Patent US3916096A successfully refreshed from Google Patents.
US5236355A
Expired / Lapsed
US
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Apparatus for the treatment of periodontal disease
Assignee: Wyeth Holdings LLC
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Filing: 1990-10-05
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Granted: 1993-08-17
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Expires: 2010-10-05
Abstract
Abstract Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.
Inventors
- 👤 Nancy S. Brizzolara
- 👤 Michael G. Lanzilotti
- 👤 James R. Lawter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:46
CPC Classifications
A; A61; A61C; A61C19/00; A61C19/06; A61C19/063; A61K; A61K6/00; A61K6/15; A61K6/17; A61K6/30; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
171 words
An apparatus for dispensing an oral composition for alleviating dental diseases by local administration of a therapeutic agent to the periodontal pocket of a patient in need of such treatment, said apparatus comprising: (1) a container having barrel means ending in a hollow delivery tip outlet means adapted to fit the periodontal pocket between the patient's gum and teeth; (2) plunger means to translate an externally applied force onto dry therapeutic agent containing microparticles contained within the outlet means so as to dispense them through said outlet means tip into said periodontal pocket said plunger means comprising a rod with a solid tip which is partially inserted into said outlet means; and, in said outlet means, (3) said microparticles comprising: (i) an effective amount of at least one therapeutic agent dispersed in (ii) a matrix comprising a biocompatible and biodegradable polymer wherein the microparticles are made by a phase separation process using a volatile silicone fluid and have a residual volatile silicone fluid content of less than about 3% by weight.
Claim 2
Independent Claim
171 words
An apparatus for dispensing an oral composition for alleviating dental diseases by local administration of a therapeutic agent to the periodontal pocket of a patient in need of such treatment, said apparatus comprising: (1) a container having barrel means ending in a hollow delivery tip outlet means adapted to fit the periodontal pocket between the patient's gum and teeth; (2) plunger means to translate an externally applied force onto dry therapeutic agent containing microparticles contained within the outlet means so as to dispense them through said outlet means tip into said periodontal pocket said plunger means comprising a rod with a solid tip which is partially inserted into said outlet means; and, in said outlet means, (3) said microparticles comprising: (i) an effective amount of at least one therapeutic agent dispersed in (ii) a matrix comprising a biocompatible and biodegradable polymer wherein the microparticles are made by a phase separation process using a volatile silicone fluid and have a residual volatile silicone fluid content of less than about 3% by weight.
Claim 3
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein the therapeutic agent is an antibiotic.
Claim 4
Dependent Claim
12 words
An apparatus as defined in claim 2 wherein the antibiotic is minocycline.
Claim 5
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein the volatile silicone fluid is decamethylcyclopentasiloxane.
Claim 6
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein the volatile silicone fluid is octamethylcyclotetrasiloxane.
Claim 7
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein the volatile silicone fluid is hexamethyldisiloxane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-16 | 1997-02-15 | 1997-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-16 | 2001-02-15 | 2001-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-16 | 2005-02-15 | 2005-08-17 | $7700.00 | Window Closed / Lapsed |