Patent US2432608A successfully refreshed from Google Patents.
Patent US5140161A successfully refreshed from Google Patents.
US5140161A
Expired / Lapsed
US
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Capillary flow device
Assignee: Roche Diagnostics Operations Inc
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Filing: 1991-07-23
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Granted: 1992-08-18
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Expires: 2011-07-23
Abstract
Abstract Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastics devices is also described along with various control devices for use with the basic device.
Inventors
- 👤 Robert S. Hillman
- 👤 Michael E. Cobb
- 👤 Jimmy D. Allen
- 👤 Ian Gibbons
- 👤 Vladimir E. Ostoich
- 👤 Laura J. Winfrey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:30
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5027; B01F; B01F25/00; B01F25/40; B01F25/42; B01F25/43; B01F25/431; B01F25/4316; B01F25/433; B01F25/4338; B01F33/00; B01F33/30; B01F35/00; B01F35/71; B01F35/717; B01F35/7172; B29; B29C; B29C65/00; B29C65/02; B29C65/08; B29C66/00; B29C66/01; B29C66/05; B29C66/302; B29C66/3022; B29C66/30223; B29C66/50; B29C66/51; B29C66/54; G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/82; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905; B01F21/00; B01F2101/00; B01F2101/23; B01F23/00; B01F23/50; B01F23/56; B01L2300/00; B01L2300/08; B01L2300/0809; B01L2300/0816; B01L2300/0825; B01L2300/0861; B01L2300/0864; B01L2300/087; B01L2300/0887; B01L2400/00; B01L2400/04; B01L2400/0403; B01L2400/0406; B01L2400/08; B01L2400/084; B01L2400/086; B29C45/00; B29C59/00; B29C59/16; B29C65/48; B29C65/4895; B29C66/70; B29C66/71; B29C66/73; B29C66/739; B29C66/7392; B29C66/73921; B29C66/90; B29C66/95; B29C66/951; B29C66/9513; B29K; B29K2055/00; B29K2055/02; B29L; B29L2031/00; B29L2031/756; G01N15/00; G01N15/10; G01N15/1012; G01N2015/1016; G01N21/01; G01N21/03; G01N2021/0346; G01N35/00; G01N2035/00465; G01N2035/00514; G01N21/17; G01N21/47; G01N21/49; G01N33/50; G01N33/53; G01N33/543; G01N33/54366
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
105 words
A method for determining an analyte in a blood sample, which comprises: employing a device comprising a capillary passageway which provides the motive force for moving blood into the device, wherein said passageway contains a reagent that interacts with said blood to cause a change in the fluidity of said blood, thereby providing a detectible signal; introducing blood into said capillary passageway; allowing said blood to transit at least a portion of said passageway and react with said reagent; and detecting a change in the fluidity of said blood as a measure of the presence of an analyte in or property of said blood sample.
Claim 2
Independent Claim
105 words
A method for determining an analyte in a blood sample, which comprises: employing a device comprising a capillary passageway which provides the motive force for moving blood into the device, wherein said passageway contains a reagent that interacts with said blood to cause a change in the fluidity of said blood, thereby providing a detectible signal; introducing blood into said capillary passageway; allowing said blood to transit at least a portion of said passageway and react with said reagent; and detecting a change in the fluidity of said blood as a measure of the presence of an analyte in or property of said blood sample.
Claim 3
Dependent Claim
22 words
A method according to claim 1, wherein said detectable change in fluidity is a change in the flow rate of said sample.
Claim 4
Dependent Claim
18 words
A method according to claim 1, wherein said detectable change in fluidity is clotting of said blood sample.
Claim 5
Dependent Claim
18 words
A method according to claim 1 wherein said detectable signal is a change in light transmission or emission.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-18 | 1996-02-17 | 1996-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-18 | 2000-02-17 | 2000-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-18 | 2004-02-17 | 2004-08-18 | $7700.00 | Window Closed / Lapsed |