US5238683A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs
Assignee: United States Department of Health and Human Services
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Filing: 1989-11-24
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Granted: 1993-08-24
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Expires: 2009-11-24
Abstract
Abstract An aerosol preparation of reduced glutathione (GSH) is provided to augment the level of GSH in the lungs. Treatment of pulmonary conditions, where reduced level of GSH is found, by the aerosol preparation of the present invention is taught.
Inventors
- 👤 Ronald G. Crystal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 12:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/0078; A61K38/00; A61K38/04; A61K38/06; A61K38/063; A61P; A61P11/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
31 words
An effective amount of reduced Glutathione (GSH) in a pharmaceutically acceptable carrier, in the form of an aerosol suitable for administration by inhalation, for augmenting the GSH level in the lungs.
Claim 2
Dependent Claim
31 words
An effective amount of reduced Glutathione (GSH) in a pharmaceutically acceptable carrier, in the form of an aerosol suitable for administration by inhalation, for augmenting the GSH level in the lungs.
Claim 3
Dependent Claim
62 words
The aerosol of claim 1 comprising about 10 mg to about 2,500 mg of GSH in sterile, about 0.9% in terms of weight by volume, of sodium chloride solution, contained in a sterile pneumatic aerosol generator reservoir, so that an aerosol of said GSH is produced at the rate of about 8-12 liters per minute at about 30-50 psi of compressed air.
Claim 4
Dependent Claim
20 words
The aerosol of claim 2 produced at about 10 liters per minute at about 40 psi of the compressed air.
Claim 5
Dependent Claim
21 words
A method for augmenting GSH level in the lungs, comprising administering the aerosol of claim 1 through inhalation to the lungs.
Claim 6
Dependent Claim
40 words
A method for combating pulmonary dysfunction, disorder or disease where augmented level of GSH is deemed desirable, comprising administering the aerosol of claim 1 through inhalation to the lungs in an amount sufficient to augment GSH level in the lungs.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-23 | 1997-02-22 | 1997-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-23 | 2001-02-22 | 2001-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-23 | 2005-02-22 | 2005-08-24 | $7700.00 | Window Closed / Lapsed |