US4985437A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicaments
Assignee: Glaxo Group Ltd
•
Filing: 1987-12-16
•
Granted: 1991-01-15
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Expires: 2007-12-16
Abstract
Abstract The invention relates to the use of certain compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT 3 receptors for the treatment of cognitive disorders such as attentional and memory deficits and dementia states.
Inventors
- 👤 Michael B. Tyers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K31/41; A61K31/415; A61K31/435; A61K31/44; A61K31/445; A61K31/46; A61K31/495; A61K31/50; A61P; A61P25/00; A61P25/28; A61P43/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
197 words
A method for the treatment of dementia and other cognitive disorders which comprises administering to a human or animal subject suffering from dementia or another cognitive disorder an effective amount for the treatment of said dementia or other cognitive disorder of a compound of formula I TABLE I
______________________________________
Design Parameters for a Narrow-Band Optical Interference Filter
of the 1.0 HL HH LHLHL HH L'H 1.0 Type
Optical Thin Film Filter
(Pass Wavelength = 1.00 um)
Refractive
Thickness
Index (A)
______________________________________
Input Region 1.00 . . .
Region 1 (H) 4.00 625.000
Region 2 (L) 1.35 1851.852
Region 3 (L') 1.83 1366.120
Output Region 1.00 . . .
______________________________________ wherein R 1 and R 2 independently represent hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, amino, C 1-4 alkylamino, di(C 1-4 )alkylamino, mercapto or C 1-4 alkylthio; R 3 represents hydrogen, C 1-4 alkyl, C 3-5 alkenyl, aryl or aralkyl; R 4 represents hydrogen, C 1-7 alkyl, C 3-5 alkenyl or aralkyl; n is 2 or 3; the free valence is attached to either fused ring, and the azabicyclic ring is in either the exo or endo configuration; or a physiologically acceptable salt or solvate thereof.
Claim 2
Independent Claim
197 words
A method for the treatment of dementia and other cognitive disorders which comprises administering to a human or animal subject suffering from dementia or another cognitive disorder an effective amount for the treatment of said dementia or other cognitive disorder of a compound of formula I TABLE I
______________________________________
Design Parameters for a Narrow-Band Optical Interference Filter
of the 1.0 HL HH LHLHL HH L'H 1.0 Type
Optical Thin Film Filter
(Pass Wavelength = 1.00 um)
Refractive
Thickness
Index (A)
______________________________________
Input Region 1.00 . . .
Region 1 (H) 4.00 625.000
Region 2 (L) 1.35 1851.852
Region 3 (L') 1.83 1366.120
Output Region 1.00 . . .
______________________________________ wherein R 1 and R 2 independently represent hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, amino, C 1-4 alkylamino, di(C 1-4 )alkylamino, mercapto or C 1-4 alkylthio; R 3 represents hydrogen, C 1-4 alkyl, C 3-5 alkenyl, aryl or aralkyl; R 4 represents hydrogen, C 1-7 alkyl, C 3-5 alkenyl or aralkyl; n is 2 or 3; the free valence is attached to either fused ring, and the azabicyclic ring is in either the exo or endo configuration; or a physiologically acceptable salt or solvate thereof.
Claim 3
Dependent Claim
58 words
A method according to claim 1 wherein R 1 and R 2 independently represent hydrogen, halogen or C 1-4 alkyl; R 3 represents hydrogen or C 1-4 alkyl; R 4 represents hydrogen, C 1-7 alkyl or aralkyl; the carbonyl group is attached to the 3-position of the indole ring, and the azabicyclic ring is in the endo configuration.
Claim 4
Dependent Claim
33 words
A method according to claim 1 wherein said compound selected from compounds of formula (I) is administered in a dose of 0.5 μg to 20 mg from 1 to 4 times per day.
Claim 5
Dependent Claim
33 words
A method according to claim 1 wherein said compound selected from compounds of formula (I) is administered in a dose of 0.05 mg to 10 mg from 1 to 4 times per day.
Claim 6
Independent Claim
52 words
A method for the treatment of dementia and other cognitive disorders which comprises administering to a human or animal subject suffering from dementia or another cognitive disorder an effective amount for the treatment of said dementia or other cognitive disorder of -(3α-tropanyl)-1H-indole-3-carboxylic acid ester or a physiologically acceptable salt or solvate thereof.
Claim 7
Independent Claim
52 words
A method for the treatment of dementia and other cognitive disorders which comprises administering to a human or animal subject suffering from dementia or another cognitive disorder an effective amount for the treatment of said dementia or other cognitive disorder of -(3α-tropanyl)-1H-indole-3-carboxylic acid ester or a physiologically acceptable salt or solvate thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-14 | 1994-07-16 | 1995-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-14 | 1998-07-16 | 1999-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-14 | 2002-07-16 | 2003-01-15 | $7700.00 | Window Closed / Lapsed |