US5230900A
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US
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Antibody-mediated and ligand-mediated targeting of differentiation-inducers to tumor cells
Assignee: Biomembrane Institute
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Filing: 1991-07-12
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Granted: 1993-07-27
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Expires: 2011-07-12
Abstract
Abstract The present invention relates to compositions which mediate antibody and ligand targeting of differentiation-inducers to tumor cells and methods for employing the same.
Inventors
- 👤 Sen-itiroh Hakomori
- 👤 Michiro Otaka
- 👤 Anil Singhal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/167; A61K47/00; A61K47/50; A61K47/51; A61K9/10; A61K9/127; A61K9/1271; Y; Y10; Y10S; Y10S424/00; Y10S424/812; Y10S436/00; Y10S436/829
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
88 words
A method for treating a tumor comprising administering to a subject afflicted with said tumor, a differentiation inducing effective amount of a composition comprising an antibody directed to said tumor, wherein said antibody is conjugated to a ganglioside liposome comprising a phospholipid, or a non-antibody ligand directed to said tumor, wherein said ligand is conjugated to a ganglioside liposome comprising a phospholipid, wherein said ganglioside liposome contains in the core thereof a differentiation-inducer selected from the group consisting of n-butyric acid or a salt thereof and retinoic acid.
Claim 2
Independent Claim
88 words
A method for treating a tumor comprising administering to a subject afflicted with said tumor, a differentiation inducing effective amount of a composition comprising an antibody directed to said tumor, wherein said antibody is conjugated to a ganglioside liposome comprising a phospholipid, or a non-antibody ligand directed to said tumor, wherein said ligand is conjugated to a ganglioside liposome comprising a phospholipid, wherein said ganglioside liposome contains in the core thereof a differentiation-inducer selected from the group consisting of n-butyric acid or a salt thereof and retinoic acid.
Claim 3
Dependent Claim
38 words
The method as claimed in claim 1, wherein said ganglioside liposome comprises as a main component, a phospholipid selected from at least one member of the group consisting of dipalmitoyl phosphatidylcholine, distearyl phosphatidyl choline, sphingomyelin and phosphatidyl ethanolamine.
Claim 4
Dependent Claim
74 words
The method as claimed in claim 1, wherein said ganglioside in said ganglioside liposome is selected from at least one member of the group consisting of a polysialyl ganglioside selected from at least one member of the group consisting of GT 1b , GT 1a and GQ 1 and a high density monosialyl ganglioside selected from at least one member of the group consisting of GM 3 , GM 1a and LM 1 .
Claim 5
Dependent Claim
21 words
The method as claimed in claim 1, wherein said pharmaceutically effective amount is about 0.3 to 1.0 mg/kg of body weight.
Claim 6
Dependent Claim
21 words
The method as claimed in claim 4, wherein said pharmaceutically effective amount is about 0.5 to 1.0 mg/kg of body weight.
Claim 7
Dependent Claim
27 words
The method as claimed in claim 1, wherein said antibody directed to a tumor or said ligand directed to a tumor is administered intravenously, intraperitoneally or intra-arterially.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-26 | 1997-01-25 | 1997-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-26 | 2001-01-25 | 2001-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-26 | 2005-01-25 | 2005-07-27 | $7700.00 | Window Closed / Lapsed |