EP0040862A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Burn matrix, method of its preparation and delivery device comprising said matrix
Assignee: Key Pharmaceuticals Inc
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Filing: 1980-01-04
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Granted: —
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Expires: 2000-01-04
Abstract
Abstract This invention provides a burn matrix comprising glycerol, polyvinylalcohol, a water-soluble polymer having hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and water. The matrix may further include a drug for topical or transdermal application to a patient. The invention also provides a method of making the matrix and a delivery device incorporating the matrix. The matrix may be used in the form of a package, which comprises the matrix (14) embedded in a backing member (10) provided with a detachable cover layer (12). Before use, the cover layer is removed, and the backing member applied to the patient by means of a pressure-sensitive adhesive layer (26), so that the matrix (14) is held against the skin of the patient.
Inventors
- 👤 Alec D. Pennsylvania State University Keith
- 👤 Wallace Pennsylvania State University Snipes
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 00:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/56; A61K31/565; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/42; A61L15/44; A61L2300/00; A61L2300/40; A61L2300/402; A61L2300/404
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
66 words
A burn matrix comprising from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-solubl ' e polymer with hydration sites which in combination with the remaining ingredients yield a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.
Claim 2
Dependent Claim
66 words
A burn matrix comprising from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-solubl ' e polymer with hydration sites which in combination with the remaining ingredients yield a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.
Claim 3
Dependent Claim
51 words
A burn matrix as claimed in claim 1, wherein the matrix is cured and comprises from about 2 to about 55 % of glycerol, from about 4 to about 30 % of polyvinylalcohol, from about 2 to about 20 % of the water-soluble polymer having hydration sites, and the balance water.
Claim 4
Dependent Claim
23 words
A burn matrix as claimed in claim 1 or 2, wherein the water-soluble polymer is polyvinylpyrrolidone, agar, agarose or a water-soluble cellulose derivative.
Claim 5
Dependent Claim
47 words
A burn matrix as claimed in any one of claims 1 to 3, wherein the polyvinylalcohol has a molecular weight of from about 100,000 to about 150,000, and the polyvinylpyrrolidone, when present as the water-soluble polymer, has a molecular weight of from about 20,000 to about 60,000.
Claim 6
Dependent Claim
57 words
A burn matrix as claimed in any one of claims 1 to 4, having dispersed therein a therapeutically effective amount of at least one drug suitable for transdermal delivery to a patient, or containing or having deposited on the surface thereof a therapeutically effective amount of at least one drug suitable for topical delivery to a patient.
Claim 7
Dependent Claim
27 words
A burn matrix as claimed in claim 5, wherein the topical drug is an antibiotic, a local anesthetic, an analgesic, a fungicide, a bactericide, or an anti-micoplasma.
Claim 8
Dependent Claim
30 words
A burn treatment device comprising a burn matrix as claimed in any one of claims 1 to 6, and means for securing said matrix to the skin of a patient.
Claim 9
Independent Claim
70 words
A method of making a burn matrix comprising, in an uncured state and on a weight basis, from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-soluble polymer having hydration sites, and the balance water, which method comprises mixing the constituents, heating the mixture and casting the mixture to form the matrix.
Claim 10
Independent Claim
70 words
A method of making a burn matrix comprising, in an uncured state and on a weight basis, from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-soluble polymer having hydration sites, and the balance water, which method comprises mixing the constituents, heating the mixture and casting the mixture to form the matrix.
Claim 11
Dependent Claim
56 words
A method as claimed in claim 8, comprising the following steps: (a) mixing the glycerol with water; (b) dissolving the polyvinylalcohol and the water-soluble polymer having hydration sites in the mixture of (a) by stirring and heating to from about 90 to about 95°C; and (c) casting the mixture to form sheets of the diffusion matrix.
Claim 12
Dependent Claim
64 words
A method as claimed in claim 9, including the additional step of curing the matrix obtained in (c) to produce a cured matrix comprising, on a weight basis, from about 2 to about 55 % of glycerol, from about 4 to about 30 % of polyvinylalcohol, from about 2 to about 20 % of the water-soluble polymer having hydration sites, and the balance water.
Claim 13
Independent Claim
47 words
A method as claimed in any one of claims 8 to 10, wherein a therapeutically effective amount of at least one drug suitable for transdermal or topical application to a patient is added to and dispersed in the mixture or deposited on the surface of the matrix.
Claim 14
Dependent Claim
41 words
A matrix as defined in any of claims 1 to 6, or when made by a method as claimed in any of claims 8 to 11, or a device as claimed in claim 7, for use in the treatment of burns.
Claim 15
Independent Claim
71 words
A method of making a burn matrix comprising, in an uncured state and on a weight basis, from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % oi a water-soluble polymer having hydration sites, and the balance water, which method comprises mixing the constituents heating the mixture, and casting the mixture to form the diffusion matrix.
Claim 16
Independent Claim
71 words
A method of making a burn matrix comprising, in an uncured state and on a weight basis, from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % oi a water-soluble polymer having hydration sites, and the balance water, which method comprises mixing the constituents heating the mixture, and casting the mixture to form the diffusion matrix.
Claim 17
Dependent Claim
56 words
A method as claimed in claim 1, comprising the following steps: (a) mixing the glycerol with water; (b) dissolving the polyvinylalcohol and the water-soluble polymer having hydration sites in the mixture of (a) by stirring and heating to from about 90 to about 95°C; and (c) casting the mixture to form sheets of the diffusion matrix.
Claim 18
Dependent Claim
22 words
A method as claimed in claim 1 or 2, wherein the water-soluble polymer is agar, agarose, polyvinylpyrrolidone or a water-soluble cellulose derivative.
Claim 19
Dependent Claim
66 words
A method as claimed in claim 3, wherein the water-soluble polymer is polyvinylpyrrolidone and including the additional step of curing the matrix obtained in (c) to produce a cured matrix comprising, on a weight basis, from about 2 to about 55 % of glycerol, from about 4 to about 30 % of polyvinylalcohol, from about 2 to about 20 % of polyvinylpyrrolidone, and the balance water.
Claim 20
Independent Claim
41 words
A method as claimed in any one of claims 2 to 4, wherein a therapeutically effective amount of at least one drug suitable for transdermal or topical application to a patient is added to and dispersed in the mixture of (b).
Claim 21
Independent Claim
42 words
A method as claimed in any one of claims 1 to 4, including the additional step of depositing on the surface of the matrix a therapeutically effective amount of at least one drug suitable for transdermal or topical application to a patient.
Claim 22
Dependent Claim
71 words
A burn matrix comprising from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-soluble polymer with hydration sites which in combination with the remaining ingredients yield a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight, for use in the treatment of burns.
Claim 23
Dependent Claim
71 words
A burn matrix comprising from about 2 to about 60 % of glycerol, from about 2 to about 15 % of polyvinylalcohol, from about 2 to about 10 % of a water-soluble polymer with hydration sites which in combination with the remaining ingredients yield a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight, for use in the treatment of burns.
Claim 24
Dependent Claim
51 words
A burn matrix as claimed in claim 7, wherein the matrix is cured and comprises from about 2 to about 55 % of glycerol, from about 4 to about 30 % of polyvinylalcohol, from about 2 to about 20 % of the water-soluble polymer having hydration sites and the balance water.
Claim 25
Dependent Claim
23 words
A burn matrix as claimed in claims 7 or 8, wherein the water-soluble polymer is polyvinylpyrrolidone, agar, agarose or a water-soluble cellulose derivative.
Claim 26
Dependent Claim
47 words
A burn matrix as claimed in any one of claims 7 to 9, wherein the polyvinylalcohol has a molecular weight of from about 100,000 to about 150,000, and the polyvinylpyrrolidone, when present as the water-soluble polymer, has a molecular weight of from about 20,000 to about 60,000.
Claim 27
Dependent Claim
57 words
A burn matrix as claimed in any one of claims 7 to 10, having dispersed therein a therapeutically effective amount of at least one drug suitable for transdermal delivery to a patient, or containing or having deposited on the surface thereof a therapeutically effective amount of at least one drug suitable for topical delivery to a patient.
Claim 28
Dependent Claim
27 words
A burn matrix as claimed in claim 11, wherein the topical drug is an antibiotic, a local anesthetic, an analgesic, a fungicide, a bactericide, or an anti-micoplasma.
References Cited (Backward Citations)
GB1108837A
Cited
US3598123A
Cited
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