US5240710A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating conditions of teeth and their supporting tissue with sucralfate
Assignee: Tandlaegeselskabet Jesper Hamberger ApS
•
Filing: 1992-09-04
•
Granted: 1993-08-31
•
Expires: 2012-09-04
Abstract
Abstract The use of a sulphated saccharide or a salt or a complex thereof as an ingredient in a topical preparation for the prophylaxis or treatment of diseases or conditions of the tooth or tooth-supporting tissue, in particular for the prophylaxis or treatment of inflammatory and plaque-related conditions, a method of preventing or treating such diseases or conditions by topically applying the sulphated saccharide or salt or complex thereof, and a topical preparation containing the sulphated saccharide or salt or complex thereof for the prophylaxis or treatment of such diseases or conditions. The sulphated saccharide is especially a polysulphated or persulphated saccharide. e.g. sucralfate (sucrose octakis(hydrogen sulphate) aluminum complex) or a sodium and/or potassium salt of sucrose octakis(hydrogen sulphate). The preparation may be in the form of a solution, suspension, salve, paste, powder, gel, cream, dental fixative, periodontal implant, chewing gum, chewable tablet, effervescent tablet or lozenge.
Inventors
- 👤 Daniel K. Bar-Shalom
- 👤 Niels Bukh
- 👤 Jesper Hamburger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7024; A61K8/00; A61K8/18; A61K8/19; A61K8/22; A61K8/30; A61K8/60; A61K8/64; A61K8/65; A61K8/72; A61K8/73; A61K8/731; A61K8/735; A61P; A61P1/00; A61P1/02; A61P25/00; A61P25/04; A61Q; A61Q11/00
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
51 words
A method of preventing, diminishing or treating dental disease in a human, which comprises topically administering into the oral cavity a salve, paste, gel or cream preparation comprising a prophylactically or therapeutically effective amount of an aluminum salt or complex of a sulfated saccharide, said preparation being suitable for dental use.
Claim 2
Independent Claim
51 words
A method of preventing, diminishing or treating dental disease in a human, which comprises topically administering into the oral cavity a salve, paste, gel or cream preparation comprising a prophylactically or therapeutically effective amount of an aluminum salt or complex of a sulfated saccharide, said preparation being suitable for dental use.
Claim 3
Dependent Claim
11 words
The method of claim 1, wherein the saccharide is an oligosaccharide.
Claim 4
Dependent Claim
20 words
The method of claim 2, wherein the oligosaccharide is selected from the group consisting of sucrose, lactose, maltose, and cellobiose.
Claim 5
Dependent Claim
10 words
The method of claim 1, wherein the saccharide is polysulphated.
Claim 6
Dependent Claim
10 words
The method of claim 4, wherein the saccharide is persulfated.
Claim 7
Dependent Claim
15 words
The method of claim 1, wherein the aluminum is in the form of aluminum hydroxide.
Claim 8
Dependent Claim
14 words
A method of claim 1, wherein the sulphated saccharide is an aluminum disaccharide polysulphate.
Claim 9
Dependent Claim
11 words
The method of claim 7, wherein the sulphated saccharide is sucralfate.
Claim 10
Dependent Claim
15 words
The method of claim 1, wherein the sulphated saccharide is formulated as a topical preparation.
Claim 11
Dependent Claim
14 words
The method of claim 9, wherein the topical preparation additionally contains a non-sulphated polysaccharide.
Claim 12
Dependent Claim
22 words
The method of claim 9, wherein the preparation comprises an adhesive which is capable of adhering to the teeth or tooth-supporting tissue.
Claim 13
Dependent Claim
11 words
The method of claim 9, wherein the topical preparation is biodegradable.
Claim 14
Dependent Claim
49 words
The method of claim 1, wherein the disease is selected from the group consisting of dental caries, dental plaque, gingivitis, periodontitis, alveolitis, pulpitis, osteomyelitis, post-extractive or post-surgical wounds, tooth eruption, bone resorption, prosthetic irritation, cysts or neoplasms originating is the tooth-supporting tissue, and bacterial, mycotic, and viral oral infections.
Claim 15
Dependent Claim
26 words
The method of claim 9, wherein the topical preparation has a form selected from the group consisting of a salve, a paste, a gel, a cream.
Claim 16
Dependent Claim
61 words
The method of claim 9, wherein the topical preparation is administered together with one or more other active agents selected from the group consisting of an antibiotic, and antibacterial or antimicrobial agent, an antiviral agent, an antimycotic agent, a bacteriostatic agent, an antiseptic agent, a disinfectant, a local anesthetic or analgesic, an anti-inflammatory agent, an antineoplastic agent, and an anticarious agent.
Claim 17
Dependent Claim
12 words
The method of claim 10 wherein the non-sulfated polysaccharide is hyaluronic acid.
Claim 18
Dependent Claim
24 words
The method of claim 1 wherein the concentration of sulfated saccharide in the preparation is at least about 1% by weight of the preparation.
Claim 19
Dependent Claim
37 words
The method of claim 9 wherein the preparation contains a high molecular weight material selected from the group consisting of pectin, gelatine and methylcellulose, and a triglyceride comprising acid moieties of a length of 14-18 carbon atoms.
Claim 20
Dependent Claim
13 words
The method of claim 1 in which the preparation is a dental paste.
Claim 21
Dependent Claim
43 words
A topical salve, paste, gel or cream preparation useful in preventing or treating dental disease in a human which comprises a prophylactically or therapeutically effective amount of an aluminum salt or complex of a sulfated saccharide, said preparation being suitable for dental use.
Claim 22
Dependent Claim
43 words
A topical salve, paste, gel or cream preparation useful in preventing or treating dental disease in a human which comprises a prophylactically or therapeutically effective amount of an aluminum salt or complex of a sulfated saccharide, said preparation being suitable for dental use.
Claim 23
Dependent Claim
11 words
The preparation of claim 20, which additionally contains a pharmaceutical excipient.
Claim 24
Dependent Claim
11 words
The preparation of claim 20, wherein the saccharide is an oligosaccharide.
Claim 25
Dependent Claim
20 words
The preparation of claim 20, wherein the oligosaccharide is selected from the group consisting of sucrose, lactose, maltose and cellobiose.
Claim 26
Dependent Claim
10 words
The preparation of claim 20, wherein the saccharide is polysulphated.
Claim 27
Dependent Claim
10 words
The preparation of claim 24, wherein the saccharide is persulfated.
Claim 28
Dependent Claim
15 words
The preparation of claim 20, wherein the aluminum is in the form of aluminum hydroxide.
Claim 29
Dependent Claim
14 words
The preparation of claim 20, wherein the sulphated saccharide is an aluminum disaccharide polysulphate.
Claim 30
Dependent Claim
11 words
The preparation of claim 27, wherein the sulphated saccharide is sucralfate.
Claim 31
Dependent Claim
14 words
A preparation of claim 20, wherein the topical preparation additionally contains a non-sulphated polysaccharide.
Claim 32
Dependent Claim
22 words
The preparation of claim 20, wherein the preparation comprises an adhesive which is capable of adhering to the teeth or tooth-supporting tissue.
Claim 33
Dependent Claim
11 words
The preparation of claim 20, wherein the topical preparation is biodegradable.
Claim 34
Dependent Claim
49 words
The preparation of claim 20, wherein the disease is selected from the group consisting of dental caries, dental plaque, gingivitis, periodontitis, alveolitis, pulpitis, osteomyelitis, post-extractive or post-surgical wounds, tooth eruption, bone resorption, prosthetic irritation, cysts or neoplasms originating in the tooth-supporting tissue, and bacterial, mycotic, and viral oral infections.
Claim 35
Dependent Claim
26 words
The preparation of claim 20, wherein the topical preparation has a form selected from the group consisting of a salve, a paste, a gel, a cream.
Claim 36
Dependent Claim
23 words
The preparation of claim 20, wherein the concentration of sulphated saccharide is from about 0.01 to about 75% by weight of the preparation.
Claim 37
Dependent Claim
12 words
The preparation of claim 29 wherein the non-sulfated polysaccharide is hyaluronic acid.
Claim 38
Dependent Claim
24 words
The preparation of claim 20 wherein the concentration of sulfated saccharide in the preparation is at least about 1% by weight of the preparation.
Claim 39
Dependent Claim
35 words
The preparation of claim 20 which contains a high molecular weight material selected from the group consisting of pectin, gelatine and methyl-cellulose, and a triglyceride comprising acid moieties of a length of 12-18 carbon atoms.
Claim 40
Dependent Claim
13 words
The preparation of claim 20 which is further characterized as a dental paste.
Claim 41
Independent Claim
43 words
A method of inhibiting the formation of dental plaque which comprises introducing into the oral cavity of a patient a preparation comprising a prophylactically effective amount of a sulfated saccharide, or a salt or complex thereof, said preparation being suitable for dental use.
Claim 42
Independent Claim
43 words
A method of inhibiting the formation of dental plaque which comprises introducing into the oral cavity of a patient a preparation comprising a prophylactically effective amount of a sulfated saccharide, or a salt or complex thereof, said preparation being suitable for dental use.
Claim 43
Dependent Claim
11 words
The method of claim 39 wherein the saccharide is an oligosaccharide.
Claim 44
Dependent Claim
23 words
The method of claim 39 wherein the preparation comprises a prophylactically effective amount of an aluminum salt or complex of a sulfate saccharide.
Claim 45
Dependent Claim
15 words
The method of claim 41 wherein the preparation comprises a prophylactically effective amount of sucralfate.
Claim 46
Dependent Claim
16 words
The method of claim 39 wherein the preparation is a dental salve, paste, gel or cream.
Claim 47
Dependent Claim
24 words
The method of claim 39 wherein the concentration of sulfated saccharide in the preparation comprises at least about 1% by weight of the preparation.
Claim 48
Dependent Claim
31 words
The method of claim 39 wherein the preparation further comprises an adhesive and is applied to and adheres to the gingiva, periodontal sulcus/pocket, tooth enamel, dentine, root cement or tooth-supporting tissue.
Claim 49
Dependent Claim
10 words
The method of claim 45 wherein the preparation is biodegradable.
Claim 50
Dependent Claim
11 words
The method of claim 1 wherein the dental disease is gingivitis.
Claim 51
Dependent Claim
47 words
A toothpaste useful in preventing or treating dental disease in a human which comprises a therapeutically effective amount of sucralfate, which is from about 0.1 to about 20% by weight, solubilized in about 0.05 to about 10% by weight of a water-soluble non-soap synthetic organic detergent preparation.
Claim 52
Dependent Claim
47 words
A toothpaste useful in preventing or treating dental disease in a human which comprises a therapeutically effective amount of sucralfate, which is from about 0.1 to about 20% by weight, solubilized in about 0.05 to about 10% by weight of a water-soluble non-soap synthetic organic detergent preparation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-30 | 1997-03-01 | 1997-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-30 | 2001-03-01 | 2001-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-30 | 2005-03-01 | 2005-08-31 | $7700.00 | Window Closed / Lapsed |