US4761399A
Expired / Lapsed
US
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Dipeptide compounds having pharmaceutical activity and compositions containing them
Assignee: Zambon SpA
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Filing: 1985-10-16
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Granted: 1988-08-02
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Expires: 2005-10-16
Abstract
Abstract The compounds of formula ##STR1## wherein the group ##STR2## represents the residue of a natural amino acid selected from the group consisting of glycine, alanine, beta-alanine, phenylalanine, isoleucine, methionine, proline, aspartic acid and arginine; R represents a hydrogen atom or a C 1 -C 4 alkyl; and their acid-addition salts with pharmaceutically acceptable organic or inorganic acids; are useful in the preventive and curative treatment of pathologic syndromes due to the lowering of glutathione (GSH) levels.
Inventors
- 👤 Alberto Pilotto
- 👤 Mario Portelli
- 👤 Angelo Carenzi
- 👤 Davide Della Bella
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:05
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
57 words
A compound of formula ##STR15## wherein the group ##STR16## represents the residue of a natural amino acid selected from the group consisting of glycine, alanine, beta-alanine, phenylalanine, isoleucine, methionine, proline, aspartic acid and arginine; R represents a hydrogen atom or a C 1 -C 4 alkyl; and their acid-addition salts with pharmaceutically acceptable organic or inorganic acids.
Claim 2
Dependent Claim
57 words
A compound of formula ##STR15## wherein the group ##STR16## represents the residue of a natural amino acid selected from the group consisting of glycine, alanine, beta-alanine, phenylalanine, isoleucine, methionine, proline, aspartic acid and arginine; R represents a hydrogen atom or a C 1 -C 4 alkyl; and their acid-addition salts with pharmaceutically acceptable organic or inorganic acids.
Claim 3
Dependent Claim
16 words
A compound according to claim 1 in which R represents a C 1 -C 4 alkyl.
Claim 4
Dependent Claim
22 words
A pharmaceutically acceptable acid-addition salt of a compound according to claim 1 in which R represents a C 1 -C 4 alkyl.
Claim 5
Dependent Claim
24 words
A compound according to claim 1 in which the group ##STR17## represents the residue of an amino acid selected from methionine, beta-alanine and proline.
Claim 6
Dependent Claim
45 words
A method for the preventive and curative treatment of pathologic syndromes due to the depletion of the glutathione (GSH) content in the parenchymal organs and in the mesenchymal cellular population, said method consisting in administering a therapeutically effective amount of a compound of claim 1.
Claim 7
Dependent Claim
62 words
A method for the preventive or curative treatment of toxic or toxinfective hepatopathy, of respiratory affections having infective origin or originated by inhalation of extraneous substances, of arthritis, of degenerative cardiopathy during chemotherapy or of central or peripheral neuropathy due to depletion of glutathione (GSH) levels, said method consisting in administering a therapeutically effective amount of a compound according to claim 1.
Claim 8
Dependent Claim
47 words
A pharmaceutical composition for the preventive and curative treatment of pathologic syndromes due to the depletion of the glutathione (GSA) in the parenchymal organs and in the mesenchymal cellular population wherein said composite contains an effective amount of an active ingredient of the compound of claim 1.
Claim 9
Dependent Claim
60 words
A pharmaceutical composition for the preventive or curative treatment of toxic or toxinfective hepatopathy, of respiratory affections having an infective origin originating by inhalation of extraneous substances, arthritis, degenerative cardiopathy developed during chemotherapy or of central or peripheral neuropathy due to depletion of gluathione (GSH) levels containing an effective amount of an active ingredient of the compound of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-02 | 1992-02-01 | 1992-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-02 | 1996-02-01 | 1996-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-02 | 2000-02-01 | 2000-08-02 | $7700.00 | Window Closed / Lapsed |