EP0230023A2
Expired / Lapsed
EP
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Pharmaceutical compositions for the enhancement of wound healing
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1986-12-19
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Granted: —
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Expires: 2006-12-19
Abstract
Abstract Pharmaceutical composition comprising sulfated oligosaccharides, particularly mono- and disaccharides, or their salts to enhance healing of wounds are described. Preferred saccharides are those having three or more sulfate groups, with persulfation being most preferred. Preferred salts are the soluble salts most preferably the alkali metal salts, particularly potassium and sodium salts. Sucrose octasulfate is the most preferred material. The saccharides may be present in any form, including liquids, gels or time release polymers. In preferred practice the saccharide is present in combination with collagen.
Inventors
- 👤 Dov Michaeli
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 20:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; C; C07; C07H; C07H11/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
25 words
Process for preparing a pharmaceutical composition comprising combining a compound selected from synthetic polysulfated oligosaccharides and their pharmaceutically acceptable salts with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
25 words
Process for preparing a pharmaceutical composition comprising combining a compound selected from synthetic polysulfated oligosaccharides and their pharmaceutically acceptable salts with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
9 words
The process of Claim 1 comprising further combining collagen.
Claim 4
Dependent Claim
18 words
The process of Claims 1 or 2 wherein the oligosaccharide is a monosaccharide or a disaccharide, preferably sucrose.
Claim 5
Dependent Claim
19 words
The process of any one of Claims 1 to 3 wherein the oligosaccharide contains three or more sulfate groups.
Claim 6
Dependent Claim
10 words
The process of Claim 4 wherein the oligosaccharide is persulfated.
Claim 7
Dependent Claim
13 words
The process of Claims 1 or 2 wherein the polysulfated oligosaccharide-is sucrose octasulfate.
Claim 8
Dependent Claim
22 words
The process of any one of Claims 1 to 6 wherein the oligosaccharide is present in the composition in a liquid form.
Claim 9
Dependent Claim
26 words
The process of any one of Claims 1 to 7 wherein the oligosaccharide is present in the composition at a concentration of 0.1 to 1.0 mg/ml.
Claim 10
Dependent Claim
19 words
The process of Claim 6 wherein sucrose octasulfate is present in the composition at a concentration of 0.28 mg/ml.
Claim 11
Dependent Claim
26 words
The process of Claim 1 wherein the oligosaccharide is encapsulated in a polymer or other carrier which is capable of effecting sustained release of the oligosaccharide.
Claim 12
Dependent Claim
24 words
A process for preparing alkali metal sucrose octasulfate comprising reacting pyridine sulfur trioxide with sucrose and adding alkali metal hydroxide to the reaction product.
Claim 13
Dependent Claim
24 words
A process for preparing alkali metal sucrose octasulfate comprising reacting pyridine sulfur trioxide with sucrose and adding alkali metal hydroxide to the reaction product.
References Cited (Backward Citations)
No citation records indexed.
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