US4883803A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of anxiety
Assignee: Glaxo Group Ltd
•
Filing: 1988-10-19
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Granted: 1989-11-28
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Expires: 2008-10-19
Abstract
Abstract The invention relates to the use of compounds which act as 5-hydroxytryptamine (5-HT) antagonists at 5-HT "M" receptors in the treament of anxiety.
Inventors
- 👤 Michael B. Tyers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/46; A61K31/40; A61K31/44; A61K31/445; A61K31/55; A61P; A61P25/00; A61P25/20; A61P43/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
133 words
A method for the treatment of anxiety in a human or animal subject suffering from or susceptible to anxiety which comprises administering to the human or animal subject an effective amount for the treatment of anxiety in said subject of a compound of formula (II) ##STR6## wherein R 1 and R 2 independently represent hydrogen, halogen, C 1-4 alkoxy, hydroxy, amino, C 1-4 alkylamino, di(C 1-4 )alkylamino, mercapto or C 1-4 alkylthio; R 3 represents hydrogen, C 1-4 alkyl, C 3-5 alkenyl, aryl or aralkyl; R 4 represents hydrogen, C 1-7 alkyl, C 3-5 alkenyl or aralkyl; n is 2 or 3; the free valence is attached to either fused ring and the azabicyclic ring is in either the exo or endo configuration; or an acid addition salt or quaternary ammonium salt thereof.
Claim 2
Independent Claim
133 words
A method for the treatment of anxiety in a human or animal subject suffering from or susceptible to anxiety which comprises administering to the human or animal subject an effective amount for the treatment of anxiety in said subject of a compound of formula (II) ##STR6## wherein R 1 and R 2 independently represent hydrogen, halogen, C 1-4 alkoxy, hydroxy, amino, C 1-4 alkylamino, di(C 1-4 )alkylamino, mercapto or C 1-4 alkylthio; R 3 represents hydrogen, C 1-4 alkyl, C 3-5 alkenyl, aryl or aralkyl; R 4 represents hydrogen, C 1-7 alkyl, C 3-5 alkenyl or aralkyl; n is 2 or 3; the free valence is attached to either fused ring and the azabicyclic ring is in either the exo or endo configuration; or an acid addition salt or quaternary ammonium salt thereof.
Claim 3
Dependent Claim
55 words
A method according to claim 1 wherein R 1 and R 2 independently represent hydrogen or halogen, R 3 is hydrogen or C 1-4 alkyl, R 4 is hydrogen, C 1-7 alkyl or aralkyl, the carbonyl group is attached to the 3-position of the indole ring and the azabicyclic ring is in the endo configuration.
Claim 4
Dependent Claim
16 words
A method according to claim 1 wherein the compound of formula (II) is (3α-tropanyl)-1H-indole-3-carboxylic acid ester.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-27 | 2001-05-29 | 2001-11-28 | $7700.00 | Window Closed / Lapsed |