7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents

Claim 1

A method for treating inflammation which comprises administering to a patient in need of said treatment a therapeutically effective amount of a compound in unit dosage form of formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein n is an integer of from one to six; either of X or Y is oxygen and the other is --CH 2 --; R is selected from ##STR14## where R 4 and R 5 are independently hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, or aryl; b) 3,4,5-trimethylphenoxy; ##STR15## where R 6 is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms, or aryl; Z is --CH 2 --, --O--, --S--, or --NR 7 -- where R 7 is hydrogen, alkanoyl of from one to six carbon atoms, or alkyl of from one to six carbon atoms; ##STR16## wherein R 8 and R 9 are independently hydrogen, fluorine, bromine, alkyl of from one to six carbon atoms, or alkoxy of from one to four carbon atoms; or ##STR17## where R 8 and R 9 are as defined above; where R 2 is methyl and R 3 is hydrogen, alkyl of from one to six carbon atoms, ##STR18## where R 10 is alkyl of from one to four carbon atoms; or where R 2 and R 3 when taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl, or hexahydro-1H-azepinyl ring.

Claim 2

A method for treating inflammation which comprises administering to a patient in need of said treatment a therapeutically effective amount of a compound in unit dosage form of formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein n is an integer of from one to six; either of X or Y is oxygen and the other is --CH 2 --; R is selected from ##STR14## where R 4 and R 5 are independently hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, or aryl; b) 3,4,5-trimethylphenoxy; ##STR15## where R 6 is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms, or aryl; Z is --CH 2 --, --O--, --S--, or --NR 7 -- where R 7 is hydrogen, alkanoyl of from one to six carbon atoms, or alkyl of from one to six carbon atoms; ##STR16## wherein R 8 and R 9 are independently hydrogen, fluorine, bromine, alkyl of from one to six carbon atoms, or alkoxy of from one to four carbon atoms; or ##STR17## where R 8 and R 9 are as defined above; where R 2 is methyl and R 3 is hydrogen, alkyl of from one to six carbon atoms, ##STR18## where R 10 is alkyl of from one to four carbon atoms; or where R 2 and R 3 when taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl, or hexahydro-1H-azepinyl ring.