US5114718A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release compositions for treating periodontol disease
Assignee: Procter and Gamble Co
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Filing: 1990-09-20
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Granted: 1992-05-19
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Expires: 2010-09-20
Abstract
Abstract This invention relates to devices/compositions and methods for treating diseases of the oral cavity in humans and lower animals using non-biodegradable devices/compositions which are biocompatible but not bioerodible for releasing drugs in or around a periodontol pocket or gingival sulcus.
Inventors
- 👤 Nalinkant C. Damani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/0012; A61K9/0053; A61K9/0063
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
140 words
A solid composition suitable for insertion into the periodontal pocket or the gingival sulcus of a person or lower animal suffering from diseases of the oral cavity comprising a non-biodegradable, biocompatible polymer selected from the group consisting of polyurethanes, ethylene vinyl acetate copolymers, collagen, poly isobutylene, ethylene vinyl alcohol copolymers, polyethylene polycarbonate, and polyvinyl chloride and a drug active selected from the group consisting of antiinflammatory agents, antimicrobials, antibiotics, peroxides, anesthetic agents, and vitamins in a concentration from about 0.5% to about 95% wherein said composition is in the form of a chip, cone or strip and wherein said composition provides steady state average concentrations of active of from about 10 μg to about 5000 μg, preferably from about 25 μg to about 2500 μg per milliliter of the gingival crevicular fluid of a treated periodontal pocket or gingival sulcus.
Claim 2
Dependent Claim
140 words
A solid composition suitable for insertion into the periodontal pocket or the gingival sulcus of a person or lower animal suffering from diseases of the oral cavity comprising a non-biodegradable, biocompatible polymer selected from the group consisting of polyurethanes, ethylene vinyl acetate copolymers, collagen, poly isobutylene, ethylene vinyl alcohol copolymers, polyethylene polycarbonate, and polyvinyl chloride and a drug active selected from the group consisting of antiinflammatory agents, antimicrobials, antibiotics, peroxides, anesthetic agents, and vitamins in a concentration from about 0.5% to about 95% wherein said composition is in the form of a chip, cone or strip and wherein said composition provides steady state average concentrations of active of from about 10 μg to about 5000 μg, preferably from about 25 μg to about 2500 μg per milliliter of the gingival crevicular fluid of a treated periodontal pocket or gingival sulcus.
Claim 3
Dependent Claim
31 words
A composition according to claim 1 wherein the concentration of the drug active is from about 15% to about 85% and the active is selected from the tetracycline group of antibiotics.
Claim 4
Dependent Claim
40 words
A composition according to claim 1 wherein the composition is formed into a shape of a strip average having a width of about 1 mm, an average thickness of about 0.75 mm, and an average length of about 10 mm.
Claim 5
Dependent Claim
48 words
A composition according to claim 1 wherein the composition is formed into the shape of a cone having an average length of about 15 mm, an average diameter at the wide end of about 1.5 mm, and an average diameter at the pointed end of about 0.25 mm.
Claim 6
Dependent Claim
55 words
A composition according to claim 1 wherein the composition is formed into the shape of a chip having an average length of about 15 mm, an average width at the wide end of about 1.5 mm, and an average width of the pointed end of about 0.5 mm, and average thickness of about 0.8 mm.
Claim 7
Dependent Claim
13 words
A composition according to claim 5 wherein the polymer is ethylene vinyl acetate.
Claim 8
Dependent Claim
17 words
A composition according to claim 6 wherein the active is selected from the tetracycline group of antibiotics.
Claim 9
Dependent Claim
44 words
A method of treating diseases of the oral cavity in a person or lower animal suffering from such disease by placing into the periodontol pocket or around said pocket or gingival sulcus of said person or lower animal a composition according to claim 1.
Claim 10
Dependent Claim
18 words
A method according to claim 8 wherein the drug active is selected from the tetracycline group of antibiotics.
Claim 11
Dependent Claim
55 words
A method according to claim 9 wherein the composition is formed into the shape of a chip having an average length of about 10 mm, an average width of the wide end of about 1 mm, and an average width of the pointed end of about 0.2 mm, and average thickness of about 0.6 mm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-19 | 1995-11-18 | 1996-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-19 | 1999-11-18 | 2000-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-19 | 2003-11-18 | 2004-05-19 | $7700.00 | Window Closed / Lapsed |