Medicaments

Claim 1

A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of a compound of formula (VIII): ##STR12## wherein: L is NH or O; R 29 and R 30 are independently selected from hydrogen, halogen, CF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-7 acyl, C 1-7 acylamino, C 1-6 alkylsulphonylamino, N-(C 1-6 alkylsulphonyl)-N-(C 1-4 alkylamino, C 1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C 1-4 alkylamino optionally N-substituted by one or two groups selected from C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-4 alkyl, phenyl or phenylC 1-4 alkyl groups or optionally N-disubstituted by C 4-5 polymethylene; D and E are independently selected from hydrogen or C 1-4 alkyl, or together are a bond; R 31 and R 32 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenylC 1-4 alkyl, or together are C 2-4 polymethylene; M is a group of formula (a), (b) or (c): ##STR13## wherein t is 2 or 3; u is 1 or 2; v is 1 to 3; w is 1 to 3; and R 33 or R 34 is C 1-7 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-2 alkyl or C 2-7 alkenylC 1-4 alkenyl; or a pharmaceutically acceptable salt thereof.

Claim 2

A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of a compound of formula (VIII): ##STR12## wherein: L is NH or O; R 29 and R 30 are independently selected from hydrogen, halogen, CF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-7 acyl, C 1-7 acylamino, C 1-6 alkylsulphonylamino, N-(C 1-6 alkylsulphonyl)-N-(C 1-4 alkylamino, C 1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C 1-4 alkylamino optionally N-substituted by one or two groups selected from C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-4 alkyl, phenyl or phenylC 1-4 alkyl groups or optionally N-disubstituted by C 4-5 polymethylene; D and E are independently selected from hydrogen or C 1-4 alkyl, or together are a bond; R 31 and R 32 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenylC 1-4 alkyl, or together are C 2-4 polymethylene; M is a group of formula (a), (b) or (c): ##STR13## wherein t is 2 or 3; u is 1 or 2; v is 1 to 3; w is 1 to 3; and R 33 or R 34 is C 1-7 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-2 alkyl or C 2-7 alkenylC 1-4 alkenyl; or a pharmaceutically acceptable salt thereof.

Claim 3

A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-3,3-dimethylindole-1-carboxamide or a pharmaceutically acceptable salt thereof.

Claim 4

A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-3,3-dimethylindole-1-carboxamide or a pharmaceutically acceptable salt thereof.