Indane derivatives, process for their preparation, their use as medicines, pharmaceutical compositions containing them and the intermediates obtained

Abstract

Abstract New compounds of formula (I) and their salts: <IMAGE> in which R6 is H, halogen, alkyl (1-5 C), alkoxy (1-5 C), R1 and R2 are H or alkyl (1-5 C) or form a cycloalkyl (3-6 C) radical containing an O, S or N; A and B denote: - either <IMAGE> R = H or alkyl (1-5 C), Z is -CH2O- or a linear or branched alkylene (2-8 C) -(CH2)n- chain (n = 0 to 5), X, X' and X'' are H, alkyl (1-4 C), alkoxy (1-4 C), halogen, OF, CF3, NO2, NHalk1, <IMAGE> - or <IMAGE> R3 and R4 are H or alkyl (1-5 C) or form with the nitrogen to which they are bonded a 5 or 6-membered heterocyclic ring containing O, N or S; A and B cannot be chosen at the same time in one of these 2 amino groups, their preparation, their application as medications, especially central analgesics, the compositions containing them and the new intermediates obtained.

Inventors

• 👤 François Clemence
• 👤 Odile Le Martret
• 👤 Françoise Delevallee
• 👤 Michel Fortin

Bibliographic Details