US4710489A
Expired / Lapsed
US
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Glutathione delivery system
Assignee: Cornell Research Foundation Inc
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Filing: 1986-01-10
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Granted: 1987-12-01
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Expires: 2006-01-10
Abstract
Abstract Substantially pure alkyl monoesters of glutathione, the ester being of the glycine carboxylic acid, and use thereof to increase cellular levels of glutathione.
Inventors
- 👤 Alton Meister
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:23
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0215
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
56 words
A method for increasing cellular levels in animals of glutathione, comprising: administering a methyl and/or ethyl monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 2
Independent Claim
56 words
A method for increasing cellular levels in animals of glutathione, comprising: administering a methyl and/or ethyl monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said ester is the methyl ester.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said ester is the ethyl ester.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein said esterified glutathione is administered in a dosage of 0.5 to 10 millimoles per kilogram of animal body weight.
Claim 6
Dependent Claim
13 words
The method of claim 4 wherein said esterified glutathione is administered by injection.
Claim 7
Independent Claim
43 words
A method for detoxification of a drug in animals comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage to detoxify said animal of said drug.
Claim 8
Independent Claim
43 words
A method for detoxification of a drug in animals comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage to detoxify said animal of said drug.
Claim 9
Independent Claim
45 words
A method for increasing radiation resistance of an animal comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said animal.
Claim 10
Independent Claim
45 words
A method for increasing radiation resistance of an animal comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said animal.
Claim 11
Dependent Claim
10 words
The method of claim 6 wherein said drug is acetaminophen.
Claim 12
Independent Claim
58 words
A method for increasing the resistance of an animal to the effects of reactive oxygen intermediates comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal to the effects of reactive oxygen intermediates.
Claim 13
Independent Claim
58 words
A method for increasing the resistance of an animal to the effects of reactive oxygen intermediates comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal to the effects of reactive oxygen intermediates.
Claim 14
Independent Claim
60 words
A method for increasing cellular levels in animals of glutathione, comprising: administering an alkyl (C 3 to C 10 ) monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 15
Independent Claim
60 words
A method for increasing cellular levels in animals of glutathione, comprising: administering an alkyl (C 3 to C 10 ) monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 16
Dependent Claim
12 words
The method of claim 10 wherein said ester is a propyl ester.
Claim 17
Dependent Claim
12 words
The method of claim 10 wherein said ester is a butyl ester.
Claim 18
Dependent Claim
25 words
The method of claim 10 wherein said esterified glutathione is administered in a dosage of 0.5 to 10 millimoles per kilogram of animal body weight.
Claim 19
Dependent Claim
13 words
The method of claim 10 wherein said esterified glutathione is administered by injection.
Claim 20
Independent Claim
47 words
A method for detoxification of a drug in animals comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage to detoxify said animal of said drug.
Claim 21
Independent Claim
47 words
A method for detoxification of a drug in animals comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage to detoxify said animal of said drug.
Claim 22
Independent Claim
49 words
A method for increasing radiation resistance of an animal comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said animal.
Claim 23
Independent Claim
49 words
A method for increasing radiation resistance of an animal comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said animal.
Claim 24
Dependent Claim
10 words
The method of claim 15 wherein said drug is acetaminophen.
Claim 25
Independent Claim
61 words
A method for increasing the resistance of an animal to the effects of reactive oxygen intermediates comprising: administering a substantially pure (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal to the effects of reactive oxygen intermediates.
Claim 26
Independent Claim
61 words
A method for increasing the resistance of an animal to the effects of reactive oxygen intermediates comprising: administering a substantially pure (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal to the effects of reactive oxygen intermediates.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-30 | 1991-06-01 | 1991-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-30 | 1995-06-01 | 1995-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-30 | 1999-06-01 | 1999-12-01 | $7700.00 | Window Closed / Lapsed |