Patent US5279558A successfully refreshed from Google Patents.
US5279558A
Expired / Lapsed
US
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Fluid delivery apparatus with an additive
Assignee: PESCADERO BEACH HOLDINGS Corp
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Filing: 1992-12-07
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Granted: 1994-01-18
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Expires: 2012-12-07
Abstract
Abstract An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, which, in cooperation with a thin planar base, defines a fluid chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet.
Inventors
- 👤 Marshall S. Kriesel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:45
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/1407; A61M5/1409; A61M5/142; A61M5/145; A61M5/148; A61M5/152; A61M2205/00; A61M2205/19; A61M2205/192; A61M2205/197; A61M5/14244; A61M5/14248; Y; Y10; Y10S; Y10S128/00; Y10S128/12
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
163 words
A device for use in infusing fluids into an ambulatory patient at a controlled rate comprising: (a) a base having an upstanding portion including a fluid inlet passageway and a fluid outlet said fluid outlet and said fluid inlet passageways being interconnected by a fluid flow path; (b) filling means for introducing fluid into said fluid inlet passageway, said filling means including filling check valve means for controlling the flow of fluid into said fluid inlet passageway; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid inlet and said fluid outlet, said membrane being distendable by fluid introduced into said chamber under pressure through said fluid inlet, said membrane having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; (d) adding means disposed within said fluid flow path for adding an additive to fluid flowing therethrough.
Claim 2
Independent Claim
163 words
A device for use in infusing fluids into an ambulatory patient at a controlled rate comprising: (a) a base having an upstanding portion including a fluid inlet passageway and a fluid outlet said fluid outlet and said fluid inlet passageways being interconnected by a fluid flow path; (b) filling means for introducing fluid into said fluid inlet passageway, said filling means including filling check valve means for controlling the flow of fluid into said fluid inlet passageway; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid inlet and said fluid outlet, said membrane being distendable by fluid introduced into said chamber under pressure through said fluid inlet, said membrane having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; (d) adding means disposed within said fluid flow path for adding an additive to fluid flowing therethrough.
Claim 3
Dependent Claim
48 words
A device as defined in claim 1 in which said adding means comprises an additive and an additive presentation means for presenting said additive to the fluid, said additive presentation means being disposed within said fluid inlet passageway intermediate said fluid outlet and said filling check valve means.
Claim 4
Dependent Claim
40 words
A device as defined in claim 1 in which said adding means comprises an additive and an additive presentation means for presenting said additive to the fluid, said additive being removable from said additive presentation means using affinity chromotography techniques.
Claim 5
Dependent Claim
23 words
A device as defined in claim 3 in which said additive is removably connected to said additive presentation means using azlactone functional compounds.
Claim 6
Dependent Claim
30 words
A device as defined in claim 4 in which said adding means comprises a structural support disposed within a glass vial, said structural support having biologically active proteins bound thereto.
Claim 7
Independent Claim
149 words
A device for use in infusing fluids into an ambulatory patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet passageway, and a fluid passageway interconnecting said fluid inlet and said fluid outlet passageway; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid passageway, and with said membrane being distendable by fluid introduced into said chamber under pressure through said fluid inlet passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; and (d) adding means disposed within said fluid outlet passageway for adding an additive to fluid flowing therethrough, said adding means comprising a support and an additive removably connected to said support.
Claim 8
Independent Claim
149 words
A device for use in infusing fluids into an ambulatory patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet passageway, and a fluid passageway interconnecting said fluid inlet and said fluid outlet passageway; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid passageway, and with said membrane being distendable by fluid introduced into said chamber under pressure through said fluid inlet passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; and (d) adding means disposed within said fluid outlet passageway for adding an additive to fluid flowing therethrough, said adding means comprising a support and an additive removably connected to said support.
Claim 9
Dependent Claim
21 words
A device as defined in claim 6 in which said additive is substantially removable from said support using affinity chromotography techniques.
Claim 10
Dependent Claim
25 words
A device as defined in claim 7 in which a ligand is connected to said support and a target molecule is connected to said ligand.
Claim 11
Dependent Claim
28 words
A device as defined in claim 8 in which a spacer arm is connected to said support and in which a ligand is connected to said spacer arm.
Claim 12
Dependent Claim
17 words
A device as defined in claim 9 in which an enzyme is connected to said target molecule.
Claim 13
Dependent Claim
15 words
A device as defined in claim 9 in which said target molecule is a protein.
Claim 14
Dependent Claim
16 words
A device as defined in claim 11 in which an antibody is bound to said protein.
Claim 15
Independent Claim
172 words
A device for use in infusing beneficial agents into a patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet passageway and a fluid passageway interconnecting said fluid inlet and said fluid outlet; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid outlet passageway, said membrane distendable by fluid introduced into said chamber under pressure through said fluid passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; (d) adding means mounted within said fluid outlet passageway for adding an additive to fluid introduced by said filling means, said adding means comprising: (i) additive presentation means disposed within said fluid passageway for presenting an additive to the fluid flowing therethrough; and (ii) an additive substantially removably interconnected to said additive presentation means using affinity chromotography immobilization techniques.
Claim 16
Independent Claim
172 words
A device for use in infusing beneficial agents into a patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet passageway and a fluid passageway interconnecting said fluid inlet and said fluid outlet; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid outlet passageway, said membrane distendable by fluid introduced into said chamber under pressure through said fluid passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; (d) adding means mounted within said fluid outlet passageway for adding an additive to fluid introduced by said filling means, said adding means comprising: (i) additive presentation means disposed within said fluid passageway for presenting an additive to the fluid flowing therethrough; and (ii) an additive substantially removably interconnected to said additive presentation means using affinity chromotography immobilization techniques.
Claim 17
Dependent Claim
16 words
A device as defined in claim 13 in which said filling means comprises a syringe assembly.
Claim 18
Dependent Claim
27 words
A device as defined in claim 13 in which said filling means comprises a needle assembly having a hollow needle connectable with a source of eluting fluid.
Claim 19
Dependent Claim
45 words
A device as defined in claim 13 in which said base includes an upstanding portion defining said fluid outlet passageway, said adhesive presentation means being receivable within said upstanding portion so that said additive will be exposed to fluid flowing through said fluid outlet passageway.
Claim 20
Dependent Claim
17 words
A device as defined in claim 16 in which said upstanding portion extends transversely of said base.
Claim 21
Dependent Claim
17 words
A device as defined in claim 16 in which said upstanding portion extends longitudinally of said base.
Claim 22
Dependent Claim
48 words
A device as defined in claim 16 in which said additive presentation means is contained within a glass vial receivable within said upstanding portion and in which said adding means further includes flow rate control means for controlling the rate of fluid flowing toward said additive presentation means.
Claim 23
Dependent Claim
49 words
A device as defined in claim 16 in which said additive presentation means is contained within a glass vial receivable within said upstanding portion and in which said adding means further includes flow rate control means for controlling the rate of fluid flowing away from said additive presentation means.
Claim 24
Dependent Claim
32 words
A device as defined in claim 13 in which said additive is removably connected to said additive presentation means using an immobilized ligand and a spacer arm means comprises a syringe assembly.
Claim 25
Dependent Claim
29 words
A device as defined in claim 13 in which said adding means comprises an additive which provides for extended release of a beneficial agent to the fluid over time.
Claim 26
Dependent Claim
22 words
A device as defined in claim 13 in which said additive presentation means provides for extended release of said additive over time.
Claim 27
Independent Claim
166 words
A device for use in infusing beneficial agents into a patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet and a fluid passageway interconnecting said fluid inlet and said fluid outlet; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid passageway, said membrane being distendable by fluid introduced into said chamber under pressure through said fluid passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; and (d) adding means for adding an additive to fluid introduced by said filling means, said adding means comprising: (i) additive presentation means disposed within said fluid passageway for presenting an additive to the fluid flowing therethrough; and (ii) an additive removably interconnected to said additive presentation means for removal using affinity chromotography techniques.
Claim 28
Independent Claim
166 words
A device for use in infusing beneficial agents into a patient at a controlled rate comprising: (a) a base having a fluid inlet, a fluid outlet and a fluid passageway interconnecting said fluid inlet and said fluid outlet; (b) filling means for introducing fluid into said fluid inlet; (c) a distendable membrane constructed of an elastic material which is fitted over said base to define a chamber in communication with said fluid passageway, said membrane being distendable by fluid introduced into said chamber under pressure through said fluid passageway and having a tendency to return to a less distended configuration whereby fluid within said chamber will be expelled through said fluid outlet; and (d) adding means for adding an additive to fluid introduced by said filling means, said adding means comprising: (i) additive presentation means disposed within said fluid passageway for presenting an additive to the fluid flowing therethrough; and (ii) an additive removably interconnected to said additive presentation means for removal using affinity chromotography techniques.
Claim 29
Dependent Claim
29 words
A device as defined in claim 24 in which said adding means comprises an additive which provides for extended release of a beneficial agent to the fluid over time.
Claim 30
Dependent Claim
22 words
A device as defined in claim 24 in which said additive presentation means provides for extended release of said additive over time.
Claim 31
Dependent Claim
17 words
A device as defined in claim 24 in which said additive presentation means comprises an immobilized ligand.
Claim 32
Dependent Claim
17 words
A device as defined in claim 27 in which a target molecule is affixed to said ligand.
Claim 33
Dependent Claim
17 words
A device as defined in claim 24 in which said additive presentation means comprises a spacer arm.
Claim 34
Dependent Claim
17 words
A device as defined in claim 29 in which a protein is connected to said spacer arm.
Claim 35
Dependent Claim
16 words
A device as defined in claim 30 in which an antibody is connected to said protein.
Claim 36
Dependent Claim
16 words
A device as defined in claim 30 in which a immunoglobulin is connected to said protein.
Claim 37
Dependent Claim
27 words
A device as defined in claim 30 in which an antibody is covalently attached to said protein, said antibody having binding sites facing outwardly from said protein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-17 | 1997-07-19 | 1998-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-17 | 2001-07-19 | 2002-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-17 | 2005-07-19 | 2006-01-18 | $7700.00 | Window Closed / Lapsed |