US5098893A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Storage of materials
Assignee: Novartis Pharma AG
•
Filing: 1990-02-12
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Granted: 1992-03-24
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Expires: 2010-02-12
Abstract
Abstract A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be stored at ambient temperature. Recovery is by adding aqueous solution to the composition.
Inventors
- 👤 Felix Franks
- 👤 Ross H. M. Hatley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:31
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/96; A; A61; A61K; A61K47/00; A61K47/06; A61K47/26; A61K47/30; A61K47/36; A61K9/00; A61K9/14; A61K9/141; A61K9/145; A61K9/146; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087; C12N11/10
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
62 words
A composition which is storage stable at 20° C. comprising: i) a carrier substance which is water-soluble or water-swellable and is in a glassy amorpous state; ii) at least one material to be stored, which is unstable in aqueous solution at room temperature of 20° C. dissolved in said amorphous carrier substance, said composition existing in a glassy state at 20° C.
Claim 2
Dependent Claim
62 words
A composition which is storage stable at 20° C. comprising: i) a carrier substance which is water-soluble or water-swellable and is in a glassy amorpous state; ii) at least one material to be stored, which is unstable in aqueous solution at room temperature of 20° C. dissolved in said amorphous carrier substance, said composition existing in a glassy state at 20° C.
Claim 3
Dependent Claim
43 words
A composition according to claim 1 wherein the material to be stored is selected from proteins, peptides, nucleosides, nucleotides, dimers or oligomers of nucleosides or nucleotides, enzyme cofactors, and derivatives of any of the foregoing having one or more additional moieties bound thereto.
Claim 4
Dependent Claim
15 words
A composition according to claim 1 having a water content not exceeding 4% by weight.
Claim 5
Dependent Claim
19 words
A composition according to claim 1 wherein the composition displays a glass transition temperature of at least 30° C.
Claim 6
Dependent Claim
20 words
A composition according to claim 1 wherein carrier substance is selected from carbohydrates and derivatives thereof which are polyhydroxy compounds.
Claim 7
Dependent Claim
27 words
A composition according to claim 5 wherein the carrier substance is a sugar polymer containing sugar residues linked through ether bridges to bifunctional groups other than carbohydrate.
Claim 8
Dependent Claim
14 words
A composition according to claim 1 wherein the carrier substance is a synthetic polymer.
Claim 9
Dependent Claim
26 words
A composition according to claim 1 wherein said material to be stored comprises a material which is unstable when alone in aqueous solution at room temperature.
Claim 10
Dependent Claim
17 words
A composition according to claim 1 wherein said material to be stored comprises a plurality of materials.
Claim 11
Dependent Claim
23 words
A composition according to claim 9 wherein said material to be stored comprises a plurality of materials which react together in aqueous solution.
Claim 12
Dependent Claim
17 words
A composition according to claim 1 which can be stored without refrigeration for at least 1 week.
Claim 13
Independent Claim
72 words
A method of rendering a material storage stable at 20° C., which material is unstable in aqueous solution at room temperature of 20° C., comprising dissolving the material in a carrier substance which is water-soluble or water-swellable, or in a solution thereof, so that the material is dissolved in said carrier substance, and forming the resulting mixture into a glassy amorphous state, said mixture existing in said glassy state at 20° C.
Claim 14
Independent Claim
72 words
A method of rendering a material storage stable at 20° C., which material is unstable in aqueous solution at room temperature of 20° C., comprising dissolving the material in a carrier substance which is water-soluble or water-swellable, or in a solution thereof, so that the material is dissolved in said carrier substance, and forming the resulting mixture into a glassy amorphous state, said mixture existing in said glassy state at 20° C.
Claim 15
Dependent Claim
22 words
A method according to claim 12 wherein forming the said mixture into an amorphous state is effected by evaporation under subatmospheric pressure.
Claim 16
Dependent Claim
29 words
A method according to claim 13 wherein evaporation is commenced at a temperature of 20 to 40° C. and subsequently continued at a temperature of 40 to 70° C.
Claim 17
Dependent Claim
17 words
A method according to claim 13 wherein the subatmospheric pressure is not greater than 90% of atmospheric.
Claim 18
Dependent Claim
72 words
In a method of storing a material, which material is unstable in aqueous solution at 20° C., the improvement comprising dissolving the material in a carrier substance which is water-soluble or water-swellable, or in a solution thereof, so that the material is dissolved in said carrier substance, forming the resulting mixture into a glassy amorphous state and storing the mixture in said glassy amorphous state without refrigeration for at least one week.
Claim 19
Dependent Claim
72 words
In a method of storing a material, which material is unstable in aqueous solution at 20° C., the improvement comprising dissolving the material in a carrier substance which is water-soluble or water-swellable, or in a solution thereof, so that the material is dissolved in said carrier substance, forming the resulting mixture into a glassy amorphous state and storing the mixture in said glassy amorphous state without refrigeration for at least one week.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-24 | 1995-09-23 | 1996-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-24 | 1999-09-23 | 2000-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-24 | 2003-09-23 | 2004-03-24 | $7700.00 | Window Closed / Lapsed |