Method of performing multiple synthesis of peptides on solid carrier

Claim 1

A method of synthesizing peptides, comprising the steps of: providing a planar carrier on a disk, which carrier is divided into a plurality of individual compartments, each compartment containing an inert porous material, a circular path being defined around said disk, said compartments being circumferentially spaced along said circular path; anchoring at least one functional group for synthesis of at least one peptide onto the inert porous material of each compartment to form a plurality of individual functionalized compartments; arranging a dosing head at a fixed location adjacent said circular path, the dosing head including means for directly applying measured quantities of at least one liquid component from a common reservoir of such component; positioning the disk so that one of the individual functionalized compartments is positioned to receive a liquid component directly applied by the closing head; directly applying a measured quantity of a liquid component to an individual functionalized compartment from the common reservoir thereof, via the dosing head, the applied component providing an amino acid to form a covalent bond with the functional group of the individual functionalized compartment positioned to receive the liquid component for beginning the synthesis of a peptide from the functional group of the individual functionalized compartment receiving the measured quantity; rotating the disk to position another individual compartment along the circular path to receive a liquid component applied by the dosing head; and subsequently applying at least one other amino acid to another individual functionalized compartment in at least one other step for completing the synthesis of peptides.

Claim 2

A method of synthesizing peptides, comprising the steps of: providing a planar carrier on a disk, which carrier is divided into a plurality of individual compartments, each compartment containing an inert porous material, a circular path being defined around said disk, said compartments being circumferentially spaced along said circular path; anchoring at least one functional group for synthesis of at least one peptide onto the inert porous material of each compartment to form a plurality of individual functionalized compartments; arranging a dosing head at a fixed location adjacent said circular path, the dosing head including means for directly applying measured quantities of at least one liquid component from a common reservoir of such component; positioning the disk so that one of the individual functionalized compartments is positioned to receive a liquid component directly applied by the closing head; directly applying a measured quantity of a liquid component to an individual functionalized compartment from the common reservoir thereof, via the dosing head, the applied component providing an amino acid to form a covalent bond with the functional group of the individual functionalized compartment positioned to receive the liquid component for beginning the synthesis of a peptide from the functional group of the individual functionalized compartment receiving the measured quantity; rotating the disk to position another individual compartment along the circular path to receive a liquid component applied by the dosing head; and subsequently applying at least one other amino acid to another individual functionalized compartment in at least one other step for completing the synthesis of peptides.