US4556561A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions and methods for topically fluoridating and/or mineralizing dental tissue
Assignee: American Dental Association
•
Filing: 1985-02-05
•
Granted: 1985-12-03
•
Expires: 2005-02-05
Abstract
Abstract Solutions, gels, and substantially nonaqueous dispersions that form dicalcium phosphate dihydrate under appropriate conditions are disclosed, as well as methods for their use. These compositions are useful in topically fluoridating and/or mineralizing dental tissue, such as enamel, dentin, and exposed root surfaces. The incorporated fluoride is in the form of Ca5(PO4)3F and is more permanently retained than CaF2 and other fluoridation products.
Inventors
- 👤 Walter E. Brown
- 👤 Laurence C. Chow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 08:03
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61Q; A61Q11/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
211 words
A method for topically fluoridating and/or mineralizing dental tissue such that Ca 5 (PO 4 ) 3 is incorporated into the tissue, comprising in combination the following steps: (a) treating the surface of the tissue with a substantially nonaqueous dispersion such that CaHPO 4 .2H 2 O is formed in the surface of the tissue, the dispersion containing (1) Ca 5 (PO 4 ) 3 F and (2) at least one calcium phosphate compound selected from the group consisting of Ca(H 2 PO 4 ) 2 .H 2 O and Ca(H 2 PO 4 ) 2 , the treatment step occurring in the presence of a dilute aqueous solvent such that the dispersion and the solvent form an aqueous solution or gel containing calcium and phosphate ions in concentrations greater than or equal to approximately fifty percent of the saturation concentration for CaHPO 4 .2H 2 O in the solution or gel, the solution or gel being saturated with respect to Ca 5 (PO 4 ) 3 F, and the solution or gel having a pH less then or equal to approximately 4.3; and (b) applying a fluoridation agent selected from the group consisting of acidulated phosphate fluoride, SnF 2 , NaF and TiF 4 to the surface of the tissue.
Claim 2
Independent Claim
211 words
A method for topically fluoridating and/or mineralizing dental tissue such that Ca 5 (PO 4 ) 3 is incorporated into the tissue, comprising in combination the following steps: (a) treating the surface of the tissue with a substantially nonaqueous dispersion such that CaHPO 4 .2H 2 O is formed in the surface of the tissue, the dispersion containing (1) Ca 5 (PO 4 ) 3 F and (2) at least one calcium phosphate compound selected from the group consisting of Ca(H 2 PO 4 ) 2 .H 2 O and Ca(H 2 PO 4 ) 2 , the treatment step occurring in the presence of a dilute aqueous solvent such that the dispersion and the solvent form an aqueous solution or gel containing calcium and phosphate ions in concentrations greater than or equal to approximately fifty percent of the saturation concentration for CaHPO 4 .2H 2 O in the solution or gel, the solution or gel being saturated with respect to Ca 5 (PO 4 ) 3 F, and the solution or gel having a pH less then or equal to approximately 4.3; and (b) applying a fluoridation agent selected from the group consisting of acidulated phosphate fluoride, SnF 2 , NaF and TiF 4 to the surface of the tissue.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the phosphate compound is Ca(H 2 PO 4 ) 2 .H 2 O.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the dilute aqueous solvent is saliva.
Claim 5
Dependent Claim
34 words
The method of claim 1 wherein the substantially nonaqueous dispersion additionally comprises at least one compound selected from the group consisting of CaHPO 4 .2H 2 O, CaHPO 4 , and CaF 2 .
Claim 6
Dependent Claim
85 words
A substantially nonaqueous dispersion for topically fluoridating and/or mineralizing dental tissue, comprising (1) Ca 5 (PO 4 ) 3 F and (2) at least one calcium phosphate compound selected from the group consisting of Ca(H 2 PO 4 ) 2 .H 2 O and Ca(H 2 PO 4 ) 2 , such that CaHPO 4 .2H 2 O is formed in the surface of the tissue when the surface of the tissue is treated with the dispersion in the presence of a dilute aqueous solvent.
Claim 7
Dependent Claim
85 words
A substantially nonaqueous dispersion for topically fluoridating and/or mineralizing dental tissue, comprising (1) Ca 5 (PO 4 ) 3 F and (2) at least one calcium phosphate compound selected from the group consisting of Ca(H 2 PO 4 ) 2 .H 2 O and Ca(H 2 PO 4 ) 2 , such that CaHPO 4 .2H 2 O is formed in the surface of the tissue when the surface of the tissue is treated with the dispersion in the presence of a dilute aqueous solvent.
Claim 8
Dependent Claim
19 words
The dispersion of claim 5 wherein the phosphate compound is Ca(H 2 PO 4 ) 2 .H 2 O.
Claim 9
Dependent Claim
29 words
The dispersion of claim 5 additionally comprising at least one compound selected from the group consisting of CaHPO 4 .2H 2 O, CaHPO 4 , and CaF 2 .
References Cited (Backward Citations)
US3337412A
Cited
US4048300A
Cited
US4108980A
Cited
US4139599A
Cited
US4080440A
Cited
US4097588A
Cited
US4083955A
Cited
US4267167A
Cited
US4198394A
Cited
US4177258A
Cited
US4183915A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-02 | 1989-06-03 | 1989-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-02 | 1993-06-03 | 1993-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-02 | 1997-06-03 | 1997-12-03 | $7700.00 | Window Closed / Lapsed |