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US5051401A
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Inhibition of mineral deposition by phosphorylated and related polyanionic peptides
Assignee: University of South Alabama
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Filing: 1989-04-07
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Granted: 1991-09-24
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Expires: 2009-04-07
Abstract
Abstract A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: poly (X)m(Y)n where each X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine, each Y independently is a phosphorylated amino acid such as phosphoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, or mixtures of these residues, m is 2 to 150, n is 1 to 3, and n+m is >/=5, and salts of these peptides.
Inventors
- 👤 C. Steven Sikes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:28
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/88; A61Q; A61Q11/00; C; C07; C07K; C07K14/00; C07K14/001; A61K38/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
62 words
A poly-amino acid compound, which has the structure: poly (X).sub.m (Y).sub.n where each X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine, or a mixture thereof, each Y independently is phosphoserine, phosphohomoserine, phosphotyrosine, phosphoglutamine, phosphoasparagine, phosphothreonine, or a mixture thereof, m is 2 to 150, n is 1 to 3, n+m is>5, and salts thereof.
Claim 2
Dependent Claim
62 words
A poly-amino acid compound, which has the structure: poly (X).sub.m (Y).sub.n where each X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine, or a mixture thereof, each Y independently is phosphoserine, phosphohomoserine, phosphotyrosine, phosphoglutamine, phosphoasparagine, phosphothreonine, or a mixture thereof, m is 2 to 150, n is 1 to 3, n+m is>5, and salts thereof.
Claim 3
Dependent Claim
31 words
A compound according to claim 1, in which the first X residue is at the C-terminal of said compound and the last Y residue is at the N-terminal of said compound.
Claim 4
Dependent Claim
31 words
A compound according to claim 1, in which the first X residue is at the N-terminal of said compound and the last Y residue is at the C-terminal of said compound.
Claim 5
Dependent Claim
41 words
A compound according to claim 1, having a formula selected from the group consisting of: H--(pSer) 1 --(Asp) 15-45 --OH, H--(pSer) 2 --(Asp) 15-40 --OH, H--(pSer) 1 --(Glu) 15-45 --OH, H--(Asp) 15-40 --(pSer) 1 --OH, and H--(Asp,Glu) 40 --(pSer) 1 --OH.
Claim 6
Dependent Claim
13 words
A compound according to claim 4, which is: H--(pSer) 1 --(Asp) 40 --OH.
Claim 7
Dependent Claim
13 words
A compound according to claim 4, which is: H--(pSer) 2 --(Asp) 40 --OH.
Claim 8
Dependent Claim
13 words
A compound according to claim 4, which is: H--(pSer) 1 --(Glu) 40 --OH.
Claim 9
Dependent Claim
10 words
A compound according to claim 1, wherein m=20--40 and n=2-3.
Claim 10
Dependent Claim
28 words
A compound according to claim 1, wherein said aspartic acid and glutamic acid residues are in the form of sodium, potassium, zinc or aluminum salts, or mixtures thereof.
Claim 11
Dependent Claim
27 words
A compound according to claim 1, wherein said phosphoserine, phosphohomoserine, phosphotyrosine, phosphoglutamine, phosphoasparagine, and phosphothreonine residues are in the form of disodium, dipotassium, calcium or magnesium salts.
Claim 12
Dependent Claim
31 words
A method of inhibiting the deposition of a mineral en a surface, which comprises contacting said surface with a mineral deposition inhibiting effective amount of a compound according to claim 1.
Claim 13
Dependent Claim
14 words
A method according to claim 11, wherein said surface is enamel of a tooth.
Claim 14
Dependent Claim
18 words
A method according to claim 11, wherein said surface is of a prosthetic device for implantation in vivo.
Claim 15
Dependent Claim
14 words
A method according to claim 13, wherein said prosthetic device is a heart valve.
Claim 16
Dependent Claim
20 words
A method according to claim 11, wherein said compound is added to a liquid in contact with an industrial container.
Claim 17
Dependent Claim
26 words
A method according to claim 11, wherein said compound is coated on or impregnated into a surface which is ordinarily in contact with a marine environment.
Claim 18
Dependent Claim
40 words
A composition for inhibiting deposition of mineral on an enamel surface of a tooth, which comprises a mineral deposition inhibitory effective amount of a compound according to claim 1, in combination with an orally acceptable vehicle compatible with said compound.
Claim 19
Dependent Claim
46 words
A composition according to claim 17, in the form of an oral hygiene formulation selected from the group consisting of mouthwashes, mouthrinses, irrigating solutions, abrasive gel dentifrices, nonabrasive gel dentifrices, denture cleansers, coated dental floss, coated interdental stimulators, chewing gums, lozenges, breath fresheners, foams and sprays.
Claim 20
Dependent Claim
33 words
An aqueous solution, comprising a crystallizable inorganic mineral, and a mineral crystallization inhibitory amount of a compound according to claim 1, wherein said inorganic mineral would crystallize in the absence of said compound.
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