US5145668A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluoride containing mouth rinses, dentifrices, and gels
Assignee: American Dental Association
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Filing: 1990-12-21
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Granted: 1992-09-08
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Expires: 2010-12-21
Abstract
Abstract Previous mouthwashes and dentifrices containing fluoride contributed relatively modest amounts of additional fluoride to the tooth surfaces, and scavenged calcium from the teeth. The present invention can deposit significantly more fluoride in the mouth than previously used formulations containing comparable amounts of fluoride, without scavenging calcium from the teeth. The invention includes a method of fluoridating teeth comprising (1) mixing in an aqueous environment a first component comprising a stable, non-toxic soluble calcium salt with a second component comprising a stable, non-toxic readily hydrolyzable complex fluoride compound, resulting in hydrolysis of the fluoride compound and precipitation of calcium fluoride, followed by (2) prompt application of the mixture to tooth surfaces. The invention also contemplates mouth rinses, denifrices, gels or pastes, and chewable tablets for application of the above-described compositions.
Inventors
- 👤 Laurence C. Chow
- 👤 Shozo Takagi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:02
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
121 words
A method for fluoridating teeth with a reactive, multi-component composition comprising: (a) mixing in an aqueous environment, a first component comprising calcium chloride, with a second component comprising sodium fluorosilicate, an acetate salt, and a sufficient quantity of soluble, non-toxic phosphorous salt to maintain the phosphorous concentration of the multi-component compound at no more than about 1×10 -3 mol/L the mixture defining a reactive, multi-component composition having a pH of from about 4.5 to about 5.5, wherein the sodium fluorosilicate of the reactive multi-component composition is hydrolyzed, and calcium fluoride is precipitated from the reactive multi-component composition; and (b) applying the reactive multi-component composition to tooth surfaces for a period of time ranging from about 10 seconds to about 4 minutes.
Claim 2
Independent Claim
121 words
A method for fluoridating teeth with a reactive, multi-component composition comprising: (a) mixing in an aqueous environment, a first component comprising calcium chloride, with a second component comprising sodium fluorosilicate, an acetate salt, and a sufficient quantity of soluble, non-toxic phosphorous salt to maintain the phosphorous concentration of the multi-component compound at no more than about 1×10 -3 mol/L the mixture defining a reactive, multi-component composition having a pH of from about 4.5 to about 5.5, wherein the sodium fluorosilicate of the reactive multi-component composition is hydrolyzed, and calcium fluoride is precipitated from the reactive multi-component composition; and (b) applying the reactive multi-component composition to tooth surfaces for a period of time ranging from about 10 seconds to about 4 minutes.
Claim 3
Dependent Claim
20 words
A method as in claim 1 wherein the mixture is applied to tooth surfaces within about thirty seconds of mixing.
Claim 4
Dependent Claim
35 words
A method as in claim 1 wherein the soluble, non-toxic phosphorous salt is selected from the group consisting of alkali and alkaline phosphorous salts, ammonium salts of phosphorous, salts of orthophosphoric acid or mixtures thereof.
Claim 5
Dependent Claim
27 words
A method as in claim 3 wherein the water soluble, non-toxic salt phosphorous is selected from the group sodium hydrogen phosphate, sodium dihydrogen phosphate, or mixtures thereof.
Claim 6
Dependent Claim
14 words
A method as in claim 1 wherein the aqueous environment is the human mouth.
Claim 7
Dependent Claim
28 words
A method as in claim 1 wherein the aqueous environment is supplied by the first component, by the second component, or by both the first and second component.
Claim 8
Dependent Claim
31 words
A method as in claim 1 wherein the first component and the second component may be in the form of a paste a gel, an aqueous solution, or a combination thereof.
References Cited (Backward Citations)
US4397837A
Cited
US4048300A
Cited
US4108980A
Cited
US4080440A
Cited
US4083955A
Cited
US4177258A
Cited
US4183915A
Cited
US4348381A
Cited
US4460565A
Cited
US4532124A
Cited
US4556561A
Cited
US4861590A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-08 | 1996-03-09 | 1996-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-08 | 2000-03-09 | 2000-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-08 | 2004-03-09 | 2004-09-08 | $7700.00 | Window Closed / Lapsed |