Patent US5161532A successfully refreshed from Google Patents.
US5161532A
Expired / Lapsed
US
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Integral interstitial fluid sensor
Assignee: SRI International Inc
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Filing: 1990-04-19
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Granted: 1992-11-10
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Expires: 2010-04-19
Abstract
Abstract An integral interstitial fluid sensor for application to the skin of a person or an animal for the detection of chemical components of tissue fluid is disclosed. The fluid sensor comprises a substrate of a porous material for the passage of the interstitial fluid therethrough. At least two electrodes are provided. One of the electrodes has two sides, with one side mounted on the substrate. The electrode is also of a porous material and permits the passage of the interstitial fluid from one side through to the second side which is generally opposite the one side. A layer of chemical is on the second side. The layer of chemical comprises a chemical for reaction with one component of the fluid, mixed in a mediating agent. The electrodes generate an electrical signal upon the detection of the reaction of the one component of the fluid with the chemical. The electrical signal is received by a detector and a display is generated, indicating the amount of the one component detected. Finally, a pump for sucking the fluid from the skin into the sensor is disclosed.
Inventors
- 👤 Jose P. Joseph
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:58
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/44; A61B5/441; A61B10/00; A61B10/0045; A61B2010/008
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
199 words
An integral interstitial fluid sensor for application to the skin of a person or an animal for detection of chemical components of an interstitial fluid, said sensor, comprising: a substrate of a porous material for passage of the interstitial fluid therethrough; at least two electrodes: a first electrode and a second electrode; said first electrode has two sides: a first side and a second side, said first side is mounted on said substrate with said second side generally opposite said first side, said first electrode is of a porous material for passage of the interstitial fluid through the two sides; a layer of chemical in contact with said second side of said first electrode for reaction with one component of said interstitial fluid, mixed in a mediating agent; said second electrode in contact with said layer of chemical; said two electrodes for generating an electrical signal in response to the reaction of the one component of said interstitial fluid with said layer of chemical; detecting means for receiving said electrical signal; means for generating a display in response to said detecting means; and means for sucking said fluid from the skin through said substrate into said layer of chemical.
Claim 2
Dependent Claim
199 words
An integral interstitial fluid sensor for application to the skin of a person or an animal for detection of chemical components of an interstitial fluid, said sensor, comprising: a substrate of a porous material for passage of the interstitial fluid therethrough; at least two electrodes: a first electrode and a second electrode; said first electrode has two sides: a first side and a second side, said first side is mounted on said substrate with said second side generally opposite said first side, said first electrode is of a porous material for passage of the interstitial fluid through the two sides; a layer of chemical in contact with said second side of said first electrode for reaction with one component of said interstitial fluid, mixed in a mediating agent; said second electrode in contact with said layer of chemical; said two electrodes for generating an electrical signal in response to the reaction of the one component of said interstitial fluid with said layer of chemical; detecting means for receiving said electrical signal; means for generating a display in response to said detecting means; and means for sucking said fluid from the skin through said substrate into said layer of chemical.
Claim 3
Dependent Claim
60 words
The sensor of claim 1 wherein said second electrode is mounted on said substrate, said second electrode has two sides with one side on said substrate and the other side generally opposite thereto, for the passage of the interstitial fluid through said two sides, and with said layer of chemical in contact with said other side of said second electrode.
Claim 4
Dependent Claim
45 words
The sensor of claim 1 wherein said second electrode has two sides with one side in contact with said layer of chemical, and the other side, generally opposite said one side, said second electrode for the passage of the interstitial fluid through the two sides.
Claim 5
Dependent Claim
10 words
The sensor of claim 1 wherein said substrate is ceramic.
Claim 6
Dependent Claim
16 words
The sensor of claim 1 wherein said first electrode comprises Pt mounted on said porous substrate.
Claim 7
Dependent Claim
16 words
The sensor of claim 5 wherein said second electrode is AgCl mounted on said porous substrate.
Claim 8
Dependent Claim
19 words
The sensor of claim 1 wherein said layer of chemical is glucose oxidase and said one component is glucose.
References Cited (Backward Citations)
GB1394171A
Cited
US4294258A
Cited
FR2426904A1
Cited
US4240438A
Cited
US4450842A
Cited
US4432366A
Cited
US4534356A
Cited
US4655880A
Cited
US4781798A
Cited
DE3713060A1
Cited
US4919141A
Cited
US4750496A
Cited
GB2204408A
Cited
US4975175A
Cited
US4832034A
Cited
US4953552A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |