US5130142A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor
Assignee: Procter and Gamble Co
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Filing: 1990-10-31
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Granted: 1992-07-14
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Expires: 2010-10-31
Abstract
Abstract The present invention relates to a composition for regulating hair growth comprising a safe and effective amount of a supernatant derived from a culture of epithelial cells which comprises a growth stimulating factor with characteristics of mitogenicity to dermal papilla cells, mitogenicity to 3T3 cells, lack of mitogenicity to epidermal cells, and a molecular weight of greater than about 3,000D; and a pharmaceutically-acceptable carrier.
Inventors
- 👤 Teresa K. Wong
- 👤 Raphael Warren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:45
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; A; A61; A61K; A61K35/00; A61K35/12; A61K35/36; A61K8/00; A61K8/18; A61K8/96; A61K8/98; A61K8/981; A61K8/985; A61Q; A61Q7/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
69 words
A composition for regulating hair growth comprising: a. a safe and effective amount of a supernatant derived from a culture of epithelial cells which comprises a growth stimulating factor, the factor having the following characteristics: i. mitogenicity to dermal papilla cells, ii. mitogenicity to 3T3 cells, iii. lack of mitogenicity to epidermal cells, and iv. a molecular weight of greater than about 3,000 daltons; and b. a pharmaceutically-acceptable carrier.
Claim 2
Dependent Claim
69 words
A composition for regulating hair growth comprising: a. a safe and effective amount of a supernatant derived from a culture of epithelial cells which comprises a growth stimulating factor, the factor having the following characteristics: i. mitogenicity to dermal papilla cells, ii. mitogenicity to 3T3 cells, iii. lack of mitogenicity to epidermal cells, and iv. a molecular weight of greater than about 3,000 daltons; and b. a pharmaceutically-acceptable carrier.
Claim 3
Dependent Claim
46 words
The composition of claim 1 wherein the growth stimulating factor has the additional characteristic of decreased dermal papilla cell mitogen assay activity following treatment with chymotrypsin type I-S at a final concentration of up to about 100 μg/ml at about 37° C. for about 5 hours.
Claim 4
Dependent Claim
42 words
The composition of any of claims 1 or 2 wherein the growth stimulating factor has the additional characteristic of retaining from about 40% to about 90% dermal papilla cell mitogen assay activity following heat treatment from about 50° to about 100° C.
Claim 5
Dependent Claim
27 words
The composition of claim 1 wherein the composition comprises from about 0.01% to about 10% of the growth stimulating factor and the carrier is a topical carrier.
Claim 6
Dependent Claim
13 words
The composition of claim 4 wherein the cells are hair follicle epithelial cells.
Claim 7
Dependent Claim
11 words
The composition of claim 4 wherein the cells are epidermal cells.
Claim 8
Dependent Claim
12 words
The composition of claim 1 wherein the carrier is an injectable carrier.
Claim 9
Dependent Claim
19 words
The composition of claim 4 wherein the topical carrier comprises from about 1% to about 50% of an emollient.
Claim 10
Dependent Claim
15 words
The composition of claim 1 which additionally comprises a safe and effective amount of minoxidil.
Claim 11
Independent Claim
27 words
A method of regulating hair growth which comprises topically applying to mammalian skin or hair any of the compositions of claims 1, 4, 5, 6 or 8.
Claim 12
Dependent Claim
16 words
A method of regulating hair growth which comprises cutaneous injection of the composition of claim 1.
References Cited (Backward Citations)
US2551A
Cited
US101722A
Cited
US110058A
Cited
US253594A
Cited
US260570A
Cited
US321487A
Cited
US421675A
Cited
US578632A
Cited
US1732120A
Cited
US3466364A
Cited
US4139619A
Cited
JPS615006A
Cited
FR2571615A1
Cited
EP0215274B1
Cited
EP0236014A1
Cited
EP0272920A1
Cited
US4832946A
Cited
WO1989007425A2
Cited
US5037643A
Cited
EP0352894A2
Cited
WO1990006100A1
Cited
US5091173A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-14 | 1996-01-13 | 1996-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-14 | 2000-01-13 | 2000-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-14 | 2004-01-13 | 2004-07-14 | $7700.00 | Window Closed / Lapsed |