dependent Claim
95 words
A gas-exchange membrane for an artificial lung comprising a porous hydrophobic membrane having a wall thickness in the range of 5 to 80 μm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 μm, wherein said porous membrane comprises minute pores blocked with minute particles of silica having a diameter smaller than said pore diameter and having a hydrophobic surface at least on a side exposed to blood, wherein said minute particles have a diameter approximately in the range of 0.003 to 1.0 μm.
Claim 3
Dependent Claim
22 words
A gas-exchange membrane for an artificial lung according to claim 1, wherein said porous membrane comprises a plurality of hollow fiber membranes.
Claim 4
Dependent Claim
28 words
A gas-exchange membrane for an artificial lung according to claim 2, wherein said hollow fiber membranes have an inside diameter in the range of 100 to 1,000 μm.
Claim 5
Dependent Claim
24 words
A gas-exchange membrane for an artificial lung according to claim 1, wherein said minute pores are blocked by being filled with said minute particles.
Claim 6
Dependent Claim
30 words
A gas-exchange membrane for an artificial lung according to claim 1, wherein said minute particles are coated with a hydrophobic substance at least on the sides thereof exposed to blood.
Claim 7
Dependent Claim
22 words
A gas-exchange membrane for an artificial lung according to claim 1, wherein said porous membrane is made of an olefin type resin.
Claim 8
Dependent Claim
19 words
A gas-exchange membrane for an artificial lung according to claim 6, wherein said porous membrane is made of polypropylene.
Claim 9
Dependent Claim
125 words
A gas-exchange membrane for an artificial lung comprising a porous hydrophobic membrane having a wall thickness in the range of 5 to 80 μm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 μm wherein said porous membrane comprises minute pores blocked with minute particles made of silica and having a diameter smaller than said pore diameter and said porous membrane is coated with a biocompatible hydrophobic resin at least on a side wall exposed to blood, wherein said minute particles have a diameter approximately in the range of 0.003 to 1 μm, and wherein said biocompatible hydrophobic resin forms a coating of a wall thickness in the range of 0.0001 to 10 μm.
Claim 10
Dependent Claim
125 words
A gas-exchange membrane for an artificial lung comprising a porous hydrophobic membrane having a wall thickness in the range of 5 to 80 μm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 μm wherein said porous membrane comprises minute pores blocked with minute particles made of silica and having a diameter smaller than said pore diameter and said porous membrane is coated with a biocompatible hydrophobic resin at least on a side wall exposed to blood, wherein said minute particles have a diameter approximately in the range of 0.003 to 1 μm, and wherein said biocompatible hydrophobic resin forms a coating of a wall thickness in the range of 0.0001 to 10 μm.
Claim 11
Dependent Claim
27 words
A gas-exchange membrane for an artificial lung according to claim 8, wherein the air flux of said porous membrane is not more than 500 ml/min.m 2 .mmHg.
Claim 12
Dependent Claim
22 words
A gas-exchange membrane for an artificial lung according to claim 8, wherein said porous membrane comprises a plurality of hollow fiber membranes.
Claim 13
Dependent Claim
28 words
A gas-exchange membrane for an artificial lung according to claim 10, wherein said hollow fiber membranes have an inside diameter in the range of 100 to 1,000 μm.
Claim 14
Dependent Claim
23 words
A gas-exchange membrane for an artificial lung according to claim 8, wherein said minute pores are blocked by being filled with minute particles.
Claim 15
Dependent Claim
20 words
A gas-exchange membrane for an artificial lung according to claim 8, wherein said biocompatible hydrophobic resin is a fluorine-containing resin.
Claim 16
Dependent Claim
34 words
A gas-exchange membrane for an artificial lung according to claim 13, wherein said biocompatible hydrophobic resin is a vinyl type copolymer having as one component thereof a vinyl monomer possessing a perfluoroalkyl side chain.
Claim 17
Dependent Claim
22 words
A gas-exchange membrane for an artificial lung according to claim 14, wherein said biocompatible hydrophobic resin is a vinyl type block copolymer.
Claim 18
Dependent Claim
38 words
A gas-exchange membrane for an artificial lung according to claim 15, wherein said vinyl type block copolymer is a (meth) acrylate type copolymer having at least one component thereof a (meth) acrylate monomer possessing a perfluoroalkyl side chain.
Claim 19
Dependent Claim
51 words
A gas-exchange membrane for an artificial lung according to claim 15, wherein the weight ratio in said block copolymer of the polymer component of a vinyl monomer possessing a perfluoroalkyl side chain to the polymer component of the other monomer of said copolymer is in the range of 0.25 to 1.0.
Claim 20
Dependent Claim
28 words
A gas-exchange membrane for an artificial lung according to claim 15, wherein said perfluoroalkyl side chain is --CH 2 CH 2 (CF 2 ) 7 CF 3 .
Claim 21
Dependent Claim
22 words
A gas-exchange membrane for an artificial lung according to claim 8, wherein said porous membrane is made of an olefin type resin.
Claim 22
Dependent Claim
19 words
A gas-exchange membrane for an artificial lung according to claim 19, wherein said porous membrane is made of polypropylene.
References Cited (Backward Citations)
US4093515A
Cited
US4239729A
Cited
GB2072047A
Cited
US4374802A
Cited
JPS5944267A
Cited
US4619897A
Cited
JPS60106466A
Cited
EP0164025A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-19 | 1993-09-18 | 1994-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-19 | 1997-09-18 | 1998-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-19 | 2001-09-18 | 2002-03-20 | $7700.00 | Window Closed / Lapsed |