US5132290A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Esters of 3'-deaminodoxorubicin and liposomal compositions thereof
Assignee: The University of Texas System
•
Filing: 1989-05-30
•
Granted: 1992-07-21
•
Expires: 2009-05-30
Abstract
Abstract Three'-deaminodoxorubicin esters have been found to have excellent encapsulization efficiency in liposomes and to display high antineoplastic activity. The liposomal formulations have also been found to be quite stable.
Inventors
- 👤 Waldemar Priebe
- 👤 Roman Perez-Soler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 10:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61P; A61P35/00; C; C07; C07H; C07H15/00; C07H15/20; C07H15/207
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
16 words
A compound having the formula ##STR3## or a pharmaceutically acceptable salt thereof, where R is palmitoyl.
Claim 2
Dependent Claim
16 words
A compound having the formula ##STR3## or a pharmaceutically acceptable salt thereof, where R is palmitoyl.
Claim 3
Dependent Claim
26 words
A composition comprising a compound having the formula ##STR4## or a pharmaceutically acceptable salt thereof, where R is palmitoyl, the compound being encapsulated in a liposome.
Claim 4
Dependent Claim
26 words
A composition comprising a compound having the formula ##STR4## or a pharmaceutically acceptable salt thereof, where R is palmitoyl, the compound being encapsulated in a liposome.
Claim 5
Dependent Claim
30 words
The composition of claim 2, where the liposome comprises dimyristoylphosphatidyl choline, dimyristoylphosphatidyl glycerol, and a compound having a formula specified in claim 5, in an approximate weight ratio of 1.5:4.5:1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-21 | 1996-01-20 | 1996-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-21 | 2000-01-20 | 2000-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-21 | 2004-01-20 | 2004-07-21 | $7700.00 | Window Closed / Lapsed |