EP0223626A1
Expired / Lapsed
EP
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Membrane type artificial lung and method for manufacture thereof
Assignee: Terumo Corp
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Filing: 1986-09-12
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Granted: —
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Expires: 2006-09-12
Abstract
Abstract In a membrane type artificial lung using as gas-exchange membranes porous hydrophobic membranes having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.0l to 5 µm, the minute pores 3 of the membranes 2 are blocked with minute particles 4 having a diameter smaller than the pore diameter and having a hydrophobic surface at least on the sides thereof intended for exposure to blood. Optionally, the gas-exchange membranes have the surface for exposure to blood coated with a biocompatible hydrophobic resin.
Inventors
- 👤 Hiromichi Fukazawa
- 👤 Kazuhiko Terumo K.K. Fujimi-Ryo Hagiwara
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 01:29
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L33/00; A61L33/06; A61L33/064; B01D69/00; B01D69/14; B01D69/141; Y; Y10; Y10S; Y10S128/00; Y10S128/03; Y10S261/00; Y10S261/28
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
83 words
A membrane type artificial lung using as gas-exchange membranes porous hydrophobic membranes having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.0l to 5 µ m, which artificial lung is characterized in that minute pores thereof are blocked with minute particles having a diameter smaller than said pore diameter and having a hydrophobic surface at least on the sides thereof exposed to blood.
Claim 2
Dependent Claim
83 words
A membrane type artificial lung using as gas-exchange membranes porous hydrophobic membranes having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.0l to 5 µ m, which artificial lung is characterized in that minute pores thereof are blocked with minute particles having a diameter smaller than said pore diameter and having a hydrophobic surface at least on the sides thereof exposed to blood.
Claim 3
Dependent Claim
17 words
A membrane type artificial lung according to Claim l, wherein said gas-exchange membranes are hollow fiber membranes.
Claim 4
Dependent Claim
27 words
A membrane type artificial lung according to Claim 2, wherein said hollow fiber membranes have an inside diameter in the range of l00 to l,000 µ m.
Claim 5
Dependent Claim
22 words
A membrane type artificial lung according to Claim l, wherein said minute pores are blocked by being filled with said minute particles.
Claim 6
Dependent Claim
19 words
A membrane type artificial lung according to Claim l, wherein said minute particles are made of a hydrophobic substance.
Claim 7
Dependent Claim
35 words
A membrane type artificial lung according to Claim l, wherein said minute particles are made of a hydrophilic substance and are coated with a hydrophobic substance at least on the sides thereof exposed to blood.
Claim 8
Dependent Claim
20 words
A membrane type artificial lung according to Claim l, wherein said gas-exchange membranes are made of an olefin type resin.
Claim 9
Dependent Claim
17 words
A membrane type artificial lung according to Claim 7, wherein said gas-exchange membranes are made of polypropylene.
Claim 10
Dependent Claim
26 words
A membrane type artificial lung according to Claim l, wherein said minute particles have a diameter approximately in the range of 0.003 to l.0 µ m.
Claim 11
Dependent Claim
29 words
A membrane type artificial lung according to Claim 1 wherein said gas-exchange membranes are coated with a biocompatible hydrophobic resin at least on the side thereof exposed to blood.
Claim 12
Dependent Claim
25 words
A membrane type artificial lung according to Claim 10, wherein the air flux of said membrane type artificial lung is not more than 500 ml/min.m².mmHg.
Claim 13
Dependent Claim
17 words
A membrane type artificial lung according to Claim 1, wherein said minute particles are made of silica.
Claim 14
Dependent Claim
18 words
A membrane type artificial lung according to Claim 10, wherein said biocompatible hydrophobic resin is a fluorine-containing resin.
Claim 15
Dependent Claim
32 words
A membrane type artificial lung according to Claim 10, wherein said biocompatible hydrophobic resin is a vinyl type copolymer having as one component thereof a vinyl monomer possessing a perfluoroalkyl side chain.
Claim 16
Dependent Claim
20 words
A membrane type artificial lung according to Claim 10, wherein said biocompatible hydrophobic resin is a vinyl type block copolymer.
Claim 17
Dependent Claim
37 words
A membrane type artificial lung according to Claim 15, wherein said vinyl type block copolymer is a (meth) acrylate type copolymer having at least one component thereof being a (meth) acrylate monomer possessing a perfluoroalkyl side chain.
Claim 18
Dependent Claim
49 words
A membrane type artificial lung according to Claim 14, wherein the weight ratio in said block copolymer of the polymer component of a vinyl monomer possessing a perfluoroalkyl side chain to the polymer component of the other monomer of said copolymer is in the range of 0.25 to 1.0.
Claim 19
Dependent Claim
16 words
A membrane type artificial lung according to Claim 14, wherein said perfluoroalkyl side chain is -CH₂CH₂(CF₂)₇CF₃.
Claim 20
Dependent Claim
29 words
A membrane type artificial lung according to Claim 10, wherein said biocompatible hydrophobic resin forms a coating of a wall thickness in the range of 0.0001 to 10 µm.
Claim 21
Independent Claim
111 words
A method for the manufacture of a membrane type artificial lung using as gas-exchange membranes porous membranes having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 µm, which method is characterized by the steps of causing a dispersion of minute particles having a diameter smaller than said pore diameter to filter through said porous membranes thereby blocking said minute pores of said porous membranes with said minute particles, and removing the part of said dispersion remaining on the surface part of said porous membrane with a cleaning fluid.
Claim 22
Independent Claim
111 words
A method for the manufacture of a membrane type artificial lung using as gas-exchange membranes porous membranes having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, and a pore diameter in the range of 0.01 to 5 µm, which method is characterized by the steps of causing a dispersion of minute particles having a diameter smaller than said pore diameter to filter through said porous membranes thereby blocking said minute pores of said porous membranes with said minute particles, and removing the part of said dispersion remaining on the surface part of said porous membrane with a cleaning fluid.
Claim 23
Dependent Claim
16 words
A method according to claim 20, wherein said minute particles are made of a hydrophobic substance.
Claim 24
Dependent Claim
51 words
A method according to Claim 20, wherein said minute particles are made of a hydrophilic substance and, after said minute pores have been blocked with said minute particles, said minute particles are subjected, at least on the surface thereof intended for exposure to blood, to a treatment for impartation of hydrophobicity.
Claim 25
Dependent Claim
85 words
A method according to Claim 22, wherein said treatment for impartation of hydrophobicity comprises bringing a solution of hydrophobic resin into contact with at least the surface of said minute particles intended for exposure to blood, removing the part of said solution adhering to parts other than said minute particles with a cleaning liquid incapable of dissolving said hydrophobic resin, and thereafter vaporizing a solvent thereby forming a coating of said hydrophobic resin on the surface of said minute particles intended for exposure to blood.
Claim 26
Dependent Claim
46 words
A method according to Claim 20, wherein said porous membranes are hydrophobic, and brought into contact with an alcohol by way of treatment for impartation of hydrophilicity, and then a dispersion of minute particles using water as a dispersion medium is filtered through said porous membranes.
Claim 27
Dependent Claim
118 words
A method according to Claim 20, wherein said porous membranes are hollow fiber membranes, having a wall thickness in the range of 5 to 80 µm, a porosity in the range of 20 to 80%, a pore diameter in the range of 0.01 to 5 µm, and an inside diameter in the range of 100 to 1.000 µm, the minute pores in the hollow fiber porous membranes are blocked with minute particles by causing a dispersion of said minute particles to flow in the interiors of said hollow fiber porous membranes and filter through the walls thereof and wherein thereafter the part of said dispersion remaining inside said hollow fiber porous membranes is removed with a cleaning fluid.
Claim 28
Dependent Claim
25 words
A method according to Claim 25, wherein the interiors of said hollow fiber porous membranes are kept under pressure during the course of said filtration.
Claim 29
Dependent Claim
28 words
A method according to Claim 25, wherein said hollow fiber porous membranes ensure flow of a fluid in the axial direction thereof during the course of said filtration.
Claim 30
Independent Claim
58 words
A method according to one of claims 20 and 25, characterized by further bringing a solution of biocompatible hydrophobic resin to come into contact with at least the surface of said porous membranes intended for exposure to blood, and vaporizing a solvent thereby coating said surfaces of said porous membranes to be exposed to blood with said resin.
Claim 31
Dependent Claim
48 words
A method according to Claim 20 or 28, wherein said porous membranes are hydrophobic and are brought into contact with an alcohol by way of treatment for impartation of hydrophilicity before said dispersion of minute particles using water as a dispersion medium is filtered through said porous membranes.
Claim 32
Dependent Claim
18 words
A method according to Claim 28, wherein said biocompatible hydrophobic resin is a fluorine-containing resin or silicone rubber.
Claim 33
Dependent Claim
31 words
A method according to Claim 28 or 30, wherein said biocompatible hydrophobic resin is a vinyl type copolymer having as one component thereof a vinyl monomer possessing a perfluoroalkyl side chain.
References Cited (Backward Citations)
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