US4532124A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dental rinse
Assignee: Development Finance Corp of New Zealand
•
Filing: 1982-08-16
•
Granted: 1985-07-30
•
Expires: 2002-08-16
Abstract
Abstract The specification describes a dry composition and aqueous solution useful in the mineralization of dental plaque. The solution contains 0.01 to 50% W/V of a substance metabolized by bacteria in plaque (urea is exemplified) to raise the pH of said solution, a physiologically acceptable source of calcium ions and a physiologically acceptable source of phosphate ions, both in concentrations to form a stable solution with respect to a calcium phosphate salt, and optionally a fluoride ion generating compound metabolized by bacteria in plaque to release fluoride ions and/or a water soluble fluoride salt, the pH of the solution being from 1 to 9, and the pH and calcium and phosphate ion concentrations being such that the solution remains stable and with respect to the calcium phosphate salt until the substance is metabolized by bacteria in plaque. Results of some dental trials are presented.
Inventors
- 👤 Euan I. F. Pearce
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:25
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/24; A61K8/30; A61K8/40; A61K8/42
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
101 words
In the art or method of mineralizing dental plaque, the improvement consisting of the step of treating said plaque with a plaque mineralizing aqueous solution comprising 0.01 to 50% W/V of urea, a physiologically acceptable water-soluble fluoride salt, a physiologically acceptable water-soluble calcium salt and a physiologically acceptable water-soluble phosphate salt, the pH of the solution being from 1 to 9; said salts being present in concentrations such that the pH and fluoride, calcium and phosphate ion concentrations are such that the solution remains stable with respect to a calcium phosphate salt until said urea is metabolized by bacteria in plaque.
Claim 2
Dependent Claim
101 words
In the art or method of mineralizing dental plaque, the improvement consisting of the step of treating said plaque with a plaque mineralizing aqueous solution comprising 0.01 to 50% W/V of urea, a physiologically acceptable water-soluble fluoride salt, a physiologically acceptable water-soluble calcium salt and a physiologically acceptable water-soluble phosphate salt, the pH of the solution being from 1 to 9; said salts being present in concentrations such that the pH and fluoride, calcium and phosphate ion concentrations are such that the solution remains stable with respect to a calcium phosphate salt until said urea is metabolized by bacteria in plaque.
Claim 3
Dependent Claim
18 words
A method employing a solution according to claim 1, wherein said fluroide salt is also a phosphate salt.
Claim 4
Dependent Claim
36 words
A method employing a solution according to claim 1, wherein said fluoride salt is Na 2 PO 3 F present in a concentration such that the total fluoride concentration in the solution is about 5 mM.
Claim 5
Dependent Claim
18 words
A method employing a solution according to claim 1, wherein the pH is from about 4 to 5.
Claim 6
Dependent Claim
68 words
A method employing a solution according to claim 1 in the form of a mouth rinse which comprises an aqueous solution comprising 3% (W/V) urea, 20 mM calcium chloride, 12 mM sodium dihydrogen phosphate, 4.72 mM sodium monofluorophosphate, 0.28 mM sodium fluoride, 5% (V/V) glycerol, saccharine, spearmint and vanilla in amounts sufficient to increase palatability, and food color, said solution being adjusted to a pH of about 5.0.
Claim 7
Dependent Claim
61 words
A solution in the form of a mouth rinse which comprises an aqueous solution comprising 3% (V/V) urea, 20 mM calcium chloride, 12 mM sodium dihydrogen phosphate, 4.72 mM sodium monofluorophosphate, 0.28 mM sodium fluoride, 5% (v/v) glycerol, saccharine, spearmint and vanilla in amount sufficient to increase palatability, and food color, said solution being adjusted to a pH of about 5.0.
Claim 8
Dependent Claim
61 words
A solution in the form of a mouth rinse which comprises an aqueous solution comprising 3% (V/V) urea, 20 mM calcium chloride, 12 mM sodium dihydrogen phosphate, 4.72 mM sodium monofluorophosphate, 0.28 mM sodium fluoride, 5% (v/v) glycerol, saccharine, spearmint and vanilla in amount sufficient to increase palatability, and food color, said solution being adjusted to a pH of about 5.0.
References Cited (Backward Citations)
US2069157A
Cited
US2542518A
Cited
US2542886A
Cited
US2601238A
Cited
US2588992A
Cited
GB1090340A
Cited
GB1222197A
Cited
DE2118477A1
Cited
US3943241A
Cited
GB1408922A
Cited
US4397837A
Cited
US4048300A
Cited
US4108980A
Cited
US3957967A
Cited
DE2430280A1
Cited
DE2338177A1
Cited
DE2442712A1
Cited
GB1477823A
Cited
DE2404494A1
Cited
DE2409755A1
Cited
DE2409757A1
Cited
DE2409756A1
Cited
US3929988A
Cited
US4080440A
Cited
US4083955A
Cited
US4277464A
Cited
US4267167A
Cited
DE2647870A1
Cited
US4078053A
Cited
US4154813A
Cited
US4203966A
Cited
US4198394A
Cited
US4177258A
Cited
US4183915A
Cited
WO1980002642A1
Cited
US4348381A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-29 | 1989-01-28 | 1989-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-29 | 1993-01-28 | 1993-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-29 | 1997-01-28 | 1997-07-30 | $7700.00 | Window Closed / Lapsed |