Spray gel base and spray gel preparation using thereof

Claim 1

A gel preparation for spray into a nasal cavity comprising an aqueous gel of a carboxyvinyl polymer having a viscosity of 500-5,000 centipoise and pH 4-9, which is prepared by thickening a 0.2-1.5% by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonia, alkylamines, dialkylamines, trialkylamines, alkanolamines, dialkanolamines, trialkanolamines, and amino acids in an amount which is necessary for neutralization to adjust the pH value of the aqueous solution of carboxyvinyl polymer to pH 4-9, followed by adjusting the viscosity within the range of 500-5,000 centipoise, and an effective amount of an influenza vaccine selected from the group consisting of virus particle vaccine, HA vaccine, live virus vaccine, artificial membrane vaccine, genetic manipulated vaccine and peptide vaccine.

Claim 3

A method of delivering a medicament by spraying into the nasal cavity which comprises: adding an effective amount of an influenza vaccine selected from the group consisting of virus particle vaccine, HA vaccine, live virus vaccine, artificial membrane vaccine, genetic manipulated vaccine and peptide vaccine to a gel base for spray to form a gel preparation, wherein said gel base comprises an aqueous gel of a carboxyvinyl polymer having a viscosity of 500-5,000 centipoise and pH 4-9, which is prepared by thickening a 0.2-1.5% by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonia, alkylamines, dialkylamines, trialkylamines, alkanolamines, dialkanolamines, trialkanolamines, and amino acids in an amount which is necessary for neutralization to adjust the pH value of the aqueous solution of carboxyvinyl polymer to pH 4-9, followed by adjusting the viscosity thereof with a viscosity adjustor selected from the group consisting of sodium chloride, potassium chloride and calcium chlorine in an amount which is necessary for adjusting the viscosity within the range of 500-5,000 centipoise, and administering said gel preparation to a subject in need an effective amount of an influenza vaccine selected from the thereof by spraying into a nasal cavity.

Claim 4

A method of delivering a medicament by spraying into the nasal cavity which comprises: adding an effective amount of an influenza vaccine selected from the group consisting of virus particle vaccine, HA vaccine, live virus vaccine, artificial membrane vaccine, genetic manipulated vaccine and peptide vaccine to a gel base for spray to form a gel preparation, wherein said gel base comprises an aqueous gel of a carboxyvinyl polymer having a viscosity of 500-5,000 centipoise and pH 4-9, which is prepared by thickening a 0.2-1.5% by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonia, alkylamines, dialkylamines, trialkylamines, alkanolamines, dialkanolamines, trialkanolamines, and amino acids in an amount which is necessary for neutralization to adjust the pH value of the aqueous solution of carboxyvinyl polymer to pH 4-9, followed by adjusting the viscosity thereof with a viscosity adjustor selected from the group consisting of sodium chloride, potassium chloride and calcium chlorine in an amount which is necessary for adjusting the viscosity within the range of 500-5,000 centipoise, and administering said gel preparation to a subject in need an effective amount of an influenza vaccine selected from the thereof by spraying into a nasal cavity.