US4912093A
Expired / Lapsed
US
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Use of synthetic sulfated saccharides to enhance wound healing
Assignee: Marion Laboratories Inc
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Filing: 1986-10-23
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Granted: 1990-03-27
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Expires: 2006-10-23
Abstract
Abstract The use of sulfated oligosaccharides, particularly mono- and disaccharides, and their salts to enhance healing of wounds is described. Preferred saccharides are those having three or more sulfate groups, with persulfation being most preferred. Preferred salts are the soluble salts most preferably the alkali metal salts, particularly potassium and sodium salts. Sucrose octosulfate is the most preferred material. The saccharides may be used in any form, including liquids, gels or time release polymers. In preferred practice the saccharide is used in combination with collagen. Wounds, in particular those ocurring in the skin and bone tissues, may be treated with the compositions. Wound healing is promoted even in wounds, such as decubitis ulcers, which are commonly resistent to the natural healing process.
Inventors
- 👤 Dov Michaeli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 15:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; C; C07; C07H; C07H11/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
39 words
A method for promoting wound healing comprising topically applying to a wound an effective amount of a compound selected from the group consisting of synthetic polysulfated monosaccharides and oligosaccharides and their pharmaceutically acceptable salts in a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
39 words
A method for promoting wound healing comprising topically applying to a wound an effective amount of a compound selected from the group consisting of synthetic polysulfated monosaccharides and oligosaccharides and their pharmaceutically acceptable salts in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the oligosaccharide contains three or more sulfate groups.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein the compound is a disaccharide or monosaccharide.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein the oligosaccharide is persulfated.
Claim 6
Dependent Claim
10 words
The method of claim 3 wherein the disaccharide is sucrose.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the polysulfated oligosaccharide is sucrose octasulfate.
Claim 8
Dependent Claim
15 words
The method of claim 1 or 6 wherein the salt is an alkali metal salt.
Claim 9
Dependent Claim
16 words
The method of claim 1 or 6 wherein the salt is a potassium or sodium salt.
Claim 10
Dependent Claim
14 words
The method of claim 1 wherein the oligosaccharide is applied in a liquid form.
Claim 11
Dependent Claim
10 words
The method of claim 9 wherein the liquid is water.
Claim 12
Dependent Claim
12 words
The method of claim 9 wherein the liquid is isotonic salt solution.
Claim 13
Dependent Claim
18 words
The method of claim 9 wherein the oligosaccharide is present at a concentration of 0.1 to 1.0 mg/ml.
Claim 14
Dependent Claim
16 words
The method of claim 9 wherein sucrose octasulfate is present at a concentration of 0.28 mg/ml.
Claim 15
Dependent Claim
14 words
The method of claim 1 wherein the oligosaccharide is applied in combination with collagen.
Claim 16
Dependent Claim
18 words
The method of claim 14 wherein the combination of collagen and oligosaccharide is applied as a liquid suspension.
Claim 17
Dependent Claim
14 words
The method of claim 15 wherein the suspension contains 2 to 15 mg/ml collagen.
Claim 18
Dependent Claim
23 words
The method of claim 16 wherein the suspension comprises 0.28 mg/ml sucrose octasulfate and 8.75 mg/ml collagen suspended in an isotonic salt solution.
Claim 19
Dependent Claim
26 words
The method of claim 1 wherein the oligosaccharide is encapsulated in a polymer or other carrier which is capable of effecting sustained release of the oligosaccharide.
Claim 20
Dependent Claim
14 words
The method of claim 1 wherein healing of skin or bone wounds is promoted.
Claim 21
Dependent Claim
16 words
The method of claim 1 wherein the compound is applied to a wound in a bone.
Claim 22
Independent Claim
46 words
A method of promoting wound healing by means of neovascularization and fibroblast migration comprising topically applying to a wound an effective amount of a compound selected from the group consisting of synthetic polysulfated monosaccharides and oligosaccharides and their pharmaceutically acceptable salts in a pharmaceutically acceptable carrier.
Claim 23
Independent Claim
46 words
A method of promoting wound healing by means of neovascularization and fibroblast migration comprising topically applying to a wound an effective amount of a compound selected from the group consisting of synthetic polysulfated monosaccharides and oligosaccharides and their pharmaceutically acceptable salts in a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-26 | 1993-09-25 | 1994-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-26 | 1997-09-25 | 1998-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-26 | 2001-09-25 | 2002-03-27 | $7700.00 | Window Closed / Lapsed |