US5151271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pressure-sensitively adhering composite medicinal preparation
Assignee: Nitto Denko Corp
•
Filing: 1989-10-24
•
Granted: 1992-09-29
•
Expires: 2009-10-24
Abstract
Abstract A pressure-sensitively adhering multilayer medicinal preparation comprises a pressure-sensitively adhering macromolecular substance layer and a polymer layer adjacent thereto and the drug and adjuvant incorporated in said preparation each can migrate from the layer of its original incorporation into the other, said adjuvant being capable of increasing absorption of the drug. In such preparation, the drug amount per unit volume can be increased.
Inventors
- 👤 Saburo Otsuka
- 👤 Yuusuke Ito
- 👤 Toshiyuki Yoshikawa
- 👤 Shoichi Tokuda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K9/7076; A61K9/7084
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
154 words
A process for the preparation of a pressure-sensitively adhering composite medicinal preparation which (1) comprises at least two layers, said layers being (a) a layer of a macromolecular substance, whose glass transition point is within the range from -70° C. to -10° C., having pressure-sensitive adhesiveness at ordinary temperatures and (b) a polymer layer, whose glass transition point is within the range from -50° C. to 75° C., said polymer layer being adjacent to said macromolecular substance layer, (2) one of the said layers (a) and (b) contains a percutaneously absorbable drug and other of said layers contains an adjuvant capable of increasing percutaneous drug absorption, and (3) the drug and adjuvant respectively can immigrate into the adjacent macromolecular substance layer and polymer layer, the process comprising lamenating one of layer (a) and (b) which contains a percutaneously absorbable drug to the other layer which contains an adjuvant capable of increasing percutaneous drug absorption.
Claim 2
Dependent Claim
154 words
A process for the preparation of a pressure-sensitively adhering composite medicinal preparation which (1) comprises at least two layers, said layers being (a) a layer of a macromolecular substance, whose glass transition point is within the range from -70° C. to -10° C., having pressure-sensitive adhesiveness at ordinary temperatures and (b) a polymer layer, whose glass transition point is within the range from -50° C. to 75° C., said polymer layer being adjacent to said macromolecular substance layer, (2) one of the said layers (a) and (b) contains a percutaneously absorbable drug and other of said layers contains an adjuvant capable of increasing percutaneous drug absorption, and (3) the drug and adjuvant respectively can immigrate into the adjacent macromolecular substance layer and polymer layer, the process comprising lamenating one of layer (a) and (b) which contains a percutaneously absorbable drug to the other layer which contains an adjuvant capable of increasing percutaneous drug absorption.
Claim 3
Dependent Claim
22 words
The process of claim 1, wherein the macromolecular substance layer containing the drug is laminated to the polymer layer containing the adjuvant.
Claim 4
Dependent Claim
22 words
The process of claim 1, wherein the macromolecular substance layer containing the adjuvant is laminated to the polymer layer containing the drug.
Claim 5
Dependent Claim
29 words
The process of claim 1, wherein the polymer layer contains at least 10 weight percent of a polymer having a glass transition point of not lower than -50° C.
Claim 6
Dependent Claim
47 words
The process of claim 4, wherein the polymer having a glass transition point of not lower than -50° C. comprises at least one member selected from the group consisting of polyvinyl acetate, copolymers of vinyl acetate and a monomer copolymerizable therewith, and polymers containing an alkoxy (meth)acrylate.
Claim 7
Dependent Claim
13 words
The process of claim 1, wherein the macromolecular substance is an acrylic copolymer.
Claim 8
Dependent Claim
43 words
The process of claim 6, wherein the acrylic copolymer is an acrylic copolymer containing at least 50 weight percent of an alkyl (meth)acrylate, the average number of carbon atoms contained in the alkyl group of said alkyl (meth)acrylate being not smaller than 4.
Claim 9
Dependent Claim
50 words
The process of claim 6, wherein the (meth)acrylic copolymer is composed of at least 50 weight percent of an alkyl (meth)acrylate, not greater than 20 weight percent of a function copolymerizable with said (meth)acrylate and not greater than 40 weight percent of a vinyl ester monomer copolymerizable with said ester.
Claim 10
Dependent Claim
40 words
The process of claim 1, wherein the content of the drug is 0.1-20% by weight based on the total weight of the macromolecular substance layer and polymer layer and the adjuvant content is 1-30% by weight on the same basis.
Claim 11
Dependent Claim
26 words
The process of claim 1, wherein the macromolecular substance layer has a thickness of 5-500 microns and the polymer layer has a thickness of 10-1,000 microns.
Claim 12
Dependent Claim
31 words
The process of claim 1, wherein a film or sheet substantially impermeable to the drug and adjuvant is provided on the side of the polymer layer opposite the macromolecular substance layer.
References Cited (Backward Citations)
DE1228030B
Cited
US3122475A
Cited
GB1108837A
Cited
US3797494A
Cited
US3699963A
Cited
US3742951B1
Cited
US3742951A
Cited
US4031894A
Cited
DE2824288A1
Cited
GB1577259A
Cited
GB2021950A
Cited
EP0020777A1
Cited
DE2953327C2
Cited
US4460369A
Cited
US4340043A
Cited
EP0040862A1
Cited
EP0040861A1
Cited
EP0013606B1
Cited
US4286592A
Cited
GB2073588A
Cited
DE3111550A1
Cited
GB2086224A
Cited
GB2087234A
Cited
US4420470A
Cited
GB2093694A
Cited
DE3208853A1
Cited
GB2095108A
Cited
US4483846A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-29 | 1996-03-30 | 1996-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-29 | 2000-03-30 | 2000-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-29 | 2004-03-30 | 2004-09-29 | $7700.00 | Window Closed / Lapsed |