US4035566A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
Assignee: Dana Farber Cancer Institute Inc
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Filing: 1975-09-25
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Granted: 1977-07-12
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Expires: 1995-09-25
Abstract
Abstract Esters of C4-C10 saturated fatty acids with N-trifluoroacetyladriamycin are novel compounds. These compounds have the following structure: <IMAGE> in which A is alkanoate having from 4 to 10 carbon atoms. Therapeutic compositions containing these compounds or the acetate or propionate of N-trifluoroacetyladriamycin are more effective than adriamycin in antitumor activity against murine P 388 and L 1210 leukemias and Ridgway osteogenic sarcoma in mice and at the same time significantly less toxic than adriamycin.
Inventors
- 👤 Mervyn Israel
- 👤 Edward J. Modest
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:41
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
16 words
N-trifluoroacetyladriamycin-14-alkanoates in which the alkanoate portion of the molecule contains from 4 to 10 carbon atoms.
Claim 2
Dependent Claim
16 words
N-trifluoroacetyladriamycin-14-alkanoates in which the alkanoate portion of the molecule contains from 4 to 10 carbon atoms.
Claim 3
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is pentanoate.
Claim 4
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is valerate.
Claim 5
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is butanoate.
Claim 6
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is isobutyrate.
Claim 7
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is hexanoate.
Claim 8
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is caproate.
Claim 9
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is octanoate.
Claim 10
Dependent Claim
12 words
The compound claimed in claim 1 in which the alkanoate is caprylate.
References Cited (Backward Citations)
US3803124A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-11 | 1981-01-10 | 1981-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-11 | 1985-01-10 | 1985-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-11 | 1989-01-10 | 1989-07-12 | $7700.00 | Window Closed / Lapsed |