US4847281A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of medical treatment of addiction
Assignee: Glaxo Group Ltd
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Filing: 1987-11-20
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Granted: 1989-07-11
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Expires: 2007-11-20
Abstract
Abstract The invention relates to the use of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H</ U>-carbazol-4-one and physiologically acceptable salts and solvates thereof in the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or susbtances of abuse.
Inventors
- 👤 Michael B. Tyers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:21
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/435; A61K31/46; A61P; A61P39/00; A61P39/02
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
76 words
A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance or abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of 1,2,3,9-tetrahydro-9-methyl-3-[2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a physiologically acceptable salt or solvate thereof.
Claim 2
Independent Claim
76 words
A method of treatment for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance or abuse and/or for the suppression of dependence on drugs or substances of abuse, which comprises administering to a human or animal subject suffering from or liable to suffer from said withdrawal syndrome and/or dependent on a drug or substance of abuse an effective amount of 1,2,3,9-tetrahydro-9-methyl-3-[2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a physiologically acceptable salt or solvate thereof.
Claim 3
Dependent Claim
19 words
A method according to claim 1 wherein said 1,2,3,9-tetrahydro-9-methyl-3-[m2-ethyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one is administered in the form of the hydrochloride dihydrate salt.
Claim 4
Dependent Claim
44 words
A method according to claim 1 wherein said 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a physiologically acceptable salt or solvate thereof is administered in a dose of 0.05 to 20 mg from 1 to 4 times per day, the dose being expressed as the weight of free base.
Claim 5
Dependent Claim
22 words
A method according to claim 3 wherein said dose is from 0.1 to 10 mg from 1 to 4 times per day.
Claim 6
Dependent Claim
16 words
A method according to claim 1 wherein said drug or substance of abuse is an opiate.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein said drug or substance of abuse is cocaine.
Claim 8
Dependent Claim
16 words
A method according to claim 1 wherein said drug or substance of abuse is a benzodiazepine.
Claim 9
Dependent Claim
15 words
A method according to claim 1 wherein said drug or substance of abuse is alcohol.
Claim 10
Dependent Claim
15 words
A method according to claim 1 wherein said drug or substance of abuse is nicotine.
Claim 11
Dependent Claim
20 words
A method according to claim 1 wherein said 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one is administered orally, buccally, parenterally, rectally, or as a depot preparation.
Claim 12
Dependent Claim
17 words
A method according to claim 1 wherein said 1,2,3,9-tetrahydro-9-methyl-3-[2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one is administered in the form of a hydrochloride.
References Cited (Backward Citations)
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GB2153821A
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US4721720A
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US4721720B1
Cited
US4753789A
Cited
GB2193633A
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EP0272052A1
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GB2206788A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |