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US4183915A Expired / Lapsed US ⏱️ 0.0 years remaining

Stable solution for dental remineralization

Assignee: Colgate Palmolive Co
•
Filing: 1978-10-13
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Granted: 1980-01-15
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Expires: 1998-10-13
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Abstract

Abstract An aqueous solution useful for remineralizing subsurface carious lesions of dental enamel which solution contains sources of calcium ions and phosphate ions as well as fluoride ions and further includes as an agent to stabilize the solution against precipitation, an antinucleating agent such as ethylenediamine tetramethylenephosphonic acid or water soluble salt thereof, the pH of the solution being about 5-9, preferably close to physiological conditions, such as about 6.8-7.5.

Inventors

  • 👤 Maria C. S. Gaffar
  • 👤 Abdul Gaffar

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 20:52
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/24; A61K8/30; A61K8/55; A61K8/72; A61K8/81; A61K8/8141; A61K8/8147; A61P; A61P1/00; A61P1/02

Claims Analysis

Total Claims: 18
Claim 1
Independent Claim 223 words
A stable aqueous remineralizing solution comprising water having dissolved therein a source of calcium ions and a source of phosphate ions, the amount of calcium ions and phosphate ions being sufficient to effect remineralization of dental enamel; a compound which provides fluoride anticaries agent; and an antinucleating agent selected from the group of acids and orally acceptable water-soluble salts thereof consisting of: diamine tetramethylenephosphonic acids of the formula (M 2 O 3 PH 2 C) 2 N(CH 2 ) n N(CH 2 PO 3 M 2 ) 2 , wherein n is an integer from 1-10; phosphonoacetic acid or salt thereof of the formula M 2 O 3 PCH 2 COOM; peroxydiphosphate of the formula M 4 P 2 O 8 ; an oligomer ##STR3## in which M is hydrogen or an orally acceptable cation: R 1 , R 2 , R 3 , and R 4 are independently hydrogen, methyl or ethyl; Y is at least one hydrophilic member of the group consisting of --COOM, --CONH 2 and CH 2 OH; X is at least one hydrophobic member of the group consisting of --CN, --COOR, --COOR 5 OR, --CONHR and --COONHR 4 COR; R is C 1-8 alkyl; R 5 is C 1-4 alkylene; a is 0-7 and a+b is about 4-15; said solution having a pH of about 5 to 9.
Claim 2
Dependent Claim 223 words
A stable aqueous remineralizing solution comprising water having dissolved therein a source of calcium ions and a source of phosphate ions, the amount of calcium ions and phosphate ions being sufficient to effect remineralization of dental enamel; a compound which provides fluoride anticaries agent; and an antinucleating agent selected from the group of acids and orally acceptable water-soluble salts thereof consisting of: diamine tetramethylenephosphonic acids of the formula (M 2 O 3 PH 2 C) 2 N(CH 2 ) n N(CH 2 PO 3 M 2 ) 2 , wherein n is an integer from 1-10; phosphonoacetic acid or salt thereof of the formula M 2 O 3 PCH 2 COOM; peroxydiphosphate of the formula M 4 P 2 O 8 ; an oligomer ##STR3## in which M is hydrogen or an orally acceptable cation: R 1 , R 2 , R 3 , and R 4 are independently hydrogen, methyl or ethyl; Y is at least one hydrophilic member of the group consisting of --COOM, --CONH 2 and CH 2 OH; X is at least one hydrophobic member of the group consisting of --CN, --COOR, --COOR 5 OR, --CONHR and --COONHR 4 COR; R is C 1-8 alkyl; R 5 is C 1-4 alkylene; a is 0-7 and a+b is about 4-15; said solution having a pH of about 5 to 9.
Claim 3
Dependent Claim 20 words
The stable aqueous remineralizing solution claimed in claim 1 wherein the pH of said solution is about 6.8 and 7.5.
Claim 4
Dependent Claim 23 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said antinucleating agent is present in amount of about 1 to 500 ppm.
Claim 5
Dependent Claim 23 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said antinucleating agent is said diamine tetramethylenephosphonic acid or orally acceptable salt thereof.
Claim 6
Dependent Claim 23 words
The stable aqueous remineralizing solution claimed in claim 4 wherein said antinucleating agent is ethylene diamine tetramethylenephosphonic acid or orally acceptable salt thereof.
Claim 7
Dependent Claim 22 words
This stable aqueous remineralizing solution claimed in claim 1 wherein said antinucleating agent is said phosphonoacetic acid or orally acceptable salt thereof.
Claim 8
Dependent Claim 19 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said antinucleating agent is said an orally acceptable peroxydiphosphate.
Claim 9
Dependent Claim 21 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said antinucleating agent is said oligomer or orally acceptable salt thereof.
Claim 10
Dependent Claim 15 words
The stable aqueous remineralizing solution claimed in claim 1 wherein an electrolyte salt is present.
Claim 11
Dependent Claim 38 words
The stable aqueous remineralizing solution claimed in claim 1 wherein the mole ratio of calcium to phosphate is from about 0.01 to about 100:1 and at least about 50 ppm of each of calcium and phosphate is present.
Claim 12
Dependent Claim 34 words
The stable aqueous remineralizing solution claimed in claim 10 wherein said source of calcium ions and of phosphate ions is hydroxyapatite and the mole ratio of calcium to phosphate is about 1.67 to 1.
Claim 13
Dependent Claim 23 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said source of calcium ions and of phosphate ions is di calcium phosphate.
Claim 14
Dependent Claim 27 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said source of calcium ions is calcium chloride and said source of phosphate ions is sodium phosphate.
Claim 15
Dependent Claim 25 words
The stable aqueous remineralizing solution claimed in claim 1 wherein said compound which provides fluoride anticaries agent provides about 1 ppm to about 1000 ppm.
Claim 16
Dependent Claim 20 words
The stable aqueous remineralizing solution claimed in claim 14 wherein said compound which provides fluoride anticaries agent is sodium monofluorophosphate.
Claim 17
Dependent Claim 21 words
A mouthwash comprising a non-toxic lower aliphatic alcohol carrier and incorporated therein the stable aqueous remineralizing solution claimed in claim 1.
Claim 18
Dependent Claim 23 words
A mouthwash as claimed in claim 16 wherein said alcohol is ethanol and said solution is about 20-80% by weight of said mouthwash.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-01-14 1983-07-16 1984-01-15 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-01-14 1987-07-16 1988-01-15 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-01-14 1991-07-16 1992-01-15 $7700.00 Window Closed / Lapsed

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