7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents

Claim 1

A compound having the structure ##STR17## wherein n is an integer of from one to six; either of X or Y is oxygen and the other is --CH 2 --; R 1 is selected from ##STR18## where R 4 and R 5 are independently hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, or aryl; ##STR19## where R 6 is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms, or aryl; Z is --CH 2 --, --O--, --S--, or --NR 7 -- where R 7 is hydrogen, alkanoyl of from two to six carbon atoms, or alkyl of from one to six carbon atoms; ##STR20## where R 8 and R 9 are independently hydrogen, fluorine, chlorine, bromine , alkyl of from one to six carbon atoms, or alkoxy of from one to four carbon atoms; or ##STR21## where R 8 and R 9 are as defined above; R 2 is methyl and R 3 is hydrogen; alkyl of from one to six carbon atoms,; ##STR22## --CH 2 --CH═CH 2 , --CH 2 C.tbd.CH; ##STR23## where R 10 is alkyl of from one to four carbon atoms; or where R 2 and R 3 when taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl, or hexahydro-1H-azepinyl ring; and the pharmaceutically acceptable acid addition salts thereof.