US5078995A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fibrionolytic composition
Assignee: Emory University
•
Filing: 1990-05-11
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Granted: 1992-01-07
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Expires: 2010-05-11
Abstract
Abstract In accordance with present invention, a method is provided for reducing tissue damaged by ischemia in animal or human. The method comprises injecting an effective amount of an anticoagulant and a surface-active copolymer into an animal or human with tissue damaged by ischemia tissue. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
- 👤 Alexander Duncan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
100 words
A composition for treating tissue damaged by ischemia in an animal or human comprising a solution containing an admixture of: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 2
Dependent Claim
100 words
A composition for treating tissue damaged by ischemia in an animal or human comprising a solution containing an admixture of: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 3
Dependent Claim
75 words
The composition of claim 1, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 4
Dependent Claim
49 words
The composition of claim 1, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 5
Dependent Claim
21 words
The composition of claim 1, wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 6
Independent Claim
109 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting into the animal or human with tissue damaged by ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 7
Independent Claim
109 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting into the animal or human with tissue damaged by ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 8
Dependent Claim
75 words
The method of claim 5, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 9
Dependent Claim
49 words
The method of claim 5, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 10
Dependent Claim
21 words
The method of claim 5, wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 11
Dependent Claim
15 words
The method of claim 5, wherein the anticoagulant and the surface-active copolymer are injected separately.
Claim 12
Independent Claim
109 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting intravenously into the animal or human with tissue damaged ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 13
Independent Claim
109 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting intravenously into the animal or human with tissue damaged ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 14
Dependent Claim
75 words
The method of claim 10, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 15
Dependent Claim
49 words
The method of claim 10, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 16
Dependent Claim
21 words
The method of claim 10, wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 17
Dependent Claim
15 words
The method of claim 10, wherein the anticoagulant and the surface-active copolymer are injected separately.
Claim 18
Independent Claim
110 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting intramuscularly into the animal or human with tissue damaged by ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 19
Independent Claim
110 words
A method for treating tissue damaged by ischemia in an animal or human comprising the step of injecting intramuscularly into the animal or human with tissue damaged by ischemia: an effective amount of an anticoagulant; and an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes from approximately 50% to 90% by weight of the compound.
Claim 20
Dependent Claim
75 words
The method of claim 15, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 4 H 4 O) constitutes approximately 50% to 90% by weight of the compound.
Claim 21
Dependent Claim
49 words
The method of claim 15, wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 22
Dependent Claim
21 words
The method of claim 15, wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 23
Dependent Claim
15 words
The method of claim 15, wherein the anticoagulant and the surface-active copolymer are injected separately.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-06 | 1995-07-08 | 1996-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-06 | 1999-07-08 | 2000-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-06 | 2003-07-08 | 2004-01-07 | $7700.00 | Window Closed / Lapsed |