EP0236014A1
Expired / Lapsed
EP
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Stimulation of hair growth
Assignee: University of Dundee
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Filing: 1987-02-19
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Granted: —
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Expires: 2007-02-19
Abstract
Abstract The present invention relates to a method of stimulating hair growth in part of the skin of a mammal. The method comprises selecting lower follicular dermal cells and culturing them. An opening is then formed in the skin and the cultured dermal cells introduced through the opening in the outer epidermis layer of the skin into contact with the dermis, with said cultured dermal cells in association with epidermis cells.The invention also provides a hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermis cells, as well as such cultured dermal cells for use in the preparation of an injection composition for stimulating hair growth in human skin.
Inventors
- 👤 Roy Frederick Oliver
- 👤 Colin Albert Buchanan Jahoda
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 10:05
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0625; C12N5/0627; A; A61; A61K; A61K35/00; A61K35/12; A61K35/36; A61K8/00; A61K8/18; A61K8/96; A61K8/98; A61K8/981; A61K8/985; A61Q; A61Q7/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
94 words
A method of stimulating hair growth of a desired hair type in part of the skin of a mammal which method comprises the steps of: selecting at least one lower follicular dermal cell of said desired hair type; culturing the selected dermal cell(s) so as to produce cultured dermal cells; forming an opening in the skin of said part of the mammal; and introducing cultured dermal cells through said opening in the epidermis into contact with the dermis in proximity to the epidermis and with said cultured dermal cells in association with epidermal cells.
Claim 2
Independent Claim
94 words
A method of stimulating hair growth of a desired hair type in part of the skin of a mammal which method comprises the steps of: selecting at least one lower follicular dermal cell of said desired hair type; culturing the selected dermal cell(s) so as to produce cultured dermal cells; forming an opening in the skin of said part of the mammal; and introducing cultured dermal cells through said opening in the epidermis into contact with the dermis in proximity to the epidermis and with said cultured dermal cells in association with epidermal cells.
Claim 3
Dependent Claim
31 words
A method as claimed in claim 1 wherein said cultured dermal cells introduced through said opening are subjected to physical and/or biochemical aggregation thereby to enhance interaction with said epidermal cells.
Claim 4
Dependent Claim
21 words
A method as claimed in claim 2 wherein said cultured dermal cells are treated with an aggregation promoting glycoprotein or glycosaminoglycan.
Claim 5
Independent Claim
31 words
A method as claimed in any one of claims 1 to 3 wherein said opening is in the form of a narrow incision having a depth of from 0.4 to 6mm.
Claim 6
Independent Claim
52 words
A method as claimed in any one of claims 1 to 4 which method includes the step of inducing a blister in said part of the skin, and wherein said opening is made in part of the epidermis at said blister, and said cultured dermal cells are introduced into the blister cavity.
Claim 7
Independent Claim
24 words
A method as claimed in any one of claims 1 to 4 wherein the cultured dermal cells are enclosed inside a pocket of epidermis.
Claim 8
Independent Claim
27 words
A method as claimed in any one of claims 1 to 4 wherein the dermal cells are introduced in the form of a mixture with epidermal cells.
Claim 9
Dependent Claim
18 words
A method as claimed in claim 7 wherein are used epidermal cells of inter- or intra- follicular origin.
Claim 10
Independent Claim
38 words
A method as claimed in any one of claims 1 to 8 wherein said mammal is treated with a hair growth stimulating promoter so as to enhance growth of new hair induced by said introduced cultured dermal cells.
Claim 11
Independent Claim
28 words
A method as claimed in any one of claims 1 to 9 wherein said selected dermal cell(s) comprise at least one of dermal papilla and dermal sheath cells.
Claim 12
Independent Claim
22 words
A method as claimed in any one of claims 1 to 10 wherein said selected dermal cells are of human scalp origin.
Claim 13
Dependent Claim
16 words
A hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermal cells.
Claim 14
Dependent Claim
16 words
A hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermal cells.
Claim 15
Dependent Claim
18 words
A combination as claimed in claim 12 wherein said dermal cells are in the form of aggregated clumps.
Claim 16
Dependent Claim
15 words
A combination as claimed in claim 13 which includes a dermal cell aggregation promoting substance.
Claim 17
Dependent Claim
15 words
A combination as claimed in claim 14 wherein said substance is a glycoprotein or glycosaminoglycan.
Claim 18
Dependent Claim
34 words
An injection composition suitable for use in stimulating hair growth which composition comprises a combination as claimed in any one of claims 11 to 14 in intimate admixture with a physiologically acceptable injection vehicle.
Claim 19
Dependent Claim
24 words
A combination comprising cultured lower follicular dermal cells in admixture with epidermal cells, for use in the preparation of a hair growth stimulating substance.
Claim 20
Dependent Claim
24 words
A combination comprising cultured lower follicular dermal cells in admixture with epidermal cells, for use in the preparation of a hair growth stimulating substance.
Claim 21
Dependent Claim
19 words
Cultured human scalp lower follicular dermal cells for use in the preparation of a hair growth stimulating injection composition.
Claim 22
Dependent Claim
19 words
Cultured human scalp lower follicular dermal cells for use in the preparation of a hair growth stimulating injection composition.
References Cited (Backward Citations)
EP0107885A1
Cited
DE3431266A1
Cited
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