US4267169A
Expired / Lapsed
US
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Novel preparation of clotrimazole
Assignee: Toko Yakuhin Kogyo KK
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Filing: 1979-07-12
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Granted: 1981-05-12
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Expires: 1999-07-12
Abstract
Abstract A new type of preparation of clotrimazole, such as gel preparation, creamy preparation and liquid preparation, which are useful for an external use for the treatment of various trichophytoses, wherein the active clotrimazole is contained as being dissolved in crotamiton. Said new type of preparation of clotrimazole can be applied to the skin without drawbacks such as skin irritation and soiling of clothes as seen in the conventional tincture or ointments.
Inventors
- 👤 Takuzo Kamishita
- 👤 Kazuhiko Kamishita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K47/00; A61K47/06; A61K47/16; A61K47/18
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
59 words
A preparation useful for external treatment of trichophytoses, which comprises a solution of clotrimazole in crotamiton in admixture with a carrier or diluent, wherein said clotrimazole is contained in an amount of 0.5 to 2% by weight and said crotamiton is contained in an amount of 2 to 10% by weight, based upon the total weight of the preparation.
Claim 2
Dependent Claim
59 words
A preparation useful for external treatment of trichophytoses, which comprises a solution of clotrimazole in crotamiton in admixture with a carrier or diluent, wherein said clotrimazole is contained in an amount of 0.5 to 2% by weight and said crotamiton is contained in an amount of 2 to 10% by weight, based upon the total weight of the preparation.
Claim 3
Dependent Claim
83 words
A gel preparation useful for external treatment of trichophytoses, which comprises 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 70% by weight of ethanol or ethanol containing less than 40% by weight of propylene glycol, 0.1 to 3.0% by weight of carboxyvinyl polymer, and remainder of water, said preparation having been neutralized with a basic substance and having a pH of 4 to 10 and a viscosity of 2,000 to 100,000 cps at 20° C.
Claim 4
Dependent Claim
83 words
A gel preparation useful for external treatment of trichophytoses, which comprises 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 70% by weight of ethanol or ethanol containing less than 40% by weight of propylene glycol, 0.1 to 3.0% by weight of carboxyvinyl polymer, and remainder of water, said preparation having been neutralized with a basic substance and having a pH of 4 to 10 and a viscosity of 2,000 to 100,000 cps at 20° C.
Claim 5
Dependent Claim
22 words
A gel preparation according to claim 2, wherein the carboxyvinyl polymer is contained in an amount of 0.5 to 1.2% by weight.
Claim 6
Dependent Claim
83 words
A creamy preparation useful for external treatment of trichophytoses, which comprises 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 10 to 50% by weight of an oily substance, 0.5 to 5.0% by weight of a nonionic surfactant, 0.1 to 3.0% by weight of a carboxyvinyl polymer, and remainder of water, said preparation having been neutralized with basic substance and having a pH of 4 to 10 and a viscosity of 10,000 to 100,000 cps at 20° C.
Claim 7
Dependent Claim
83 words
A creamy preparation useful for external treatment of trichophytoses, which comprises 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 10 to 50% by weight of an oily substance, 0.5 to 5.0% by weight of a nonionic surfactant, 0.1 to 3.0% by weight of a carboxyvinyl polymer, and remainder of water, said preparation having been neutralized with basic substance and having a pH of 4 to 10 and a viscosity of 10,000 to 100,000 cps at 20° C.
Claim 8
Dependent Claim
22 words
A creamy preparation according to claim 4, wherein the carboxyvinyl polymer is contained in an amount of 0.5 to 1.2% by weight.
Claim 9
Dependent Claim
75 words
A creamy preparation according to claim 4, wherein the oily substance is a member selected from the group consisting of a fatty alcohol having 8 to 18 carbon atoms, a fatty acid having 8 to 18 carbon atoms, an alkyl ester of a fatty acid wherein the alkyl moiety has 1 to 18 carbon atoms and the fatty acid has 8 to 18 carbon atoms, a liquid or solid hydrocarbon, and a fat and oil.
Claim 10
Dependent Claim
29 words
A creamy preparation according to claim 4, wherein propylene glycol is incorporated in an amount of less than 40% by weight based upon the total weight of the preparation.
Claim 11
Dependent Claim
47 words
A liquid preparation useful for external treatment of trichophytoses which comprises 0.5 to 2% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 60% by weight of ethanol or ethanol containing less than 40% by weight of propylene glycol, and remainder of water.
Claim 12
Dependent Claim
47 words
A liquid preparation useful for external treatment of trichophytoses which comprises 0.5 to 2% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 60% by weight of ethanol or ethanol containing less than 40% by weight of propylene glycol, and remainder of water.
Claim 13
Dependent Claim
20 words
A pharmaceutical composition containing a solution of clotrimazole in crotamiton in an amount effective for the external treatment of trichophytoses.
Claim 14
Dependent Claim
20 words
A pharmaceutical composition containing a solution of clotrimazole in crotamiton in an amount effective for the external treatment of trichophytoses.
Claim 15
Dependent Claim
20 words
The composition of claim 1 in the form of a gel, a creamy preparation or an aqueous solution containing ethanol.
Claim 16
Dependent Claim
119 words
A process for preparing a transparent gel preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto ethanol or ethanol containing less than 40% by weight of propylene glycol and an aqueous solution of a carboxyvinyl polymer, and then neutralizing the mixture with a basic substance to a pH of 4 to 10, said gel preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 70% by weight of ethanol or propylene glycol-containing ethanol, 0.1 to 3.0% by weight of the carboxyvinyl polymer, and remainder of water, and having a pH of 4 to 10 and a viscosity of 2,000 to 100,000 cps at 20° C.
Claim 17
Dependent Claim
119 words
A process for preparing a transparent gel preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto ethanol or ethanol containing less than 40% by weight of propylene glycol and an aqueous solution of a carboxyvinyl polymer, and then neutralizing the mixture with a basic substance to a pH of 4 to 10, said gel preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 70% by weight of ethanol or propylene glycol-containing ethanol, 0.1 to 3.0% by weight of the carboxyvinyl polymer, and remainder of water, and having a pH of 4 to 10 and a viscosity of 2,000 to 100,000 cps at 20° C.
Claim 18
Dependent Claim
118 words
A process for preparing a creamy preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto an oily substance, a nonionic surfactant and an aqueous solution of a carboxyvinyl polymer, and neutralizing the mixture with a basic substance to a pH of 4 to 10, said creamy preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 10 to 50% by weight of the oily substance, 0.5 to 5.0% by weight of the nonionic surfactant, 0.1 to 3.0% by weight of the carboxyvinyl polymer and remainder of water, and having a pH of 4 to 10 and a viscosity of 10,000 to 100,000 cps at 20° C.
Claim 19
Dependent Claim
118 words
A process for preparing a creamy preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto an oily substance, a nonionic surfactant and an aqueous solution of a carboxyvinyl polymer, and neutralizing the mixture with a basic substance to a pH of 4 to 10, said creamy preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 10 to 50% by weight of the oily substance, 0.5 to 5.0% by weight of the nonionic surfactant, 0.1 to 3.0% by weight of the carboxyvinyl polymer and remainder of water, and having a pH of 4 to 10 and a viscosity of 10,000 to 100,000 cps at 20° C.
Claim 20
Dependent Claim
68 words
A process for preparing a liquid preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto ethanol or ethanol containing less than 40% by weight of propylene glycol and water, said liquid preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 60% by weight of ethanol or propylene glycol-containing ethanol, and remainder of water.
Claim 21
Dependent Claim
68 words
A process for preparing a liquid preparation useful for external treatment of trichophytoses, which comprises dissolving clotrimazole in crotamiton, adding thereto ethanol or ethanol containing less than 40% by weight of propylene glycol and water, said liquid preparation comprising 0.5 to 2.0% by weight of clotrimazole, 2 to 10% by weight of crotamiton, 30 to 60% by weight of ethanol or propylene glycol-containing ethanol, and remainder of water.
References Cited (Backward Citations)
US3660577A
Cited
US3660576A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-11 | 1984-11-10 | 1985-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-11 | 1988-11-10 | 1989-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-11 | 1992-11-10 | 1993-05-12 | $7700.00 | Window Closed / Lapsed |