N-trityl-imidazoles as antifungal agents
Abstract
Abstract N-TRITYL-IMIDAZOLES AND SALTS THEREOF OF THE FORMULA: 1-((((X)N-PHENYL),((X'')N-PHENYL),((X")N-PHENYL)-)C-),2-R, WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA: 2-R,4-R1,5-R2-IMIDAZOLE WITH A TRITYL HALIDE OF THE FORMULA: (((X)N-PHENYL),((X'')N-PHENYL),((X")N-PHENYL)-)C-HAL 4-R1,5-R2-IMIDAZOLE WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS.
Inventors
- 👤 Karl-Heinz Buchel
- 👤 Erich Regel
- 👤 Manfred Plompel
Bibliographic Details
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