Cosmetic compositions for treating the hair containing S-substituted derivatives of glutathione

Claim 2

A process for treating the scalp and skin, characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum thereby effectively reducing a greasy appearance of the hair and skin comprising topically applyng to the scalp or skin in amounts effective to substantially reduce said greasy appearance of the hair and skin a composition comprising a mixture of an inert, nontoxic carrier selected from the group consisting of water, a lower alkanol, an aqueous solution of a lower alkanol and in an amount of about 0.1 - 5 percent by weight of said composition a component selected from the group consisting of: (i') a compound of the formula ##EQU1## where R' is selected from the group consisting of hydrogen, --CONH 2 and --COA wherein A is selected from the group consisting of alkyl having 1-18 carbon atoms and alkenyl having 2 to 18 carbon atoms, and t is 1 or 2 and a. when t = 1, R is selected from the group consisting of:

Claim 3

linear or branched alkyl having from 1 to 18 carbon atoms, 2. alkenyl having from 3 to 18 carbon atoms, 3. alkyl having from 2 to 4 carbon atoms and substituted by 1-2 hydroxy groups, 4. ##EQU2##

Claim 4

linear or branched alkyl having from 1 to 18 carbon atoms, 2. alkenyl having from 3 to 18 carbon atoms, 3. alkyl having from 2 to 4 carbon atoms and substituted by 1-2 hydroxy groups, 4. ##EQU2##

Claim 5

wherein m is 1 or 2 and R" is lower alkyl having 1-4 carbon atoms, 5. ##EQU3## wherein R'" is selected from the group consisting of -CONH 2 and -COA wherein A has the meaning given above,

Claim 6

wherein m is 1 or 2 and R" is lower alkyl having 1-4 carbon atoms, 5. ##EQU3## wherein R'" is selected from the group consisting of -CONH 2 and -COA wherein A has the meaning given above,

Claim 7

--(CH 2 ) n --NH--R 1 , wherein n is 2 or 3 and R 1 is selected from the group consisting of hydrogen, --CONH 2 , --COR 2 and --SO 2 R 3 wherein R 2 is selected from the group consisting of hydrogen, alkyl having 1- 18 carbon atoms, alkenyl having 2 to 18 carbon atoms, --CF 3 , --CH 2 --C 6 H 5 , ##SPC7## wherein R 7 is selected from the group consisting of hydrogen, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms and hydrogen and R 3 is selected from the group consisting of alkyl having 1-4 carbon atoms and ##SPC8## wherein R 7 has the meaning given above, 7. --(CH 2 ) p --R 4 wherein p is 0, 1 or 2 and R 4 is selected from the group consisting of i. 1-naphthyl when p = 0 or 1, ii. 2-naphthyl when p = 0 or 1, iii. ##SPC9## when p = 0, 1 or 2, wherein q is 1, 2 or 3 and a'. when q is 1, 2 or 3, R 5 is selected from the group consisting of hydrogen, halogen, alkoxy having 1-5 carbon atoms and alkyl having 1-4 carbon atoms and b'. when q is only 1, R 5 is selected from the group consisting of dialkylamino wherein the alkyl moiety has 1-3 carbon atoms, phenoxy, cyclohexyl, amino, phenyl, alkylthio wherein the alkyl moiety has 1-5 carbon atoms, alkylsulfinyl wherein the alkyl moiety has 1-5 carbon atoms and trifluoromethyl, 8. --CH 2 --CH 2 --CH 2 --C 6 H 5 , 9. --ch (c 6 h 5 ) 2 ,

Claim 8

--(CH 2 ) n --NH--R 1 , wherein n is 2 or 3 and R 1 is selected from the group consisting of hydrogen, --CONH 2 , --COR 2 and --SO 2 R 3 wherein R 2 is selected from the group consisting of hydrogen, alkyl having 1- 18 carbon atoms, alkenyl having 2 to 18 carbon atoms, --CF 3 , --CH 2 --C 6 H 5 , ##SPC7## wherein R 7 is selected from the group consisting of hydrogen, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms and hydrogen and R 3 is selected from the group consisting of alkyl having 1-4 carbon atoms and ##SPC8## wherein R 7 has the meaning given above, 7. --(CH 2 ) p --R 4 wherein p is 0, 1 or 2 and R 4 is selected from the group consisting of i. 1-naphthyl when p = 0 or 1, ii. 2-naphthyl when p = 0 or 1, iii. ##SPC9## when p = 0, 1 or 2, wherein q is 1, 2 or 3 and a'. when q is 1, 2 or 3, R 5 is selected from the group consisting of hydrogen, halogen, alkoxy having 1-5 carbon atoms and alkyl having 1-4 carbon atoms and b'. when q is only 1, R 5 is selected from the group consisting of dialkylamino wherein the alkyl moiety has 1-3 carbon atoms, phenoxy, cyclohexyl, amino, phenyl, alkylthio wherein the alkyl moiety has 1-5 carbon atoms, alkylsulfinyl wherein the alkyl moiety has 1-5 carbon atoms and trifluoromethyl, 8. --CH 2 --CH 2 --CH 2 --C 6 H 5 , 9. --ch (c 6 h 5 ) 2 ,

Claim 9

--ch 2 --ch = ch - c 6 h 5 , 11. --ch (c 6 h 4 p-OCH 3 ) 2 , 12. --c (ch 3 ) 2 (c 6 h 4 p-OCH 3 ), 13. --(ch 2 ) s --COR 6 wherein s is an integer of 1-4 and R 6 is selected from the group consisting of OH, NH 2 , diethylamino and dimethylamino, and 14. 1,2-dicarboxyethyl b. when t = 2, R is selected from the group consisting of 15. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3, 16. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3 and substituted by 1 or 2 OH functions, 17. butenylene, and 18. --(CH 2 ) 2 --SO 2 --(CH 2 ) 2 --, and ii'. the acid salts of the compound defined in (i').

Claim 10

--ch 2 --ch = ch - c 6 h 5 , 11. --ch (c 6 h 4 p-OCH 3 ) 2 , 12. --c (ch 3 ) 2 (c 6 h 4 p-OCH 3 ), 13. --(ch 2 ) s --COR 6 wherein s is an integer of 1-4 and R 6 is selected from the group consisting of OH, NH 2 , diethylamino and dimethylamino, and 14. 1,2-dicarboxyethyl b. when t = 2, R is selected from the group consisting of 15. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3, 16. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3 and substituted by 1 or 2 OH functions, 17. butenylene, and 18. --(CH 2 ) 2 --SO 2 --(CH 2 ) 2 --, and ii'. the acid salts of the compound defined in (i').

Claim 11

The process of claim 1 wherein said composition also includes in amounts of about 4-15 percent by weight of said composition is detergent selected from the group consisting of anionic, cationic, non-ionic and amphoteric detergents, said composition having a pH of about 3-8.

Claim 12

A process for treating the scalp and skin characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum thereby effectively reducing a greasy appearance of the hair and skin comprising orally administering to a human being having a scalp or skin so characterized a composition comprising a mixture of an ingestible carrier selected from the group consisting of water, an aqueous solution of a non-toxic lower alkanol and an ingestible solid excipient and in an amount of about 1-10 percent by weight of said composition, a component selected from the group consisting of i'. a compound of the formula ##STR11## where R' is selected from the group consisting of hydrogen, --CONH 2 and --COA wherein A is selected from the group consisting of alkyl having 1-18 carbon atoms and alkenyl having 2 to 18 carbon atoms, and t is 1 or 2 and a. when t = 1, R is selected from the group consisting of:

Claim 13

A process for treating the scalp and skin characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum thereby effectively reducing a greasy appearance of the hair and skin comprising orally administering to a human being having a scalp or skin so characterized a composition comprising a mixture of an ingestible carrier selected from the group consisting of water, an aqueous solution of a non-toxic lower alkanol and an ingestible solid excipient and in an amount of about 1-10 percent by weight of said composition, a component selected from the group consisting of i'. a compound of the formula ##STR11## where R' is selected from the group consisting of hydrogen, --CONH 2 and --COA wherein A is selected from the group consisting of alkyl having 1-18 carbon atoms and alkenyl having 2 to 18 carbon atoms, and t is 1 or 2 and a. when t = 1, R is selected from the group consisting of:

Claim 14

linear or branched alkyl having from 1 to 18 carbon atoms, 2. alkenyl having from 3 to 18 carbon atoms, 3. alkyl having from 2 to 4 carbon atoms and substituted by 1-2 hydroxy groups, 4. ##STR12##

Claim 15

linear or branched alkyl having from 1 to 18 carbon atoms, 2. alkenyl having from 3 to 18 carbon atoms, 3. alkyl having from 2 to 4 carbon atoms and substituted by 1-2 hydroxy groups, 4. ##STR12##

Claim 16

wherein m is 1 or 2 and R" is lower alkyl having 1-4 carbon atoms, 5. ##STR13## wherein R'" is selected from the group consisting of --CONH 2 and --COA wherein A has the meaning given above,

Claim 17

wherein m is 1 or 2 and R" is lower alkyl having 1-4 carbon atoms, 5. ##STR13## wherein R'" is selected from the group consisting of --CONH 2 and --COA wherein A has the meaning given above,

Claim 18

--(CH 2 ) n --NH--R 1 , wherein n is 2 or 3 and R 1 is selected from the group consisting of hydrogen, --CONH 2 --COR 2 and --SO 2 R 3 wherein R 2 is selected from the group consisting of hydrogen, alkyl having 1-18 carbon atoms, alkenyl having 2 to 18 carbon atoms, --CF 3 , --CH 2 --C 6 H 5 , ##SPC10## wherein R 7 is selected from the group consisting of hydrogen, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms and halogen and R 3 is selected from the group consisting of alkyl having 1-4 carbon atoms and ##SPC11## wherein R 7 has the meaning given above, 7. --(CH 2 ) p --R 4 wherein p is 0, 1 or 2 and R 4 is selected from the group consisting of i. 1-naphthyl when p = 0 or 1, iii. 2-naphthyl when p = 0 or 1, iii. ##SPC12## when p = 0, 1 or 2, wherein q is 1, 2 or 3 and a' when q is 1, 2 or 3, R 5 is selected from the group consisting of hydrogen, halogen, alkoxy having 1-5 carbon atoms and alkyl having 1-4 carbon atoms and b'. when q is only 1, R 5 is selected from the group consisting of dialkylamino wherein the alkyl moiety has 1-3 carbon atoms, phenoxy, cyclohexyl, amino, phenyl, alkylthio wherein the alkyl moiety has 1-5 carbon atoms, alkylsulfinyl wherein the alkyl moiety has 1-5 carbon atoms and trifluoromethyl, 8. --CH 2 --CH 2 --CH 2 --C 6 H 5 , 9. --ch c 6 h 5 ) 2 ,

Claim 19

--(CH 2 ) n --NH--R 1 , wherein n is 2 or 3 and R 1 is selected from the group consisting of hydrogen, --CONH 2 --COR 2 and --SO 2 R 3 wherein R 2 is selected from the group consisting of hydrogen, alkyl having 1-18 carbon atoms, alkenyl having 2 to 18 carbon atoms, --CF 3 , --CH 2 --C 6 H 5 , ##SPC10## wherein R 7 is selected from the group consisting of hydrogen, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms and halogen and R 3 is selected from the group consisting of alkyl having 1-4 carbon atoms and ##SPC11## wherein R 7 has the meaning given above, 7. --(CH 2 ) p --R 4 wherein p is 0, 1 or 2 and R 4 is selected from the group consisting of i. 1-naphthyl when p = 0 or 1, iii. 2-naphthyl when p = 0 or 1, iii. ##SPC12## when p = 0, 1 or 2, wherein q is 1, 2 or 3 and a' when q is 1, 2 or 3, R 5 is selected from the group consisting of hydrogen, halogen, alkoxy having 1-5 carbon atoms and alkyl having 1-4 carbon atoms and b'. when q is only 1, R 5 is selected from the group consisting of dialkylamino wherein the alkyl moiety has 1-3 carbon atoms, phenoxy, cyclohexyl, amino, phenyl, alkylthio wherein the alkyl moiety has 1-5 carbon atoms, alkylsulfinyl wherein the alkyl moiety has 1-5 carbon atoms and trifluoromethyl, 8. --CH 2 --CH 2 --CH 2 --C 6 H 5 , 9. --ch c 6 h 5 ) 2 ,

Claim 20

--ch 2 --ch = ch -- c 6 h 5 , 11. --ch (c 6 h 4 p-OCH 3 ) 2 ,

Claim 21

--ch 2 --ch = ch -- c 6 h 5 , 11. --ch (c 6 h 4 p-OCH 3 ) 2 ,

Claim 22

--C (CH 3 ) 2 (C 6 H 4 p-OCH 3 ), 13. --(ch 2 ) s --COR 6 wherein s is an integer of 1-4 and R 6 is selected from the group consisting of OH, NH 2 , diethylamino and dimethylamino, and 14. 1,2-dicarboxyethyl b. when t =2, R is selected from the group consisting of 15. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3, 16. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3 and substituted by 1 or 2 OH functions, 17. butenylene, and 18. --(CH 2 ) 2 --SO 2 --(CH 2 ) 2 --, and (ii') the acid salts of the compound defined in (i').

Claim 23

--C (CH 3 ) 2 (C 6 H 4 p-OCH 3 ), 13. --(ch 2 ) s --COR 6 wherein s is an integer of 1-4 and R 6 is selected from the group consisting of OH, NH 2 , diethylamino and dimethylamino, and 14. 1,2-dicarboxyethyl b. when t =2, R is selected from the group consisting of 15. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3, 16. --(CH 2 ) n --CH 2 -- wherein n is 1, 2 or 3 and substituted by 1 or 2 OH functions, 17. butenylene, and 18. --(CH 2 ) 2 --SO 2 --(CH 2 ) 2 --, and (ii') the acid salts of the compound defined in (i').