US4501728A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Masking of liposomes from RES recognition
Assignee: Calfee Halter and Griswold LLP
•
Filing: 1983-01-06
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Granted: 1985-02-26
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Expires: 2003-01-06
Abstract
Abstract A biochemical membrane covered with sialic residues thereby provides a coating that masks the surface membrane from recognition and removal by the scavenging RES cells of the body.
Inventors
- 👤 W. Blair Geho
- 👤 John R. Lau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:15
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1812; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
49 words
A delivery system consisting essentially of a biochemical membrane containing a drug, hormone, diagnostic or nutritional material covered with sialic acid residues such that the membrane is shielded from the RES thereby providing a coating that masks the surface membrane from recognition by the scavenging cells of the body.
Claim 2
Dependent Claim
49 words
A delivery system consisting essentially of a biochemical membrane containing a drug, hormone, diagnostic or nutritional material covered with sialic acid residues such that the membrane is shielded from the RES thereby providing a coating that masks the surface membrane from recognition by the scavenging cells of the body.
Claim 3
Dependent Claim
16 words
The surface of the membrane in claim 1 which has an amphiphilic coating including N-acetylneuraminic acid.
Claim 4
Dependent Claim
58 words
A liposome having a core with at least one entrapped drug, hormone, diagnostic or nutritional material and the surface thereof masked from recognition by the reticuloendothelial system of the living body by having embedded in said surface the lipophilic portion of an amphiphilic coating which includes N-acetylneuraminic acid, the hydrophilic portion extending therefrom and substantially coating the surface.
Claim 5
Dependent Claim
58 words
A liposome having a core with at least one entrapped drug, hormone, diagnostic or nutritional material and the surface thereof masked from recognition by the reticuloendothelial system of the living body by having embedded in said surface the lipophilic portion of an amphiphilic coating which includes N-acetylneuraminic acid, the hydrophilic portion extending therefrom and substantially coating the surface.
Claim 6
Independent Claim
49 words
The method of making a liposome carrier of drug, hormone, diagnostic or nutritional material masked from recognition by the scavenging cells of a living animal comprising the provision of an amphiphilic coating which includes N-acetylneuraminic acid and incorporating such coating into the manufacture of a liposome by known techniques.
Claim 7
Independent Claim
49 words
The method of making a liposome carrier of drug, hormone, diagnostic or nutritional material masked from recognition by the scavenging cells of a living animal comprising the provision of an amphiphilic coating which includes N-acetylneuraminic acid and incorporating such coating into the manufacture of a liposome by known techniques.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-26 | 1988-08-27 | 1989-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-26 | 1992-08-27 | 1993-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-26 | 1996-08-27 | 1997-02-26 | $7700.00 | Window Closed / Lapsed |