US5080894A
Expired / Lapsed
US
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Method and composition for reducing tissue damage
Assignee: Emory University
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Filing: 1990-05-17
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Granted: 1992-01-14
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Expires: 2010-05-17
Abstract
Abstract In accordance with the present invention, a method and composition is provided for treating an animal or human with ischemic tissue. The method comprises injecting an effective amount of a free-radical scavenger and a surface-active copolymer into an animal or human with damaged tissue. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an interger such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
- 👤 Alexander Duncan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 05:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
91 words
A composition for treating an animal or human with ischemic tissue comprising a solution containing an admixture of: an effective amount of a oxygen free-radical scavenger; and an effective amount of a surface-active copolymer with the following formula: ##STR18## wherein a is an intetger such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 2
Dependent Claim
91 words
A composition for treating an animal or human with ischemic tissue comprising a solution containing an admixture of: an effective amount of a oxygen free-radical scavenger; and an effective amount of a surface-active copolymer with the following formula: ##STR18## wherein a is an intetger such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 3
Dependent Claim
66 words
The composition of claim 1, wherein said surface-active copolymer has the following formula: ##STR19## wherein a is an integer such that the hydrophobe represented by (C 3 h 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 4
Dependent Claim
40 words
The composition of claim 1, wherein said surface-active copolymer has the following formula: ##STR20## wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 5
Dependent Claim
14 words
The composition of claim 1, wherein the oxygen free radical scavenger is superoxide dismutase.
Claim 6
Independent Claim
99 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR21## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 7
Independent Claim
99 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR21## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 8
Dependent Claim
66 words
The method of claim 5, wherein said surfaceactive copolymer has the following formula: ##STR22## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 9
Dependent Claim
39 words
The method of claim 5, wherein said surfaceactive copolymer has the following formula: ##STR23## wherein themolecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 10
Dependent Claim
14 words
The method of claim 5, wherein the oxygen free radical scavenger is superoxide dismutase.
Claim 11
Dependent Claim
18 words
The method of claim 5, wherein the oxygen free radical scavenger and the surface-active copolymer are injected separately.
Claim 12
Independent Claim
100 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting intravenously into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR24## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 13
Independent Claim
100 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting intravenously into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR24## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 14
Dependent Claim
66 words
The method of claim 10, wherein said surfaceactive copolymer has the following formula: ##STR25## wherein a is an integer such taht the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 15
Dependent Claim
40 words
The method of claim 10, wherein said surfaceactive copolymer has the following formula: ##STR26## wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 16
Dependent Claim
15 words
The method of claim 10, wherein the oxygen free radical scavenger is super oxide dismutase.
Claim 17
Dependent Claim
18 words
The method of claim 10, wherein the oxygen free radical scavenger and the surface-active copolymer are injected separately.
Claim 18
Independent Claim
100 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting intramuscularly into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR27## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 19
Independent Claim
100 words
A method for treating an animal or human with ischemic tissue comprising the step of injecting intramuscularly into the animal or human with tissue damage: an effective amount of an oxygen free radical scavenger; and an effective amount of a surface-active copolymer of the following formula: ##STR27## wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 20
Dependent Claim
66 words
The method of claim 15, wherein said surfaceactive copolymer has the following formulat: ##STR28## wherein a is an integer such that the hydrophobe represented by (C 3 h 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 21
Dependent Claim
40 words
The method of claim 15, wherein said surfaceactive copolymer has the following formula: ##STR29## wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 22
Dependent Claim
15 words
The method of claim 15, wherein the oxygen free radical scavenger is super oxide dismutase.
Claim 23
Dependent Claim
18 words
The method of claim 15, wherein the oxygen free radical scavenger and the surface-active copolymer are injected separately.
References Cited (Backward Citations)
US2674619A
Cited
US2854378A
Cited
US3089818A
Cited
US3140232A
Cited
US3740421A
Cited
US3450502A
Cited
US3641240A
Cited
US3577522A
Cited
US3590125A
Cited
US3980772A
Cited
US3867521A
Cited
US3956259A
Cited
US4073886A
Cited
US4179337A
Cited
JPS525094A
Cited
US4100271A
Cited
US4305922A
Cited
US4186253A
Cited
US4395393A
Cited
US4407790A
Cited
US4609546A
Cited
SU1183112A1
Cited
US4600652A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |